Evaluation of<i>Paracoccidioides brasiliensis</i>exoantigen in the detection of delayed dermal hypersensitivity in experimental and human paracoccidioidomycosis

Marques, Mariângela Esther Alencar; Soares, Ângela Maria Victoriano de Campos; Franco, Marcello; Camargo, Zoilo Pires de; Marques, Sílvio Alencar; Mendes, Rinaldo Pôncio; Souza, Lenice do Rosário de; Coelho, Kunie Iabuki Rabello

doi:10.1080/02681219680000451

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Results of a histological evaluation of positive skin tests performed in human volunteers showed that the cell population responsible for a DTH response was similar to Fava Netto paracoccidioidin and gp43. However, the intensity of the DTH in patients with PCM tested with both antigens was higher among those tested with the glycoprotein [4,8].…”

Section: Introductionmentioning

confidence: 79%

“…Paracoccidioidal infection is an asymptomatic infection caused by thermo-dimorphic fungi of Paracoccidioides genus in individuals that reside or have resided in an endemic area, and it reacts to paracoccidioidin in delayed-type hypersensitivity (DTH) tests [1]. These tests may also be used to evaluate cellular immunity in patients with paracoccidioidomycosis (PCM), thus allowing physicians to assess the severity and prognosis, as well as the recovery from a specific immune response after antifungal treatment [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

et al. 2017

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

et al. 2017

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“…Studies on intradermal reaction using antigens obtained from strains of the Paracoccidioides genus have been carried out to identify endemic areas of PCM [ 66 , 67 , 68 , 69 ]. However, the choice of the antigen and its preparation play a crucial role because there are different biochemical compositions, and they will be injected in the population and cross-reactions with similar fungi, such as Histoplasma capsulatum var.…”

Section: Discussionmentioning

confidence: 99%

“…However, the choice of the antigen and its preparation play a crucial role because there are different biochemical compositions, and they will be injected in the population and cross-reactions with similar fungi, such as Histoplasma capsulatum var. capsulatum , can occur [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Geoclimatic Factors on the Distribution of Paracoccidioidomycosis in Mato Grosso do Sul, Brazil

Fabris,

de Oliveira,

Bortolomai

et al. 2024

JoF

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The incidence of paracoccidioidomycosis (PCM) varies in Latin America, and it is influenced by environmental factors. This study evaluated the distribution of PCM acute/subacute form (AF) cases and their correlation with geoclimatic factors in the Mato Grosso do Sul (MS) state. The study included 81 patients diagnosed with the PCM/AF at the University Hospital of the Federal University of Mato Grosso do Sul between January 1980 and February 2022. Geographic coordinates, health microregion of patient’s residence, compensated average temperature, relative air humidity (RH), El Niño Southern Oscillation (ENSO), and average global temperature were analyzed. The highest incidence was observed in the Aquidauana (7/100,000 inhabitants), while Campo Grande, the state’s capital, had the highest number (n = 34; 42.4%) and density (4.4 cases/km2) of cases. The number of cases increased during extended periods of the El Niño phenomenon. A positive correlation was found between higher RH and PCM/AF cases. Most PCM/AF cases were found in areas with loamy soils and RH ranging from 60.8 to 73.6%. In MS, the health microregions of PCM/AF patients are characterized by deforestation for agricultural and pasture use, coupled with loamy soils and specific climatic phenomena leading to higher soil humidity.

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In vitro human immune reactivity of fast protein liquid chromatography fractionated soluble antigens

Diniz

Cisalpino

Koury

et al. 1999

Microbes and Infection

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Evaluation ofParacoccidioides brasiliensisexoantigen in the detection of delayed dermal hypersensitivity in experimental and human paracoccidioidomycosis

Cited by 4 publications

References 15 publications

Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

The Effect of Geoclimatic Factors on the Distribution of Paracoccidioidomycosis in Mato Grosso do Sul, Brazil

In vitro human immune reactivity of fast protein liquid chromatography fractionated soluble antigens

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