Evaluation of inhibitory effect of Saliva officinalic extracts and volatile oils on the life of Leishmania donovani parasite

Abstract

Visceral leishmaniasis (VL) is considered one of the endemic diseases in Iraq, and due to the distinction of the anti-leishmaniasis treatments currently used by their many side effects in addition to their toxicity to the human body, as well as the length of treatment period, and the problems they cause to the digestive system, Salvia officinalis (Saga) was used as a natural preventive treatment against leishmaniasis. Because of its therapeutic properties for many health symptoms, including heart attacks, ulcers, and cancerous tumors, in addition to its antibacterial and antimicrobial nature, the current study aimed to know the inhibitory activity of plant extracts and the volatile oil of Salvia officinalis on the life of Leishmania donovani parasite, using the colorimetric test (MTT assay, to measure toxicity) promastigote parasitoid cells, six concentrations of the aqueous extract and plant emulsion of the mentioned plant were prepared (6.25, 12.5, 25, 50, 100, 200) g/mlµ, the concentrations of the volatile oil were (31.25 ,62.5, 125, 250, 500 1000) g/mlµ, The results indicated that under the influence of treatment with the three drug spectra of Salvia officinalis, there were noticeable differences in the inhibitory percentage for each drug spectrum.