Evaluation of in vitro antimicrobial activity of extracts from Cassia obtusifolia L. and Senna sophera (L.) Roxb against pathogenic organisms

Abstract

Cassia species have been of medicinal interest due to their good therapeutic value in folk medicine. In the present study petroleum ether, ethanol and chloroform extracts from leaf and stems of Cassia obtusifolia and Senna sophera were investigated for their antimicrobial activities against some pathogenic microbes in vitro. The C. Obtusifolia leaf extracts in pet ether and chloroform showed more sensitivity against E. faecalis (MIC 0.2725mg/ml and MIC 0.2647) and ethanol extracts against A. fumigatus (MIC 0.3116mg/ml). Similarly the stem extracts of C. Obtusifolia in pet ether showed more sensitivity against E. faecalis (MIC 0.407mg/ml), ethanol extracts against E. faecalis (MIC 0.3009mg/ml) and chloroform extracts against E. faecalis MIC 0.4946mg/ml). The leaf extracts of S. sophera in pet ether showed more sensitivity against C. albicans (MIC 0.3524mg/ml), ethanol extracts against E. faecalis (MIC 0.2738mg/ml) and chloroform extracts against C. Albicans (MIC 0.4239). C. sophera stem extracts in Pet ether showed more sensitivity against E. faecalis (MIC 0.254mg/ml), ethanol extracts against E. faecalis (MIC 0.2987mg/ml) and chloroform extracts against E. faecalis (MIC 0.5899mg/ml). This finding provides an insight into the usage of the leaves of Cassia species in traditional treatment of wounds or burns associated with bacterial and fungal infections. However, further work is needed in the form of phytochemical screening and pharmacological activity of some more extracts before one could conclude anything definite about the therapeutic potential of these extracts.

The Effectiveness of Salvadora persica Extracted Miswak and ZnO NPs on Pathogenic Bacteria

“…The presence of the nanomaterial at a certain concentration in the miswak extract as an antibiotic improves strength of miswak extract as an antibiotic. 20,22…”

“…According to the Clinical and Laboratory Standards Institute (CLSI) standards, all isolates' antimicrobial hindrance plans were analyzed using the reference stock microdilution system. 21,22 PCR upgrade of the mecA quality recognized methicillin impediment in S. aureus and S. epidermidis strains. 23 The revised Hodge test 21 was used to confirm carbapenem resistance in gram-negative bacteria.…”

Phytochemistry, Ethnopharmacological Uses, Biological Activities, and Therapeutic Applications of Cassia obtusifolia L.: A Comprehensive Review

“…faecalis (MIC 0.3009 mg/mL), and chloroform extracts showed sensitivity against E . faecalis MIC 0.4946 mg/mL [ 18 ]. The whole plant extract of C .…”

Antimicrobial activities of Cassia sophera L. extract

“…According to Rahman et al 2017, flower part of the plant showed good antibacterial activity against B. cereus. Deshpande and Naik, (2016) found that leaf and stem extracts of C. obtusifolia in pet ether showed more activity against E. faecalis. The leaf extract of S. sophera in pet ether showed more sensitivity against C. albicans, ethanol extracts against E. faecalis and choloroform extracts against C. albicans.…”

“…Due to the occurrence of various phytoconstituents, the plant is suitable for treating a variety of ailments and has the potential to provide valuable drugs for human use (Tripathi and Kohli, 2012). Traditional wounds or burns, which may occur due to bacteria or fungi, are treatable by the leaf extract of Cassia sophera (Deshpande and Naik, 2016). Although some antimicrobial analyses were carried out different parts of the plant but no systemic researches were done for leaf, flower, seed and stem parts of the plant.…”