2018
DOI: 10.26438/ijsrbs/v5i3.15
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Evaluation of immunomodulatory effect of Tinospora cordifolia leaf and stem on zidovudine induced immunotoxicity

Abstract: The present study was conducted to evaluate immunomodulatory effect of Tinospora cordifolia (T.C) leaf and stem extracts on zidovudine induced immunotoxicity. T.C leaves and stem was collected and three different extracts of stem and leaf (Aqueous, methanol, n-hexane) was prepared by Soxhlet extraction. Total 24 rats were used in the study. Rats were divided into 4 groups each of 6 rats. Group-I was treated with distilled water. Group-II rats received Zidovudine (500 mg/kg), Group-III given alcoholic extract o… Show more

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“…Similar results were observed in rats treated with calcium chloride, where administration of T. cordifolia extracts inhibited the immunosuppressive effect of calcium chloride (Bishayi et al, 2002). Stem and leaf extracts of the plant also ameliorated the immuno-suppressive effects of azidothymidine (a common drug used in treatment of AIDS) in pre-clinical trials (Nageswari, Reddy & Venkatappa, 2018).…”
Section: Immuno-modulatory Activitysupporting
confidence: 66%
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“…Similar results were observed in rats treated with calcium chloride, where administration of T. cordifolia extracts inhibited the immunosuppressive effect of calcium chloride (Bishayi et al, 2002). Stem and leaf extracts of the plant also ameliorated the immuno-suppressive effects of azidothymidine (a common drug used in treatment of AIDS) in pre-clinical trials (Nageswari, Reddy & Venkatappa, 2018).…”
Section: Immuno-modulatory Activitysupporting
confidence: 66%
“…In the last three decades, extensive research has provided proof of plethora of pharmacological properties of different parts of the plant (Figure 1). T. cordifolia is reported to have array of medicinal properties like-anti-diabetic (Stanely Mainzen Prince & Menon,2000Sonkamble & Kamble, 2015;Chacko, 2018;Khanal et al, 2019;Vora et al, 2020), anti-pyretic (Pendse et al, 1977;Ashok et al, 2010;Hussain et al, 2015;Rakib et al, 2020), hepato-protective (Bishayi et al, 2002;Panchabhai Therapeutics doi:10.31674/book.2021.tkwb et al, 2008Rakib et al, 2020), cardio-protective (Rao et al, 2005;Sharma et al, 2011a;Priya et al, 2017;Begum et al, 2021), neuro-protective (Kosaraju et al, 2014;Sharma & Kaur 2018;Birla et al, 2021), anti-allergic, anti-oxidant (Sharma & Joshi, 2011;Praveen et al, 2012;Prasad & Chauhan, 2019), anti-tumour (Jagetia, Nayak & Vidyasagar, 1998;Jagetia & Rao, 2006;Deepa et al, 2019;Palmieri et al, 2019), radio-protective (Goel et al, 2004;Sharma et al, 2011b;Patel et al, 2013) immuno-modulatory (Bishayi et al, 2002;Nageswari, Reddy & Venkatappa, 2018), anti-ulcer (Sarma et al, 1995;Bairy et al, 2002;Kaur, Singh & Kumar, 2014), anti-fertility…”
Section: Pharmacological Properties Of Tinospora Cordifoliamentioning
confidence: 99%