Evaluation of in vitro and in vivo safety of the by-product of Agave sisalana as a new cosmetic raw material: Development and clinical evaluation of a nanoemulsion to improve skin moisturizing

Barreto, Stella Maria Andrade Gomes; Maia, Mayara Saatmãn; Benicá, Alvaro Moreira; Assis, Hugo Raphael Bezerra Silva de; Leite-Silva, Vânia Rodrigues; Rocha‐Filho, Pedro Alves da; Fernandes-Negreiros, Marília Medeiros; Rocha, Hugo Alexandre de Oliveira; Ostrosky, Elissa Arantes; Lopes, Patrícia Santos; Sales, Valéria Soraya de Farias; Giordani, Raquel Brandt; Ferrari, Márcio

doi:10.1016/j.indcrop.2017.06.064

Cited by 49 publications

(36 citation statements)

References 50 publications

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“…Over the last decade, nanoemulsion-based delivery systems have been gained interest in the pharmaceuticals [1][2][3][4] , food and beverage [5][6][7][8] , cosmetics [9][10][11] , agrochemicals [12][13][14] and other 15 industries. The main purposes are to encapsulate, protect, and deliver lipophilic components such as drugs, vitamins, food supplements, antioxidants, antimicrobials, pesticides.…”

Section: Introductionmentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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Section: Introductionmentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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“…Barreto et al . confirmed the agave polysaccharide extract was without phototoxicity at the dose of nanoemulsion by using this method. 3D reconstructed human epidermis with a UVA dosage of 6 J cm −2 has also been used in the phototoxicity evaluation of multiple emulsions containing mixed herbal actives .…”

Section: Toxicity: In Vitro and In Vivomentioning

confidence: 62%

“…For example, an increased skin penetration of mangosteen ( Garcinia mangostana ) peel extract was reported after encapsulation in nanoparticles because of efficient aggregation of the extract on the epidermis and the lipophilicity of the carrier matrix . Similarly, in a report by Barreto et al , a nanoemulsion formulation of polysaccharide‐enriched by‐product of sisal ( Agave sisalana ) exhibited improved cuticle moisturizing and skin barrier function in the clinical tests with no apparent toxic effects. Furthermore, multilayer emulsion and SLNs have shown to serve as a promising carrier for the simultaneous delivery of hydrophobic and hydrophilic actives in one formulation .…”

Section: Multiple Components/mixed Herbal Extractsmentioning

confidence: 76%

“…For particulate systems, a measurement of phase transition temperature can be used to determine the storage boundary temperature conditions. The stability of emulsions and vesicle/particle dispersions can also be monitored by observing stratification after centrifugation or measuring the change of particle size, zeta potential, pH and conductivity .…”

Section: Storage and Formulation Stabilitiesmentioning

confidence: 99%

“…The phototoxicity of encapsulated ingredients exposed to sunlight can be evaluated by using a validated method, the uptake of neutral red by 3T3 fibroblasts . Barreto et al .…”

Section: Toxicity: In Vitro and In Vivomentioning

confidence: 99%

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Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

Yang

Liu

Han

et al. 2020

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Today, there is a rising demand and ongoing search for novel plant-derived phytochemicals in the cosmetic market owing to the growing consumer expectations worldwide for green and natural health products. Various plant ingredients, including polyphenols, oils, volatile oils, vitamins and other herbal extracts, have been extensively used in herbal cosmetics. Recent advances in encapsulation technologies have greatly improved their chemical stability, biocompatibility, skin permeability and dermocosmetic efficiency when applied topically. This comprehensive review summarizes the up-to-date information on encapsulated plant ingredients tailored for dermocosmetic application with a focus on the development of novel delivery systems. An overview of the commonly used techniques for carrier characterization, performance-related properties and toxicological evaluation is also included, which might provide guidance for researchers to select or develop appropriate assay systems. PolyphenolsPolyphenols are secondary metabolites in plants, and the presence of the array of phenolic hydroxyl groups makes them potent free radical scavengers and antioxidants, which are favoured in antiageing cosmetics [1]. Encapsulation techniques are primarily employed to stabilize the easily reducible polyphenolic compounds during storage and processing, thereby enabling their cosmetic/ pharmaceutical uses. A good example is quercetin, a flavonoid from Sophora japonica L. with a pronounced antioxidative and anti-inflammatory activity but with poor water solubility and low skin

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Phytochemical-Based Formulations for Biomedical Applications

Ramesh,

Palaniappan

2024

Medicinal Applications of Phytopharmaceuticals

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Evaluation of in vitro and in vivo safety of the by-product of Agave sisalana as a new cosmetic raw material: Development and clinical evaluation of a nanoemulsion to improve skin moisturizing

Cited by 49 publications

References 50 publications

Preparation of nanoemulsions by phase inversion temperature (PIT)

Preparation of nanoemulsions by phase inversion temperature (PIT)

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

Phytochemical-Based Formulations for Biomedical Applications

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