Evaluation of intrafraction motion of the organs at risk in image-based brachytherapy of cervical cancer

Simha, Vijai; Patel, Firuza D.; Sharma, Suresh C.; Rai, Bhavana; Oinam, Arun S; Krishnatry, Rahul; Dhanireddy, Bhaswanth

doi:10.1016/j.brachy.2014.05.016

Cited by 18 publications

(21 citation statements)

References 15 publications

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“…In physical doses, these random variations appeared more than 20% for the three organs, similar to that reported in our PDR experience (Table 2). Simha et al (21) recently reported their experience of motion evaluation in between image acquisition and treatment delivery (HDR, 4 Â 7 Gy to D 90 HR-CTV). They acquired an MRI for treatment planning purposes and 2 h after a CT scan.…”

Section: Discussionmentioning

confidence: 98%

Intrafractional organs movement in three-dimensional image-guided adaptive pulsed-dose-rate cervical cancer brachytherapy: Assessment and dosimetric impact

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Intrafractional organs movement in three-dimensional image-guided adaptive pulsed-dose-rate cervical cancer brachytherapy: Assessment and dosimetric impact

et al. 2015

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“…Intra-fractional organs deformations can be named as a major source of uncertainties during HDR 192 Ir intracavitary brachytherapy for cervical cancer patients [ 6 , 30 , 31 ]. Online treatment planning correction is reasonable based on these days’ improvements on image guidance in brachytherapy rooms [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Intra-fractional organs at risk (OARs) deformations that can lead to their dose variation during IGABT have been studied by other researchers. They reported these variations as one of the most important uncertainty factors of gynaecological (GYN) brachytherapy [ 6 , 7 ]. However, quality control of dose delivery in IGABT is an image-assistance procedure [ 8 , 9 ].…”

Section: Purposementioning

confidence: 99%

Artificial neural network based gynaecological image-guided adaptive brachytherapy treatment planning correction of intra-fractional organs at risk dose variation

Jaberi¹,

Siavashpour²,

Aghamiri³

et al. 2017

jcb

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PurposeIntra-fractional organs at risk (OARs) deformations can lead to dose variation during image-guided adaptive brachytherapy (IGABT). The aim of this study was to modify the final accepted brachytherapy treatment plan to dosimetrically compensate for these intra-fractional organs-applicators position variations and, at the same time, fulfilling the dosimetric criteria.Material and methodsThirty patients with locally advanced cervical cancer, after external beam radiotherapy (EBRT) of 45-50 Gy over five to six weeks with concomitant weekly chemotherapy, and qualified for intracavitary high-dose-rate (HDR) brachytherapy with tandem-ovoid applicators were selected for this study. Second computed tomography scan was done for each patient after finishing brachytherapy treatment with applicators in situ. Artificial neural networks (ANNs) based models were used to predict intra-fractional OARs dose-volume histogram parameters variations and propose a new final plan.ResultsA model was developed to estimate the intra-fractional organs dose variations during gynaecological intracavitary brachytherapy. Also, ANNs were used to modify the final brachytherapy treatment plan to compensate dosimetrically for changes in ‘organs-applicators’, while maintaining target dose at the original level.ConclusionsThere are semi-automatic and fast responding models that can be used in the routine clinical workflow to reduce individually IGABT uncertainties. These models can be more validated by more patients’ plans to be able to serve as a clinical tool.

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“…Recent advances in magnetic resonance imaging-guided image-based brachytherapy have allowed us to conform the brachytherapy dose to both volume (three-dimensional) and time (four-dimensional) [1,2]. Repeated imaging is advised for each fraction, as significant dose variation may occur due to the inter-fraction and intra-fraction variation in the organs at risk (OAR) doses [3,4]. Inter-fraction dose variation may occur due to geometrical variations or organ deformation.…”

Section: Introductionmentioning

confidence: 99%

Bladder–Rectum Spacer Balloon versus Vaginal Gauze Packing in High Dose Rate Brachytherapy in Cervical Cancer: A Randomised Study (Part II)

et al. 2015

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Evaluation of intrafraction motion of the organs at risk in image-based brachytherapy of cervical cancer

Cited by 18 publications

References 15 publications

Intrafractional organs movement in three-dimensional image-guided adaptive pulsed-dose-rate cervical cancer brachytherapy: Assessment and dosimetric impact

Intrafractional organs movement in three-dimensional image-guided adaptive pulsed-dose-rate cervical cancer brachytherapy: Assessment and dosimetric impact

Artificial neural network based gynaecological image-guided adaptive brachytherapy treatment planning correction of intra-fractional organs at risk dose variation

Bladder–Rectum Spacer Balloon versus Vaginal Gauze Packing in High Dose Rate Brachytherapy in Cervical Cancer: A Randomised Study (Part II)

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