Evaluation of insulin like growth factor-1 (IGF-1) level and its impact on muscle and bone mineral density in frail elderly male

Mohamad, Magda I.; Khater, Mohamed

doi:10.1016/j.archger.2014.08.011

Cited by 26 publications

(15 citation statements)

References 26 publications

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“…Mohamad et al. reported that lower IGF‐1 level in older adults might be associated with the risk of being frail and having abnormal BMD . In the present study, IGF‐1 level and femoral neck BMD were significantly decreased in the frail and pre‐frail group.…”

Section: Discussionsupporting

confidence: 52%

Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Chang

Hsu

Huang

et al. 2017

Geriatrics Gerontology Int

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Section: Discussionsupporting

confidence: 52%

Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Chang

Hsu

Huang

et al. 2017

Geriatrics Gerontology Int

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“…The conditional knock-out induced during adulthood suggests that this loss is detrimental to bone aging. Moreover, clinical studies indicate that reduced levels of IGF-1 are associated with decreased bone mineral density (Gillberg et al 2002;Janssen et al 1998;Kurland et al 1997;Langlois et al 1998;Mohamad and Khater 2015;Rhee et al 2004;Sugimoto et al 1997;Szulc et al 2004) and increased risk of osteoporosis in advanced age (Kurland et al 1997;Liu et al 2008;Paccou et al 2012;Sugimoto et al 1997). Considering this, it is possible that early-life deficiency in IGF-1 may have differing effects on bone aging than deficiency induced later in life.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice

Ashpole

Herron

Estep

et al. 2016

AGE

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Advanced aging is associated with the loss of structural and biomechanical properties in bones, which increases the risk for bone fracture. Aging is also associated with reductions in circulating levels of the anabolic signaling hormone, insulin-like growth factor (IGF)-1. While the role of IGF-1 in bone development has been well characterized, the impact of the age-related loss of IGF-1 on bone aging remains controversial. Here, we describe the effects of reducing IGF-1 at multiple time points in the mouse life span--early in postnatal development, early adulthood, or late adulthood on tibia bone aging in both male and female igf (f/f) mice. Bone structure was analyzed at 27 months of age using microCT. We find that age-related reductions in cortical bone fraction, cortical thickness, and tissue mineral density were more pronounced when IGF-1 was reduced early in life and not in late adulthood. Three-point bone bending assays revealed that IGF-1 deficiency early in life resulted in reduced maximum force, maximum bending moment, and bone stiffness in aged males and females. The effects of IGF-1 on bone aging are microenvironment specific, as early-life loss of IGF-1 resulted in decreased cortical bone structure and strength along the diaphysis while significantly increasing trabecular bone fraction and trabecular number at the proximal metaphysis. The increases in trabecular bone were limited to males, as early-life loss of IGF-1 did not alter bone fraction or number in females. Together, our data suggest that the age-related loss of IGF-1 influences tibia bone aging in a sex-specific, microenvironment-specific, and time-dependent manner.

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“…Numerous clinical studies have reported a close association between circulating IGF-1 and bone mineral density (11–18) . During adolescence the rise in circulating IGF-1 that occurs in both rodents and humans is highly correlated with bone formation and skeletal growth.…”

Section: Introductionmentioning

confidence: 99%

“…(5)(6)(7)(8)(9)(10) Numerous clinical studies have reported a close association between circulating IGF-1 and bone mineral density. (11)(12)(13)(14)(15)(16)(17)(18) During adolescence the rise in circulating IGF-1 that occurs in both rodents and humans is highly correlated with bone formation and skeletal growth. Similarly, an absence of IGF-1 (eg, in homozygous IGF-1 knockout mice) results in a significant retardation of bone and overall body growth as well as a variety of other complications that ultimately lead to premature death.…”

Section: Introductionmentioning

confidence: 99%

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

Ashpole

Herron

Mitschelen

et al. 2015

Journal of Bone and Mineral Research

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Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular bone structure. Aging is also associated with a reduction in circulating levels of insulin-like growth factor (IGF-1). Studies have suggested that the reduction in IGF-1 compromises healthspan, while others report that loss of IGF-1 is beneficial as it increases healthspan and lifespan. To date, the effect of decreases in circulating IGF-1 on vertebral bone aging has not been thoroughly investigated. Here, we delineate the consequences of a loss of circulating IGF-1 on vertebral bone aging in male and female Igff/f mice. IGF-1 was reduced at multiple specific time points during the mouse lifespan- early in postnatal development (crossing albumin-Cre mice with Igff/f mice), or early adulthood, and late adulthood using hepatic-specific viral vectors (AAV8-TBG-Cre). Vertebrae bone structure was analyzed at 27 months of age using microCT and quantitative bone histomorphometry. Consistent with previous studies, both male and female mice exhibited age-related reductions in vertebral bone structure. In male mice, reduction of circulating IGF-1 induced at any age did not diminish vertebral bone loss. Interestingly, early-life loss of IGF-1 in females resulted in a 67% increase in vertebral bone volume fraction, as well as increased connectivity density and increased trabecular number. The maintenance of bone structure in the early-life IGF-1-deficient females was associated with increased osteoblast surface and an increased ratio of osteoprotegerin/receptor-activator of NFkB-ligand levels in circulation. Within 3 months of a loss of IGF-1, there was a 2.2 fold increase in insulin receptor expression within the vertebral bones of our female mice, suggesting that local signaling may compensate for the loss of circulating IGF-1. Together, these data suggest the age-related loss of vertebral bone density in females can be reduced by modifying circulating IGF-1 levels early in life.

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Evaluation of insulin like growth factor-1 (IGF-1) level and its impact on muscle and bone mineral density in frail elderly male

Cited by 26 publications

References 26 publications

Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

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