Evaluation of IgG4 Levels as a Fibrosis Marker On Disease Activity in the Course of Hepatitis B Infection

Abstract

Aim: Understanding immunopathogenesis of hepatitis-B virus (HBV) infection is pivotal in the management of complications. The aim of the study is to investigate the association of IgG4 levels with the liver fibrosis. Methods: Histological evaluation of the liver biopsy and laboratory analyses including IgG4 were performed. Results: A total of 130 patients fulfilling the criteria for a diagnosis of HBV infection were enrolled in the study. Of these patients, 14 had HBeAg positive and 116 had HBeAg negative HBV infection. In HBeAg-positive patients serum IgG4 levels were significantly higher than HBeAg-negative patients (p = 0.038). Conclusion: There is an association of IgG4 level and higher rates of viral replication and enhanced infectivity.