Evaluation of iron chelating and antioxidant potential of Epilobium hirsutum for the management of iron overload disease

Sheikh, N. A.; Desai, T. R.; Tirgar, Pravin

doi:10.1016/j.biopha.2017.02.079

Cited by 15 publications

(14 citation statements)

References 30 publications

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“…Likewise, radical scavenging activity has been noticed even in the leaves of E. hirsutum methanolic extract (Jamous et al, ). Furthermore, the potential antioxidant activity through iron chelation was significant and was better evidenced at a high dose (300 mg/kg) and for at least 30 days (Sheikh, Desai, & Tirgar, ). These antioxidant and chemoprotective effects of E. hirsutum have been confirmed also for ellagic acid, by in vivo studies.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Epilobium spp: Pharmacology and Phytochemistry

Vitalone

Allkanjari

2018

Phytotherapy Research

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The Epilobium species and their extracts are very popular in folk medicine, for a wide range of applications. The purpose of this review is the analysis of the pharmacological properties of Epilobium spp, considering whether their effects (e.g., anti-inflammatory, antioxidant, antitumor, antimicrobial, analgesic, and antiandrogenic) could rationally justify the use of Epilobium as a treatment of numerous diseases. Even if numerous preclinical studies have been reported, randomized controlled clinical trials (for the evaluation of safety and efficacy), and eventually cost-effectiveness studies (to estimate the long-term cumulative costs), are still needed to confirm the usefulness of these medicinal plants in human diseases.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Epilobium spp: Pharmacology and Phytochemistry

Vitalone

Allkanjari

2018

Phytotherapy Research

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“…For example, E. angustifolium and E. hirsutum are known as yaki otu and are used to treat prostate diseases in Turkey [8,9]. Moreover, E. hirsutum is used to stop bleeding [10] in the treatment of gastrointestinal problems, menstrual disorders, and sleeping problems [11][12][13][14]. In addition, the young leaves of the Epilobium species are often used as food and feed [11,15].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the young leaves of the Epilobium species are often used as food and feed [11,15]. To confirm the ethnobotanical uses of the species, several pharmacological and biochemical studies on the members of the genus have been performed [13,[16][17][18][19][20][21][22]. In addition to these pharmacological studies, the presence of biologically active compounds including tannins (especially ellagitannins), myricetin, quercetin, and several phenolic acids have been reported in phytochemical studies [18,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Zengin

Mahomoodally

et al. 2021

Antioxidants

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Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging/reducing assays, the methanol, infusion, and methanol/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNFα. The interaction between TNFα and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNFα was reduced in PC3 cells after exposure to methanol and methanol/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.

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“…It has been proposed that copper ions accumulation boosts ROS generation via Fenton‐like reactions . Accordingly, the search for antioxidants able not only of scavenging ROS but also of chelating metal ions has become an active area of research …”

Section: Introductionmentioning

confidence: 99%

Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

Castañeda‐Arriaga

Pérez-González

Álvarez-Idaboy

et al. 2017

Int J of Quantum Chemistry

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Oxidative damage to biomolecules is a serious health-threatening issue, which leads to the development of several diseases. Oxidative conditions are frequently catalyzed by metal ions. In this study, the role of purines in the copper-catalyzed oxidative stress was investigated using the density functional theory. The obtained results indicate that purines can have a dual behavior, acting as both protectors and promoters of oxidative stress. Their protection role arises from their known radical scavenging activity, as well as their ability to chelate Cu(II) leading to complexes that areto some extent-harder to reduce than free Cu(II). Conversely, their pro-oxidant role is a consequence of their reductant behavior, when deprotonated. Thus, the purines' anions can reduce Cu (II) to Cu(I), making the latter available to be involved in Fenton-like reactions. Consequently, mixtures of purines and Cu(II), at pHs where the fraction of deprotonated purines is rather significant, would yield • OH radicals. In turn, these very reactive radicals would damage biological targets such as lipids, proteins, and DNA.antioxidants, kinetics, pro-oxidants, rate constants, reaction mechanism 1 | I N TR ODU C TI ON Oxidative damage (OD) to biological targets such as lipids, proteins, and DNA is a serious health-threatening phenomenon. It has been held responsible, at least in part, for the onset and development of several diseases including cancer [1][2][3] ; rheumatoid arthritis [4][5][6] ; neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, depression, multiple sclerosis, and memory loss [7][8][9][10][11][12][13] ; cardiovascular diseases such as atherosclerosis, ischemia, hypertension, cardiac hypertrophy, heart failure, and cardiomyopathy [14][15][16][17] ; as well as renal [18][19][20] and pulmonary failure. [21][22][23] OD arises as a consequence of a chemical imbalance between the production and consumption of oxidants, known as oxidative stress (OS). [24] One of the most damaging oxidants in biological systems is the hydroxyl radical ( • OH). It can be produced, in the presence of metal ions such as Fe(II) or Cu(I), by Fenton or Fenton-like reactions (M q 1 H 2 O 2 ! M q11 1OH -1 • OH). However, the most stable and abundant forms of these two metals, under physiological conditions, are Fe(III) and Cu(II). Thus, • OH production would actually involve the metal-catalyzed Haber-Weiss recombination (HWR). It comprises two chemical steps. The first one is the reduction of the metal ions (M q11 1 O •2 2 ! M q 1 3 O 2 ) and the second one is the Fenton reaction. Consequently, redox active metal ions are of particular interest for the chemistry of living systems. These ions cannot only bind to DNA, but they can also promote OD to DNA by mediating the production of oxygen reactive species (ROS). [25] In fact metal-mediated OD to DNA has become an important topic in metal toxicity and carcinogenesis. [26][27][28][29]

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Evaluation of iron chelating and antioxidant potential of Epilobium hirsutum for the management of iron overload disease

Cited by 15 publications

References 30 publications

Epilobium spp: Pharmacology and Phytochemistry

Epilobium spp: Pharmacology and Phytochemistry

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

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