Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement

Yu, Yuguo; Wang, Jing; Liu, Changsheng; Zhang, Bingwen; Chen, Honghong; Guo, Han; Zhong, Guoqiang; Qu, Weidong; Jiang, Shize; Huang-yuan, Huang

doi:10.1016/j.colsurfb.2009.12.010

Cited by 104 publications

(67 citation statements)

References 27 publications

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“…The absence of inflammatory manifestations or postoperative infections in any rabbit is similar to the results reported by Yu et al [40] who studied a magnesium phosphate cement as a biodegradable adhesive cement for fracture healing. Overall, the studies suggest that calcium phosphate cements substituted with magnesium are safe, and may have application in fractures fixation.…”

supporting

confidence: 88%

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

Cabrejos-Azama

Alkhraisat

Rueda

et al. 2014

Materials Science and Engineering: C

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We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC) with a twofold purpose: i) to evaluate in vitro the osteoblast cell response to this material, and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPCs in comparison with CPC. The Mg-CPCs have promoted higher new bone formation than the CPC (p < 0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step towards personalized therapy that can adapt to patient needs and clinical situations.

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supporting

confidence: 88%

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

Cabrejos-Azama

Alkhraisat

Rueda

et al. 2014

Materials Science and Engineering: C

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“…Recent studies into magnesium phosphates have been conducted due to higher strengths and faster resorption rates of these cements. Magnesium phosphate cement or ceramic compositions explored to date include [8,[24][25][26][27][28] .…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

Ostrowski

Sharma

Roy

et al. 2015

Journal of Materials Science & Technology

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“…There is enough evidence in the literature that several of the magnesium phosphate (MgP) compounds have the ability to perform as alterative materials to the well‐researched and well‐proven calcium phosphate (CaP) compounds with applications in hard tissue replacements . The history of research in biomedical applications of MgPs is of recent origin, with expansion of research having taken place within last 10 years and there is still a vast amount of knowledge to be learned . Our group has sustained research thrust in this field .…”

Section: Introductionmentioning

confidence: 99%

“…3 The history of research in biomedical applications of MgPs is of recent origin, with expansion of research having taken place within last 10 years and there is still a vast amount of knowledge to be learned. [4][5][6][7] Our group has sustained research thrust in this field. [8][9][10][11][12] This paper aims to synthesize and characterize newberyite (MgHPO 4 Á3H 2 O), an important bioceramic material in the MgO-P 2 O 5 binary system.…”

Section: Introductionmentioning

confidence: 99%

Microwave assisted synthesis and characterization of single‐phase tabular hexagonal newberyite, an important bioceramic

Sikder

Bhaduri

2018

J Am Ceram Soc

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Magnesium phosphate compounds such as newberyite (MgHPO4·3H2O) and struvite (MgNH4PO4·6H2O) are becoming important alternatives to calcium phosphates in hard tissue replacements. So far, newberyite has received lesser attention with respect to struvite. Therefore, the broad aim of this paper is to report an easy synthesis technique and characterization of single‐phase newberyite, which may have diverse uses as a bioceramic material. Specifically, we describe a simple and robust microwave‐assisted process for the synthesis of single‐phase newberyite in tabular hexagonal form. Second, we soak the newberyite powders in simulated body fluid, a solution which mimics the pH and ion concentration of human blood plasma, for 7 days and analyze the apatite formation on the crystals. Third, we report that single‐phase newberyite, by itself, does not possess antibacterial property.

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Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement

Cited by 104 publications

References 27 publications

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

Microwave assisted synthesis and characterization of single‐phase tabular hexagonal newberyite, an important bioceramic

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