Evaluation of in-vitro Thrombolytic activity of methanolic extract of Prunus avium L.

Patel, V K; Manek, Ravi A.; Sheth, Devang

doi:10.5958/2231-5659.2021.00007.2

Cited by 5 publications

(1 citation statement)

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“…The chemical composition of the plant species utilized in this study has not been thoroughly characterized, and the presence or quantity of amino acids or secondary toxic compounds in nectars remains unknown. However, studies have revealed the presence of secondary compounds, such as terpenes, alkaloids, phenols, glycosides, and flavonoids, in flower or leaf extracts of these plant species (Anila & Hashim, 2019 ; Lim, 2014 ; Owolabi et al., 2022 ; Prasad et al., 2011 ; Rout et al., 2008 ). It is uncertain whether, in our no‐choice assays, the mosquitoes indeed consumed nectar rather than phloem or xylem fluids from tissue piercing, as previously observed (Foster, 2022 ; Manda, Gouagna, Nyandat, et al., 2007 ; Müller & Schlein, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

The paradox of plant preference: The malaria vectors Anopheles gambiae and Anopheles coluzzii select suboptimal food sources for their survival and reproduction

Paré,

Hien,

Youba

et al. 2024

Ecology and Evolution

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Anopheles gambiae and Anopheles coluzzii mosquitoes, two major malaria vectors in sub‐Saharan Africa, exhibit selectivity among plant species as potential food sources. However, it remains unclear if their preference aligns with optimal nutrient intake and survival. Following an extensive screening of the effects of 31 plant species on An. coluzzii in Burkina Faso, we selected three species for their contrasting effects on mosquito survival, namely Ixora coccinea, Caesalpinia pulcherrima, and Combretum indicum. We assessed the sugar content of these plants and their impact on mosquito fructose positivity, survival, and insemination rate, using Anopheles coluzzii and Anopheles gambiae, with glucose 5% and water as controls. Plants displayed varying sugar content and differentially affected the survival, sugar intake, and insemination rate of mosquitoes. All three plants were more attractive to mosquitoes than controls, with An. gambiae being more responsive than An. coluzzii. Notably, C. indicum was the most attractive but had the lowest sugar content and offered the lowest survival, insemination rate, and fructose positivity. Our findings unveil a performance–preference mismatch in An. coluzzii and An. gambiae regarding plant food sources. Several possible reasons for this negative correlation between performance and preference are discussed.

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Section: Discussionmentioning

confidence: 99%

The paradox of plant preference: The malaria vectors Anopheles gambiae and Anopheles coluzzii select suboptimal food sources for their survival and reproduction

Paré,

Hien,

Youba

et al. 2024

Ecology and Evolution

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Evaluation of Anti-oxidant, Anti-microbial and Phytochemical analysis of different parts of C. bipinatus

Jasti

Senapathi

Sasank

et al. 2022

RJPT

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Plants are sources of many natural active compounds used to prevent several diseases. The various parts of plants like leaf, stem, flower and root are rich of these bioactive compounds. From ancient times these natural compounds have been using for treatment and prevention of diseases. Cosmos bipinnatus is an herbaceous, medicinal plant. The present study was aimed with the objective to antioxidant, antimicrobial and phytochemical screening, total phenolic and total flavonoid content of different solvent extracts of different parts of Cosmos bipinnatus. Flavonoids were abundantly found in the leaves and the root of Cosmos bipinnatus. Steroids were absent only in the leaves and flowers of Cosmos bipinnatus while terpenoids were completely absent in the flowers of the plant. Alkaloids were absent in the leaves extracted from all the three solvents and root sample extracted using ethyl acetate and stem sample extracted using ethanol. Proteins are absent in all the parts of the plant extracted using all the three solvents namely ethanol, ethyl acetate and hexane. Tannins are absent in the entirely in the flower in addition to the stem sample taken using the solvent hexane. Saponins are present all the parts like leaf, stem and flower but are not found in the root extract of the plant. The total phenolic and flavonoid contents of the extracts were calculated by using the standard gallic acid and quercetin graphs to find out the concentration. The total phenolic content is high for the plant sample stem that is extracted by using hexane as the solvent the value is 790µg/mg. The total flavonoid content is high for the plant sample stem that is extracted by using hexane as the solvent the value is 150µg/mg. The antioxidant activity was also found out by using various assays like FRAP and DPPH where the percentage of inhibition was found out. The highest percentage of inhibition for leaf was found out to be at 120µg/ml with the solvent hexane that is 88.86%. The highest percentage of inhibition for stem was found out to be at 60mg/ml using ethanol that is 89.92%. The highest percentage of inhibition for flower was found out to be at 60mg/ml by ethyl acetate that is 91.42%. The highest percentage of inhibition for root was found out to be at 60mg/ml that is 97%. From the FRAP results it is evident that the antioxidant activity is highest for the root sample.

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Bioactivities of Vitex negundo (Linn) leaf Crude and Fractionated extracts

Sultana

Aovi

Shaima

et al. 2022

RJPT

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In folklore medicine, Vitex negundo leaf is used to treat inflammation, pain, runny nose, itching, tumor etc. Different fractions of crude methanol extract of leaf of Vitex negundo Linn. were tested to evaluate antioxidant, analgesic, thrombolytic, and antibacterial activities. Crude methanol (MeOH) extract and its fractions i.e. petroleum ether (PEFS), CHCl3 (CFS), CCl4 (CTFS), aqueous (AQFS) were subjected to antioxidant activity by DPPH free radical scavenging assay. Analgesic activity was investigated by acetic acid induced writhing method at the dose of 250 and 500mg/kg body weight. Furthermore, thrombolytic activity was evaluated by clot lysis method and antibacterial activity by disk diffusion assay. In DPPH radical scavenging assay, crude extract presented the highest (IC50 value 25µg/ml) radical scavenging activity. Different fractions of extract at the tested doses showed significant (P<0.05) analgesic activity that was comparable to standard diclofenac sodium (80.32 % at 25mg/kg). Also different fractions revealed different range of antibacterial activity against different species of bacteria at different doses. Different fractions of V. negundo leaf disclosed potent antioxidant, thrombolytic, analgesic and antibacterial activities that support the ethnomedical uses of the plant.

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Evaluation of in-vitro Thrombolytic activity of methanolic extract of Prunus avium L.

Cited by 5 publications

References 0 publications

The paradox of plant preference: The malaria vectors Anopheles gambiae and Anopheles coluzzii select suboptimal food sources for their survival and reproduction

The paradox of plant preference: The malaria vectors Anopheles gambiae and Anopheles coluzzii select suboptimal food sources for their survival and reproduction

Evaluation of Anti-oxidant, Anti-microbial and Phytochemical analysis of different parts of C. bipinatus

Bioactivities of Vitex negundo (Linn) leaf Crude and Fractionated extracts

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