Evaluation of in vitro antioxidant effect of new mono and diselenides

4‐Methyl‐2‐prenylphenol (1) was synthesized from para‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their antioxidant properties was carried out using in vitro models. It was established that Mannich base with octylaminomethyl group has radical‐scavenging activity, high Fe2+‐chelation ability as well as the ability to inhibit oxidative hemolysis of red blood cells.

Section: Antioxidant Activity (Brain Lipids Test)mentioning

confidence: 99%

Novel Aminomethyl Derivatives of 4‐Methyl‐2‐prenylphenol: Synthesis and Antioxidant Properties

Буравлев

Федорова

Шевченко

et al. 2019

“…The antioxidant activity of coumarins was evaluated in vitro by the ability to inhibit LPO processes in the brain lipids of laboratory mice. [45,46] After extraction, the brain was homogenized (10 %) in physiological saline (pH = 7.4) and centrifuged for 10 min. Then, supernatant (S1) containing water, proteins, DNA, RNA and lipids (cholesterol, galactolipids, individual phospholipids and gangliosides) was selected.…”

Section: Antioxidant Activity In the Non-cellular Model Systemmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Coumarins withtert‐Butyl and Terpene Substituents

Попова

Шевченко

Chukicheva

et al. 2019

Coumarins with terpene and tert‐butyl substituents were synthesized via Pechmann condensation reaction. New derivatives were investigated in different model system for the exhibition of antioxidant, radical scavenging and membrane‐protective activities. It has been found that 4‐methylcoumarin derivatives with monoterpene moieties exhibit high antioxidant activities. The most active and promising for further investigations is 5‐hydroxy‐6,8‐diisobornyl‐4‐methylcoumarin, containing two isobornyl substituents on the benzopyran ring.

“…Antioxidant activity of the compounds was evaluated on the basis of their ability to inhibit LPO processes in a substrate obtained from the brain of laboratory mice. [48,49] After extraction, the brain was homogenized (10 %) in a saline solution (pH 7.4) and centrifuged for 10 min. Then, the supernatant (S1) [48,50] containing water, proteins, DNA, RNA and lipids was collected.…”

Section: Antioxidant Activity (Test With Brain Lipids)mentioning

confidence: 99%

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

Буравлев

Dvornikova

Schevchenko

et al. 2019

A series of novel esters and amides was synthesized on the basis of para‐coumaric acid containing isobornyl groups in ortho‐positions relative to the phenolic hydroxy group. Antioxidant properties of the obtained compounds were evaluated and compared on in vitro models: radical‐scavenging ability, antioxidant activity on a substrate containing the lipids of animal brain, cytotoxicity of red blood cells, antioxidant and membrane‐protective properties on the model of oxidative red blood cells hemolysis. Statistically significant relationship was established between the antioxidant activity of the studied compounds in model system containing animal lipids and the parameters reflecting their antioxidant properties on the model of H2O2‐induced hemolysis of red blood cells. It was determined that an amide with a morpholine fragment has the highest antioxidant activity. The specified derivative significantly surpassed the reference substances (parent acid, BHT) and was not inferior to the effective antioxidant 2,6‐diisobornyl‐4‐methylphenol in terms of its properties.