Evaluation of human papillomavirus DNA detection-guided aminolaevulinic acid-mediated photodynamic therapy for the treatment of condyloma acuminata

Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients

“…The presence of the HPV DNA 6 months after four PDT sessions was found in 33.33% (7/21) of patients (five patients had the partial response and two patients had the complete response) with the presence of high-risk HPV types in 85.7% (6/7) and multiple types in 57.14% (4/7) in this group. Our results stay in concordance with the results of previous publications [5,12,[18][19][20][21]. Doorbar showed the persuasive evidence that HPV DNA can persist in the epithelium in the absence of a disease and the latent infections may persist for years or even decades [18].…”

“…Hasanzadeh et al have shown that the coexistence of high-risk and low-risk HPV types infection may be associated with both an increased risk of the development of genital warts and the risk of persistent and recurrent HPV infections [21]. Wang et al showed that the total number of ALA-PDT sessions conducted in patients infected with multiple HPV types and/or high-risk HPV types was significantly higher compared to the group infected with only one type and/or with lowrisk HPV types [12]. Those findings are confirmed by the results of our research, in which the presence of high-risk HPV types was associated with a worse clinical clearance rate and eradication rate of HPV (p = 0.05, Figure 2C) in comparison to the low-risk ones (p = 0.0003).…”

“…Those findings are confirmed by the results of our research, in which the presence of high-risk HPV types was associated with a worse clinical clearance rate and eradication rate of HPV (p = 0.05, Figure 2C) in comparison to the low-risk ones (p = 0.0003). Thus, the HPV DNA detection is the indicator of the infection severity and the prognostic factor of treatment duration [5,7,12]. Wang et al made the duration of ALA-PDT treatment dependent on obtaining HPV DNA eradication confirmed by two negative tests [12].…”

“…Thus, the HPV DNA detection is the indicator of the infection severity and the prognostic factor of treatment duration [5,7,12]. Wang et al made the duration of ALA-PDT treatment dependent on obtaining HPV DNA eradication confirmed by two negative tests [12]. Based on systematic reviews, the proper time point for the estimation of HPV DNA persistence after a follow-up of treatment is not precisely determined [22].…”

“…Therefore, the treatment of recurring HPV infections remains of key importance. Photodynamic therapy with 5-aminolaevulinic acid (ALA-PDT) as a treatment method for genital warts is becoming an increasingly common practice [10][11][12][13][14]. Studies have shown high efficacy of ALA-PDT both in the elimination of HPV infections and in the prevention of relapses.…”