2017
DOI: 10.1080/14786419.2017.1356829
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Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation

Abstract: The present study was undertaken to evaluate the in vivo analgesic activities of the extracts prepared from the aerial parts and roots of Scrophularia kotscyhana and to isolate the bioactive metabolites from the most active extract. Analgesic activities of all extracts and subextracts at the doses of 5, 10 and 30 mg/kg (i.p.) were examined using hot plate test in mice. Among the tested extracts, MeOH extract prepared from the aerial parts and the n-butanol subextract prepared thereof displayed the best analges… Show more

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Cited by 3 publications
(5 citation statements)
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“…Like our previous study on the analgesic activities of the crude extracts of the same species, we evaluated the anti-inflammatory activities of the n -hexane, dichloromethane, ethyl acetate, n -butanol and water subextracts derived from the MeOH extract of aerial parts at the dose of 30 mg/kg. 10 As shown in Figure 2, all of the subextracts obtained from the aerial parts exhibited significant ( p < .05) pain inhibition at the dose of 30 mg/kg when compared with saline. In hind paw thicknesses, volume and pain inhibition tests, all the subextracts tend to have positive effects (Tables 1 and 2; Figure 2), but as we compared the results of all tests, we decided to study the effect of lower doses (5 mg/kg and 10 mg/kg) of n -butanol and water subextracts.…”
Section: Resultsmentioning
confidence: 85%
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“…Like our previous study on the analgesic activities of the crude extracts of the same species, we evaluated the anti-inflammatory activities of the n -hexane, dichloromethane, ethyl acetate, n -butanol and water subextracts derived from the MeOH extract of aerial parts at the dose of 30 mg/kg. 10 As shown in Figure 2, all of the subextracts obtained from the aerial parts exhibited significant ( p < .05) pain inhibition at the dose of 30 mg/kg when compared with saline. In hind paw thicknesses, volume and pain inhibition tests, all the subextracts tend to have positive effects (Tables 1 and 2; Figure 2), but as we compared the results of all tests, we decided to study the effect of lower doses (5 mg/kg and 10 mg/kg) of n -butanol and water subextracts.…”
Section: Resultsmentioning
confidence: 85%
“…n -butanol and water subextracts generated a significant reduction at both phases of the formalin test, by suggesting that n -butanol extract has an analgesic effect with inhibitory mechanisms on neurogenic nociception and inflammatory nociception. 10 These results require further study to investigate the possible mechanism of action that may be involved.…”
Section: Discussionmentioning
confidence: 99%
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“…Iridoid glycosides from S. umbrosa were reported to have inhibitory activity on nitric oxide production [15]. Two iridoid glycosides with analgesic activity were reported from S. kotscyhana [16].…”
Section: Introductionmentioning
confidence: 99%