Evaluation of <i>E2F3</i> and <i>survivin</i> expression in peripheral blood as potential diagnostic markers of prostate cancer

Wadaa-Allah, Ahmed; Hamid, Fatma F. Abdel; Soliman, A.A.; Ibrahim, Noha; Malash, Ibrahim; Abdelgawad, Iman

doi:10.1515/tjb-2019-0323

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…We performed the Shapiro-Wilk test to determine the type of data distribution. 16,17 Parametric data were stated as mean ± SD. The Student's t-test was performed for parametric data to compare quantitative variables between two groups.…”

Section: Methodsmentioning

confidence: 99%

The association of angiotensin-converting enzyme gene polymorphism with respiratory distress syndrome in premature neonates

Midan¹,

El-Ella²,

Tawfik³

et al. 2022

Turk J Pediatr

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Background. There was a contradiction in the previous literature on whether the D/D genotype of angiotensinconverting enzyme (ACE) is a protective or risk factor for respiratory distress syndrome (RDS) in premature neonates. To solve this debate, we intended to examine the association between ACE gene polymorphism and RDS in premature neonates. Methods. We enrolled a total of 100 premature neonates with gestational age below 37 weeks. They were divided into 2 groups, the case group included 50 premature neonates diagnosed with RDS. While the control group included 50 premature neonates with no signs of RDS. We assessed ACE gene polymorphism using polymerase chain reaction. All neonates underwent chest x-ray, echocardiography, and routine laboratory investigations. Results. D/D and D/I genotypes were higher in the control group (48% and 50%) than in the case group (26% and 40%). Whereas, I/I genotype was lower in the control group (2%) than in the case group (34%) (p < 0.001). By counting D alleles among members of both groups, D-alleles were significantly higher in the control group (73%) than in the case group (46%) (p < 0.001). Conclusions. In premature neonates, D/D and D/I genotypes and D-alleles are protective factors for RDS. Whereas, I/I genotype and I-alleles are associated with the incidence of RDS with complications.

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Section: Methodsmentioning

confidence: 99%

The association of angiotensin-converting enzyme gene polymorphism with respiratory distress syndrome in premature neonates

Midan¹,

El-Ella²,

Tawfik³

et al. 2022

Turk J Pediatr

View full text Add to dashboard Cite

show abstract

“…Spearman’s correlation was used to show the correlation between two continuous non-parametric data. Receiver operating characteristics (ROC) analysis was performed to assess biomarker performance, 18 with respective maximum accuracy points for both sensitivity and specificity. Positive predictive value (PPV) and negative predictive value (NPV) were also calculated.…”

Section: Methodsmentioning

confidence: 99%

Cord blood microRNA-376c and microRNA-1268a as biomarkers for neonatal hypoxic-ischaemic encephalopathy: a diagnostic accuracy study

Midan

Bahbah

Fayed

et al. 2021

bmjpo

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BackgroundHypoxic-ischaemic encephalopathy (HIE) is one of the most common causes of morbidity and mortality among neonates. There is a critical need for non-invasive novel biomarkers to detect HIE early, predict its outcomes and monitor its progression. We conducted this observational study to assess the relative expression of miRNA-376c and miRNA-1268a in cord blood as potential diagnostic and prognostic biomarkers for HIE.MethodsA total of 100 neonates divided into two independent groups were included. The case group included 50 neonates with HIE, while the control group included 50 matched healthy neonates. Relative expressions of miRNA-376c and miRNA-1268a were measured in whole cord blood at birth using real-time PCR.ResultsCompared with the control group, patients with HIE had a significantly lower median level of miRNA-376c (0.168, IQR=0.011–0.411 vs 1, IQR=0.80–1.20) and a higher median level of miRNA-1268a (13.46, IQR=2.7–22.8 vs 1, IQR=0.4–1.6). Comparing neonates with HIE who survived versus those who did not survive, no statistically significant difference between the groups in terms of miRNA-376c and miRNA-1268a (p=0.124 and p=0.279) was elicited. Our diagnostic analysis showed that, at 0.90 points, miRNA-376c has a sensitivity and a specificity of 88% and 68.40%, with an area under the curve of 84%. At 2.70 points, miRNA-1268a has a sensitivity and a specificity of 76% and 100%, with an area under the curve of 96%.ConclusionThe relative expression of miRNA-376c and miRNA-1268a was altered in the cord blood of neonates with HIE. In addition, they have moderate diagnostic accuracy in detecting HIE.

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Evaluation of E2F3 and survivin expression in peripheral blood as potential diagnostic markers of prostate cancer

Cited by 2 publications

References 43 publications

The association of angiotensin-converting enzyme gene polymorphism with respiratory distress syndrome in premature neonates

The association of angiotensin-converting enzyme gene polymorphism with respiratory distress syndrome in premature neonates

Cord blood microRNA-376c and microRNA-1268a as biomarkers for neonatal hypoxic-ischaemic encephalopathy: a diagnostic accuracy study

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