Evaluation of Hypolipidemic Effect of Various Extracts of Whole Plant of Bauhinia purpurea in Rat Fed with High Fat Diet

Shajiselvin, C. D.; Muthu, A. Kottai

doi:10.1007/978-81-322-1035-1_36

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…Regarding to serum LDL-C, VLDL-C, HDL-C and phospholipids in hyperlipidemia, rats gave a significant increase in LDL-C, VLDL-C and phospholipids with a significant decrease in HDL were obtained when compared to control group. These results agree with that of Lamiaa and Barakat (2011) and Shajiselvin and Muthu (2013). High-fat diet changes the lipoprotein profile to a more atherogenic one by increasing levels of LDL-C and lowering HDL-C (Srivastava et al, 2000).…”

Section: Discusionsupporting

confidence: 92%

“…In this study; the result of serum lipids profile; hyperlipidemia group showed significant increase in total cholesterol, triacylglycerol and total lipids concentrations when compared to control group. These results agree with Lamiaa and Barakat (2011), Sivakumar and Sivakumar (2004) and Shajiselvin and Muthu (2013). Diets supplemented with varying amounts of cholesterol can induce hypercholesterolemia in mice and rats by interfering with the hepatobiliary excretion of cholesterol (Kamesh and Sumathi., 2012).…”

Section: Discusionsupporting

confidence: 89%

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Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Elsenousy

Farid

Fararh

2019

Benha Veterinary Medical Journal

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The present study was designed to investigate the hypolipidemic effect of pumpkin seed oil in experimental hyperlipidemic rats. Fifty male rats were divided into five equal groups. Group 1: normal rats fed on normal diet. Group 2: (hyperlipidemic group) rats administered standard diet+ 20%coconut oil and 1% cholesterol daily for eight weeks. Group 3: (hyperlipidemic +pumpkin seed oil treated group) rats administered standard diet+ 20%coconut oil and 1% cholesterol daily for four weeks followed by atherogenic diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for other four weeks. Group 4: (hyperlipidemic +pumpkin seed oil protected group) rats administered standard diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for two weeks followed by standard diet+ 20%coconut oil and 1% cholesterol+ 50 mg/Kg b. wt. pumpkin seed oil daily for eight weeks. Group 5 : (pumpkin seed oil group) rats administered standard diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for eight weeks. Blood samples collected for serum separation and used for determination of lipids profile (total cholesterol, triacylglycerol, LDL-C, HDL-C, VLDL-C, total lipids and phospholipids), liver marker enzymes (ALT and AST), albumin, kidney function markers (urea and creatinine) and glucose concentration. The results revealed that in group 2 there were significant increases in serum total cholesterol, triglycerides, LDL-C, VLDL-C, phospholipids, total lipids, ALT, AST, urea, creatinine and glucose while HDL-C and albumin were significantly decreased. Meanwhile, administration of pumpkin seed oil resulted in significant decrease in all elevated mentioned parameters and increase in HDL-C and albumin levels. Therefore, it could be concluded that pumpkin seed oil has hypolipidemic and hypoglycemic effect in rats fed high fat diet.

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Section: Discusionsupporting

confidence: 92%

Section: Discusionsupporting

confidence: 89%

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Elsenousy

Farid

Fararh

2019

Benha Veterinary Medical Journal

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“…No researches were found dealing with in vivo antioxidant activity of Bauhinia variegata extracts in diabetic rats . So, the present results were supported by Shajiselvin and Muthu (2011)who dealt with Bauhinia purpurea ethyl acetate extract. They showed that administration of this extract to rats fed high fat diet significantly increased the levels of antioxidant enzymes , such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione reductase (GR) and the level of non enzymatic antioxidant Glutathione (GSH) , when compared with high fat diet rats .…”

Section: Antioxidant Defence System Activitysupporting

confidence: 82%

EVALUATION OF ANTIDIABETIC,ANTIHYPERLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF THE METHANOLIC EXTRACT OF Bauhinia variegata AND Enterolobium cyclocarpum LEAVES IN STREPTOZOTOCIN DIABETIC RATS

Sanad

El-Rafey,

Hassan

et al. 2012

Journal of Agricultural Chemistry and Biotechnology

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Hypoglycemic action of methanolic extracts of Bauhinia variegata and Enterolobium cyclocarpum leaves were studied on streptozotocin diabetic rats. Two different doses(200 and 400 mg/kg body weight)of the extracts were given orally to the rats for 22 days. Lipid profile improvement and hepatoprotective effects against liver disorders associated with diabetic complications were also studied .Results revealed that Bauhinia variegata extract showed a strong antidiabetic activity at the two doses. The doses of 400mg/kg b.wt. showed the highest activity. Enterolobium cyclocarpum extract at the two doses failed to decrease blood glucose level to the healthy range. The mode of Hypoglycemic action of Bauhinia variegata extract may due to the presence of considerable amounts of Flavonoids and polyphenols. The two extracts (Bauhinia variegata and Enterolobium cyclocarpum) could improve lipid profile of diabetic rats and Enterolobium cyclocarpum had weaker ability. Bauhinia variegata methanolic extract resulted in significant decrease in liver malondialdehyde (MDA)and increase in reduced glutathione (GSH) .

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“…and Physalis minima L. has been shown to suppress lipid peroxidation in goat liver homogenate reported by Dinakaran et al, 22 . The methanol extract of Borreria hispida have significant in vivo antioxidant and lipid peroxidation activity when compared with petroleum ether and ethyl acetate extracts were demonstrated by Shajiselvin et al, 23 . In the present study too, the extracts of Cucumis melo fruits inhibited lipid peroxidation.…”

Section: Discussionmentioning

confidence: 94%

Untitled

2014

IJPSR

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Plant derived natural products such as flavonoids, terpenes, alkaloids and polysaccharides have received considerable attention in recent years due to diverse pharmacological properties including cytotoxic and cancer chemo preventive effects. From a long period of time medicinal plants or their secondary metabolites have been directly or indirectly playing an important role in the human society to combat diseases. Oxidative stress results from an excessive production of reactive oxygen species beyond the body's antioxidant capacity. The over production of reactive oxygen species can lead to damage to cellular biomolecules, which is implicated in the development of many diseases including cell death. The reactive oxygen species can be eliminated /deactivated by a number of antioxidants which include enzymic and non-enzymic antioxidants. The plant selected for the present study is Cucumis melo (Family: Cucurbitaceae) commonly known as Musk melon. Cucumis melo helps in increasing appetite, weight loss, urinary tract infections, constipation, acidity and ulcers. The goat liver was selected as the mammalian tissue to determine the antioxidant effect of ethanol extract in the presence and absence of the standard oxidizing compound (H 2 O 2). This work suggested the antioxidant effects of Cucumis melo fruit extract on oxidatively stressed precision-cut liver slices is potentially exhibited.

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Evaluation of Hypolipidemic Effect of Various Extracts of Whole Plant of Bauhinia purpurea in Rat Fed with High Fat Diet

Cited by 4 publications

References 18 publications

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

EVALUATION OF ANTIDIABETIC,ANTIHYPERLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF THE METHANOLIC EXTRACT OF Bauhinia variegata AND Enterolobium cyclocarpum LEAVES IN STREPTOZOTOCIN DIABETIC RATS

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