Evaluation of <i>Candida</i> scoring systems to predict early candidemia: A prospective and observational study at a tertiary care hospital, Uttarakhand

Gupta, Priyanka; Gupta, Pratima; Chatterjee, Biswaroop; Mittal, Garima; Prateek, Shashank; Mohanty, Aroop

doi:10.4103/ijccm.ijccm_159_17

Cited by 6 publications

(11 citation statements)

References 17 publications

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“…In the present study the higher prevalence of Candida species was seen in males, which coincides well with the Gupta et al 5 where as much higher prevalence shown by Xess et al 6 and lower prevalence shown by Singh and Abraham. 7 It is concluded that males are more prone to Candida infection because of poor hygiene, diabetes and prolonged use of antibiotics and the yeast like fungus form normal commensal of oral, mucosal, gastrointestinal and genitourinary tract of human.…”

Section: Discussionsupporting

confidence: 92%

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Speciation and antifungal susceptibility pattern of Candida isolated from blood and body fluids

Kaur¹,

Aijaz

2023

IJMR

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infections are increasing now a day due to various factors. The present study was carried out to study the speciation and antifungal susceptibility pattern of isolated from blood and body fluids. Blood and body fluids received in the mycology laboratory of Microbiology Department, AIMSR, over a period of six months were included. After microscopy, culture was done. The spp. were diagnosed on the basis of colony characteristics, Gram staining and Germ tube testing and identification by Automated Vitek 2 system. Antifungal susceptibility testing was done by using YST08 cards. A total of 735 samples received, 53 showed Candida spp. Maximum spp. isolated from blood 23 (43.39%), followed by pleural fluid 14 (26.4%). were 24(45.3%) followed by 11(20.75%), 9(16.98%) 7(13.20%). spp. were sensitive to Amphotericin B and resistant to Fluconazole.

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Section: Discussionsupporting

confidence: 92%

“…Dharvad and Dominic (2011) showed higher prevalence by C. albicans (47%) followed by C. tropicalis (30%), C.krusei (14%) and C. glabrata (9%). 8,13 Deorukhkar and Saini (2012) and Gupta et al (2015) showed higher prevalence by C. albicans. 5 Chander et al (2013) and Kaur et al (2014) showed higher prevalence by C. tropicalis.…”

Section: Discussionmentioning

confidence: 92%

Speciation and antifungal susceptibility pattern of Candida isolated from blood and body fluids

Kaur¹,

Aijaz

2023

IJMR

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“…In that study, it was concluded that Leone score of ≥2.5 is most suitable for ruling in the diagnosis of invasive candidiasis. 12 However, Leon et al and Blumberg et al reported Total Parenteral Nutrition (TPN) as a clinically significant risk factor; similarly, we observed only 03 patients on TPN and out of them 02 were having candidemia. But the relation cannot be established due to lower usage of TPN in our ICU during the study period.…”

Section: Discussionsupporting

confidence: 60%

Evaluation of Candida Score: a bedside scoring system for early antifungal therapy in non-neutropenic critically ill patients

Dash¹,

Pal²,

Sinha³

2019

Int J Adv Med

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Background: Invasive Candida infections are the most common invasive fungal infections. Multiple site colonization plays a major role. Further decrease in host immunity (e.g. neutropenia, diabetes mellitus etc.) aggravates local invasion and dissemination which finally leads to candidemia. Hence the study was done to evaluate “Candida Score” in non-neutropenic critically ill patients for early antifungal therapy.Methods: In this prospective observational cohort study, all critically ill patients having sepsis or septic shock on admission or during their stay in ICU stay were included in the study. The components of “Candida Score” like severe sepsis, total parenteral nutrition, surgery, and multifocal Candida colonization were as per Leone et al. Clinical sepsis was given score of 2 if present and 0 if absent. The other variables were given score 01 if present and 0 if absent. The score more than 2.5 is considered significant.Results: Out of 78 patients admitted in the ICU a total of 26 blood culture positives were reported. The prevalence of Candidemia (based on culture) was 23.1% (n=06). The strains isolated were Candida non albicans (n=4, 66.7%) and Canida albicans (n=2, 33.3%). Candida was isolated in different samples other than blood culture of 26(33.33%). The most common specimen with Candida isolation was from urine (n=14, 60.87%), followed by endotracheal aspiration and sputum (n=3, 13% each) and BAL fluid (n=1, 04.3%). Among the isolates Candida non albicans (n=12, 52.2%) was more prevalent than Candida albicans (n=11, 47.8%). The prevalence was maximum for the age group of 60 to 69 years (42.31%) followed by 70 to 79 yrs and 50-59 yrs. Among all patients, 14 patients were referred in our hospital and 12 of them had a prolonged ICU stay (>10 Days). The patients with the Candida score ≥2.5 were 06 in numbers, of which 66.7% were having score 3 followed by one each of having score 4 and 5. Out of these 06 patients 04 received antifungal treatment. One patient with Candida score more than 03 succumbed to death without having antifungal treatment.Conclusions: Early identification of invasive candidiasis with the use of “Candida Score” in critically ill patients may help to initiate antifungal interventions and even help the treating physician or intensivist to formulate the more effective treatment algorithms.

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“…C. albicans and C. parapsilosis were the most prevalent species isolated from blood samples. C. albicans has been repeatedly identified in studies as the most common yeast species [ 7 , 9 , 21 , 22 ]. C. parapsilosis was the second Candida species in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Although in this study, 77.3% of patients had received at least one antifungal drug, the mortality rate was high (63.6%). However, higher mortality rates have also been reported [ 21 ]. Our findings suggest that patients with C. albicans candidemia have the lowest mortality rate (41.7%).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia in intensive care units in Isfahan, Iran

Haghighatfard¹,

Abbasi²,

Alijani³

et al. 2022

CMM

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Background and Purpose: Candidemia is known as an invasive fungal infection with high mortality. The prevalence of candidemia in intensive care unit (ICU) patients is more than in other hospital wards. Early diagnosis of candidemia in these patients is essential for disease management. Materials and Methods: This study included 250 patients suspected of candidemia. Blood samples were taken from patients and incubated. The fungal isolates were identified by PCR-RFLP method using MSP I restriction enzyme. Demographic characteristics, risk factors, underlying diseases, and laboratory analysis results were mined in this study. Results: In total, 22 blood samples were identified as positive for Candida yeasts in culture. The most common underlying diseases in these patients were heart disease and hypertension (36.4%). Candida albicans with 12 cases (54.5%) was the most isolated species, followed by C. parapsilosis (n=5, 22.7%), C. glabrata (n=4, 18.2%), and C. tropicalis (n=1, 4.5%) in descending order. Intravenous catheter use was recognized as the most common risk factor in patients with candidemia (77.3%), and after that, the use of mechanical ventilation (68.2%) and urinary catheter (40.9%) obtained the highest frequency. Furthermore, 17 patients were prescribed at least one antifungal drug, of which fluconazole was the most used (36.4%). The mortality rate in patients in this study was 63.6%. All C. albicans isolates were susceptible to antifungal agents but in non-albicans Candida (NAC), drug resistance to fluconazole, voriconazole, and caspofungin were observed. Conclusion: Although C. albicans was the most common fungal species in this study, the prevalence of NAC species was high. The increasing frequency of NAC species is a concern because they have different patterns of drug resistance. Recognition of risk factors in patients admitted to ICUs can help prevent candidemia or properly manage the disease.

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Evaluation of Candida scoring systems to predict early candidemia: A prospective and observational study at a tertiary care hospital, Uttarakhand

Cited by 6 publications

References 17 publications

Speciation and antifungal susceptibility pattern of Candida isolated from blood and body fluids

Speciation and antifungal susceptibility pattern of Candida isolated from blood and body fluids

Evaluation of Candida Score: a bedside scoring system for early antifungal therapy in non-neutropenic critically ill patients

Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia in intensive care units in Isfahan, Iran

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