Evaluation of hypoglycemic and hypolipidemic activities of aqueous extract of Cistus ladaniferus in streptozotocin-induced diabetic rats

Kabbaoui, Mohamed El; Chda, Alae; Azdad, Ouarda; Mejrhit, Najlae; Aarab, Lotfi; Bencheikh, Rachid; Tazi, A.

doi:10.1016/j.apjtb.2016.09.005

Cited by 19 publications

(11 citation statements)

References 28 publications

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“…This effect could be due to the reduction of glucose utilization by tissues and an increased hepatic glucose production, or because of decreased insulin secretion. 39 The administration of leaves exudate and isolates (Ia and Ib) of A. megalacantha showed a significant decrease in blood glucose levels following the glucose loading dose given to mice ( Figures 2 and 3 ). These results revealed that leaves exudate and TLC isolates (Ia, Ib) of A. megalacantha increased glucose utilization, which indicates the improvement of glucose homeostasis in the treated mice.…”

Section: Discussionmentioning

confidence: 94%

“…However, the observed antidiabetic activity may be due to a synergistic effect of the bioactive compounds present in the leaf exudate of A. megalacantha. 39 Five phytosterols isolated from A. Vera, namely lophenol, 24-methyl-lophenol, 24-ethyl-lophenol, cycloartanol, and 24-methylene-cycloartanol showed significant reduction of blood glucose level in diabetic mice. These phytosterols were administered for 28 days and found to be effective in decreasing blood glucose level.…”

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confidence: 98%

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Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

Araya¹,

Karim²,

Hailu³

et al. 2021

DMSO

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Background: Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by hyperglycemia which results from defects in insulin release or its efficient use by the human body. Although significant progress has been made to manage DM and related complications, it remains a major global health problem. To this end, the search for new antidiabetic drugs from traditionally claimed medicinal plants is important. Aloe megalacantha Baker is an endemic plant used traditionally to treat diabetes in Ethiopia. This study aimed to investigate antidiabetic activity of isolates from the leaf of A. megalacantha Baker in streptozotocin-induced diabetic mice. Methods: The exudate of A. megalacantha was collected by cutting the leaves and scraping the yellow sap and then dried at room temperature. The dried exudate was subjected to repeated thin layer chromatographic (TLC) separations using a mixture of solvent system to isolate the major compounds identified on the TLC plate. A single dose of streptozotocin (50 mg/kg) was injected intraperitoneally to overnight fasted mice to induce diabetes. Antidiabetic activity of TLC isolates was assessed by in vivo methods including oral glucose tolerance test, antihyperglycemic and hypoglycemic activity tests. Results: Three major isolates were obtained from the TLC analysis of the exudate of A. megalacantha. Exudate and TLC isolates were found to be non-toxic up to a dose of 2000 mg/kg. The TLC isolates (Ia and Ib) significantly (p<0.05) reduced blood glucose levels and also increased body weight change of the diabetic mice compared with control groups. Conclusion: The present study demonstrated the ability of the exudate of A. megalacantha and its TLC isolates to significantly decrease blood glucose levels and increase body weights in mice, thus strengthening the claim of its traditional use in DM-related disorders.

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 98%

Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

Araya¹,

Karim²,

Hailu³

et al. 2021

DMSO

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“…[49] Kabbaoui et al had reported that there was an increase in the levels of serum total cholesterol, triglyceride, LDL, VLDL, and decrease in the HDL levels in diabetic rats. [50] The serum total cholesterol, triglyceride, LDL, and VLDL levels were found to be significantly decreased in compared with diabetic rats. The glibenclamide-treated rats also showed a significant (P < 0.01) decrease in the abovementioned lipid levels [ Table 4].…”

Section: Lipid Profilementioning

confidence: 86%

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Ramesh¹

2018

IJGP

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Aim: The aim of the present study was to evaluate the antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of Acacia catechu (L.f) Willd leaf in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetic rats were treated with oral administration of hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) for 30 days. Various biochemical parameters such as serum glucose, protein, urea, creatinine, lipid profile, and activities of liver and kidney marker enzymes were measured to assess the antihyperglycemic and antihyperlipidemic activities of the extract. Results and Discussion: Administration of the hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) significantly decreased (P < 0.05; P < 0.01) blood glucose levels in diabetic rats and has the capacity to correct the metabolic disturbances associated with diabetes. Further, the extract decreased total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL (VLDL) levels, and increased high-density lipoprotein levels. Conclusion: The present investigation suggested that the administration of A. catechu (L.f) Willd exhibited antidiabetic activity in STZ-induced diabetic rats and could be considered for further evaluation in drug development.

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“…Diabetesinduced hyperlipidemia is attributable to excess mobilization of fat from the adipose due to the under utilization of glucose [44]. According to studies by [45,46,47] it was shown that chronic insulin deficiency as observed in alloxan-induced hyperglycaemia in experimental animals is associated with diminished levels of LDL receptors, blood cholesterol and triglyceride [48,49]. This results to an increase in LDL particles and consequently increases serum level of LDL.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats

Mashi¹

2018

IJBBMB

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Diabetes is a heterogeneous disorder with multiple etiologies resulting in major healthcare problem such as risk of heart disease, stroke and micro-vascular complications such as blindness, renal failure and peripheral neuropathy. The research was aimed at evaluating the antihyperglycaemic and antihyperlipidemic potentials of ethyl acetate fraction of Persea americana leaf in alloxan-induced diabetic rats. Persea americana leaf was extracted by soxhlet extraction for 24hrs and concentrated in vacuo to yield Persea americana extract (PAE). Elemental compositional analysis of the extract was determine using flame atomic absorption spectroscopy. Hyperglycemia was induced by intraperitoneal administration of alloxan. Blood glucose levels determined using ACCUCHEK. Hypoglycemic activity was evaluated by measuring serum glucose level and insulin level. Hypolipidemic activity was evaluated by measuring various biochemical parameters like total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and high density lipoprotein. Elemental compositional analysis of the Fraction reveals the presence of Zn, Cr, Mg, Fe, Cu and Mn. The levels of fasting blood glucose were found to decrease significantly in the treated groups in a dose dependent pattern with reversal in body weight lost as well as significant increase in serum insulin level compared with the diabetic control group. The results showed that serum total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein levels were statistically lower in the treated groups. The observed hypoglycaemic alongside with hypolipidemic effect can be associated with the levels of trace elements present in the extract. The present study support the traditional claim in the use of ethyl acetate extract of P. americana leaf as hypoglycaemic and hypolipidemic agent.

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Evaluation of hypoglycemic and hypolipidemic activities of aqueous extract of Cistus ladaniferus in streptozotocin-induced diabetic rats

Cited by 19 publications

References 28 publications

Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

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Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats

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Evaluation of hypoglycemic and hypolipidemic activities of aqueous extract of Cistus ladaniferus in streptozotocin-induced diabetic rats

Cited by 19 publications

References 28 publications

Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

Antihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice

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Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of &lt;i&gt;P. americana&lt;/i&gt; Leaf in Alloxan-Induced Diabetic Rats

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Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats