Evaluation of Interleukin 19 level in acne vulgaris patients

Abstract

Introduction: Acne vulgaris is a disease that affects youth. The majority of patients present with various types of lesions, including papules, comedones, pustules, and nodules. Many criteria are present in the pathogenesis of acne, like increased keratinization of the follicle, abnormal follicular desquamation, high sebum secretion, proliferation of bacteria, inflammation, and a genetic role. IL-19 is a cytokine secreted by skin cells that initiates stimulation before inflammation. IL-19 is characterized by the ability of positive feedback to be magnified when activated during inflammation. They provide cytokines and aid in the inflammatory process. Aim of the study:To detect the level of interleukin 19 in the serum of mild acne vulgaris cases. Subjects and Methods:The study included 40 patients with mild acne and 100 healthy controls. Three ml of blood were collected from each participant in plain tubes, where the serum was separated and used for estimation of the IL-19 concentration level. Results:The study revealed that there is a high increase in interleukin-19 levels in mild acne patients compared to normal controls. Conclusion:This study suggested that there is a possible correlation between the serum level of interleukin 19 and acne vulgaris pathogenesis.