Introduction: Acne vulgaris is a disease that affects youth. The majority of patients present with various types of lesions, including papules, comedones, pustules, and nodules. Many criteria are present in the pathogenesis of acne, like increased keratinization of the follicle, abnormal follicular desquamation, high sebum secretion, proliferation of bacteria, inflammation, and a genetic role. IL-19 is a cytokine secreted by skin cells that initiates stimulation before inflammation. IL-19 is characterized by the ability of positive feedback to be magnified when activated during inflammation. They provide cytokines and aid in the inflammatory process. Aim of the study:To detect the level of interleukin 19 in the serum of mild acne vulgaris cases. Subjects and Methods:The study included 40 patients with mild acne and 100 healthy controls. Three ml of blood were collected from each participant in plain tubes, where the serum was separated and used for estimation of the IL-19 concentration level. Results:The study revealed that there is a high increase in interleukin-19 levels in mild acne patients compared to normal controls. Conclusion:This study suggested that there is a possible correlation between the serum level of interleukin 19 and acne vulgaris pathogenesis.

Introduction: Systemic lupus erythematosus (SLE) is considered an autoimmune skin disorder in which the immune system attacks its own tissues, causing widespread inflammation and damage to the tissues. Aim of the study:To compare and measure the serum level of midkine (MK) in patients with SLE and compare it with healthy controls, as well as analyze the relationship between disease activity in SLE and the level of MK in serum and to early diagnose whether patients were nephritis or nonnephritis SLE patients.Subjects and Methods: Ninety subjects were included in this study, subdivided equally into three groups, 30 healthy-matched individuals and 60 SLE patients (Nephritis and non-Nephritis patients). For all groups, a 5mL blood sample for serum isolation was taken and analyzed by using the ELISA technique to measure the level of MK. Results:The midkine levels were high in both nephritis and non-nephritis as compared to controls (P= 0.001 and 0.015, respectively). There was a positive correlation between midkine level and ESR in nephritis patients. There was no correlation between midkine and other clinical data among non-nephritis patients, P> 0.05. Based on the disease severity classification, the serum level of midkine is higher in severe patients than in other groups. Regarding disease duration, we reported that midkine tended to be very high in patients with a duration of 12 months, 2021.76±813.57 then slightly decreased to 830.69±104.50 in duration between 12 and 24 months. The level of midkine increased again to 1357.86±436.42 for duration>24. Conclusion:It can be concluded that MK can be used to early diagnose SLE patients and differentiate between nephritis versus non-nephritis patients.