Evaluation of Immune Response to Hepatitis B Vaccine in Healthcare Workers at a Tertiary Care Hospital

Basireddy, Praveena; Surekha, A.; Beldono, Nagajyothi; Gundela, Swarna Latha

doi:10.4103/ijmm.ijmm_17_431

Cited by 18 publications

(12 citation statements)

References 20 publications

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“…Higher vaccinal coverage rate was reported in Iran (87.90% and 85.40%, respectively) [26,27]. Our results are not in line with studies of Chathuranga et al (65%) in Sri Lanka [28] and Basireddy et al (32.90%) in India [29], conducted among HCWs.…”

Section: Resultscontrasting

confidence: 90%

Hepatitis B vaccination coverage rate and immune response among primary health care workers in Sarajevo Canton, Bosnia and Herzegovina

Šegalo

Kiseljaković

Berhamović

et al. 2020

Microbes and Infectious Diseases

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Background: Immunization is a key step in preventing the occupational risk of acquiring hepatitis B infection for healthcare workers (HCWs). The aim of the study was determination of hepatitis B vaccine (HepB) coverage rate among HCWs and support staff and immune response 10 years after primary vaccination. Methods: A retrospective study was conducted in the Public Institution Health Centre of Sarajevo Canton in Bosnia and Herzegovina during 2005-2017. Second-generation vaccines Euvax (Sanofi Pasteur, Thailand/LG Life Sciences Ltd, Korea) and Engerix B (GlaxoSmithKline, Belgium) were applied. For quantification of antibody response to hepatitis B virus surface antigen three laboratory methods were used. A level of ≥ 10 IU/L anti-HBs was set as a cut-off value indicating the presence of protective immunity against new HBV infections and successful vaccination. Results: In total, 1541 (75.80%) were fully vaccinated, out of 1126 (73.07%) were females. The median age of participans was 50.5 ± 9.4 years. Control measurement of the anti-HBs level was performed for 409 (26.54%) HCWs, and the presence of protective antibodies was confirmed in 304 (74.33%). During the research, 37 booster doses were administered. Of the 23 retested participants, anti-HBs ≥10 IU/L were observed in 19 (82.16%). Three non-reactors subject were revealed. Conclusion: A satisfying HepB coverage rate and a high protective rate against hepatitis B infection among HCWs and support staff was achived, although vaccination is voluntary in Bosnia and Herzegovina. These results indicate the active engagement of the institution in the implementation of preventive measures and the high level of awareness regarding the significance of immunization. Our results demonstrated the effectiveness of booster doses. A low prevalence of non-reactors was revealed. Additional research with a focus on occupational risk factors in dental service is advised.

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Section: Resultscontrasting

confidence: 90%

Hepatitis B vaccination coverage rate and immune response among primary health care workers in Sarajevo Canton, Bosnia and Herzegovina

Šegalo

Kiseljaković

Berhamović

et al. 2020

Microbes and Infectious Diseases

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“…Similar observation has been reported. 2 It maybe because advancing age proves to be a big factor for low antibody response and could be due to a decrease in lymphocyte proliferation activity. The other factors identified for non-response was male gender (56%) as compared to the females (44%) which is coherent to a previous study.…”

Section: Discussionmentioning

confidence: 99%

“…1 It is the most important occupational health hazard among the Health Care Workers (HCWs). 2 Due to frequent handling of blood and body fluids of patients,HCWs are four times more at risk of contracting HBV infection as compared to the general population. 3 Immunization with Hepatitis B vaccine remains the most effective way of prevention of HBV infection (HBVI).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Vaccinationstatus and Status of Vaccine Non- Responders among Healthcare Workers in a Tertiary Care Hospital of Western Uttar Pradesh

Mehak Manro,

Anita Pandey,

Priyanka Chaturvedi

et al. 2021

IJPHRD

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Background and Aims: Health care workers (HCWs) are at risk of acquiring Hepatitis B Virus infection (HBVI). Despite being a vaccine preventable disease, the vaccine "non-responders" are at a constant risk of acquiring infectiondue to lack of seroconversion. The current study aims to evaluate theHepatitis B vaccination coverage and status of vaccine non-responders among HCWs in a tertiary care hospital.Methods: Among the 183 participating HCWs, 11(6.01%) who were Hepatitis B surface antigen (HBsAg) positive were excluded from the study. Estimation of anti-HBs titre was determined in HBsAg negative individuals. The HCWs with antibody titre <10mIU/ml (non-response) were identified and revaccinated. Post-vaccination titre in these individuals was reassessed 1-2 months after the last dose of both the vaccination series to look for sero-conversion and finally identify the vaccine non-responders.Individuals who did not seroconvert even after the 2 nd series of vaccination were thus labelled as "non-responders".Result: Overall, 72.67 % HCWs were immune (anti HBs titre ≥10mIU/ml). Male population, age ≥50 years, smokers, history of hospitalisation, previous operations and dental procedures in the past were the predisposing factors identified in non-response HCWs. Sero-conversion was seen in 96% of non-responsive HCWs. A total of 4% HCWs were vaccine "non-responders". Conclusion:Complete vaccination coverage was low among health care workers. The vaccine nonresponders were identified,counselled and posted at low risk area for their safety. Every health care organizationshould have a mandatory policy to vaccinateall the HCWsirrespective of their vaccination status at the commencement of their joband monitor their post vaccination antibody titre.

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“…In similarity to our result study by Basireddy P et al, Farahnaz et al and Sahana et al showed decrease in antibody titers with increasing age. [12][13][14]…”

Section: Discussionmentioning

confidence: 99%

Study to Assess the Status of Hepatitis B Vaccination and Factors Affecting Antibody Titers Level for Hepatitis B to Various Health Care Workers and Medical Students in Tertiary Healthcare Setup in Himachal Pradesh

2021

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Background: Hepatitis B(HBV) is one of the most important occupational hazards among the medical student and healthcare workers(HCW's) due to risk of exposure to infected bodily fluids and blood. This study aimed to assess status of HBV vaccination and factors affecting anti-HBs titres levels for HBV in HCW and medical students. Material and Method: It was a prospective, descriptive and cross sectional study done at the Department of Microbiology, DRPGMC Kangra at Tanda(H.P). Randomly 215 HCW’s and medical students were taken in the study who fulfilled the inclusion criteria. Results: Total of 215 subjects were included in the study. Males were 89 and females were 126. 182 subjects were vaccinated and 33 were unvaccinated for hepatitis B. Out of 182 vaccinated 137 were completely vaccinated. Significant correlation was seen with decrease in antibody titers with gender, duration of vaccination and smoking. Conclusion: Vaccination should be mandatory for every HCW and medical student entering the health institutions. The factors affecting the antibody titers must be evaluated and antibody titers must be reviewed from time to time. The need for a booster dose can be made mandatory at least for healthcare professionals. Keywords: Hepatitis B virus, Vaccination, Antibody titers, HCW.

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Evaluation of Immune Response to Hepatitis B Vaccine in Healthcare Workers at a Tertiary Care Hospital

Cited by 18 publications

References 20 publications

Hepatitis B vaccination coverage rate and immune response among primary health care workers in Sarajevo Canton, Bosnia and Herzegovina

Hepatitis B vaccination coverage rate and immune response among primary health care workers in Sarajevo Canton, Bosnia and Herzegovina

Hepatitis B Vaccinationstatus and Status of Vaccine Non- Responders among Healthcare Workers in a Tertiary Care Hospital of Western Uttar Pradesh

Study to Assess the Status of Hepatitis B Vaccination and Factors Affecting Antibody Titers Level for Hepatitis B to Various Health Care Workers and Medical Students in Tertiary Healthcare Setup in Himachal Pradesh

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