Evaluation of larvicidal activity and ecotoxicity of linalool, methyl cinnamate and methyl cinnamate/linalool in combination against Aedes aegypti

Fujiwara, Gislene Mari; Annies, Vinicius; Oliveira, Camila Freitas de; Lara, Ricardo A.; Gabriel, Maria Madalena; Betim, Fernando César Martins; Nadal, Jéssica Mendes; Farago, Paulo Vítor; Dias, June Ferraz; Miguel, Obdúlio Gomes; Miguel, Marílis Dallarmi; Marques, Francisco A.; Zanin, Sandra Maria Warumby

doi:10.1016/j.ecoenv.2017.01.046

Cited by 73 publications

(57 citation statements)

References 45 publications

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“…Linalool showed high larvicidal activity against third‐stage larvae of Ae. aegypti , the LC 50 value of linalool was 275.2 μg/mL and the LC 90 value was 442.8 μg/mL . Silva et al .…”

Section: Discussionmentioning

confidence: 96%

Chemical composition and larvicidal activity against Aedes mosquitoes of essential oils from Arisaema fargesii

Huang

Lin

Jia

et al. 2019

Pest Management Science

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BACKGROUND: Dengue fever is caused by the spread of dengue virus by Aedes mosquito vectors. Currently, the most effective way to control dengue is by preventing mosquitoes from spreading the disease. Arisaema fargesii is a Chinese herbal medicine commonly used to repel mosquitoes. In our laboratory, anti-mosquito chemical components were extracted from A. fargesii, and the effects of these substances on mosquito larvae were examined. RESULTS: In total, 48 compounds corresponding to 98.79% of the total oil were identified and the major compounds identified were linalool (12.38%), carvacrol (8.27%), eugenol (5.21%), and -selinene (5.36%). Essential oil had larvicidal activity against Ae. aegypti and Ae. albopictus with LC 50 values of 40.49 mg/L, 47.01 mg/L, respectively. The LC 50 values of carvacrol, eugenol, linalool and -selinene were 32.78, 56.34, 70.56, 136.03 mg/L against Ae. aegypti larvae, and 39.08, 52.07, 82.34, 151.74 mg/L, respectively, against Ae. albopictus larvae. Biochemical assays of Aedes larvae showed that the activities of acetylcholinesterase (AChE), monooxygenases (MO), glutathione-S-transferase (GST), p-Nitrophenyl acetate (p-NPA) esterase, -esterase and -esterase were significantly affected by carvacrol. Essential oil induced the detoxification mechanism for the action of GST and MO.CONCLUSION: The result indicates that essential oil of A. fargesii and its isolated constituent have good inhibitory effects on the defense enzymes of Aedes mosquito larvae. A. fargesii essential oil can be used to control Aedes mosquito larvae to prevent the spread of dengue fever. /journal/ps a Retention index relative to n-alkanes on HP-5 MS capillary column. b Relative area (peak area relative to the total peak area). c RI, retention index, MS, mass spectrum, Co, co-injection with authentic compound. Pest Manag Sci 2020; 76: 534-542

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“…Linalool showed high larvicidal activity against third‐stage larvae of Ae. aegypti , the LC 50 value of linalool was 275.2 μg/mL and the LC 90 value was 442.8 μg/mL . Silva et al .…”

Section: Discussionmentioning

confidence: 96%

Chemical composition and larvicidal activity against Aedes mosquitoes of essential oils from Arisaema fargesii

Huang

Lin

Jia

et al. 2019

Pest Management Science

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“…The essential oil of O. carnosum, which has linalool as the major constituent, exhibited larvicidal activity, with LC 50 value of 109.49 ± 0.35 μg/mL. In previous studies, Jantan et al (2005et al ( ), Pandey et al (2013 and Fujiwara et al (2017) evaluated the larvicidal activity of linalool against Ae. aegypti, and observed LC 50 values of 157.4, 242.6 and 275.2 μg/mL, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Aedes aegypti Linnaeus (Diptera: Culicidae) is the main vector of dengue, chikungunya, and Zika virus. This species is widely distributed in the tropical and subtropical countries, where environmental and climatic conditions of temperature and humidity allow its proliferation (Jansen & Beebe 2010, Fujiwara et al 2017. In addition, the geographical range of Ae.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum

Ricarte

Bezerra

Romero

et al. 2020

An. Acad. Bras. Ciênc.

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The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval bioassay against Aedes aegypti of V. agnus-castus, O. campechianum and O. carnosum essential oils showed LC 50 values of 97.55 ± 0.35, 81.45 ± 0.35 and 109.49 ± 0.35 μg/mL, respectively. The in vitro cytotoxic activities of the essential oils has been evaluated on breast adenocarcinoma (MCF-7), lung carcinoma (NCI-H292), pro-myelocytic leukemia (HL-60), and cervical adenocarcinoma (HEP-2) human cell lines, and pro-myelocytic leukemia cells lines (HL-60) were found to be the most sensitive to all the essential oils tested than the others. This is the first report on larvicidal and cytotoxic activities of these essential oils.

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“…The methodology applied was adapted from the World Health Organization 2005and Fujiwara et al (2017). The eggs of Aedes aegypti (eggs from the Rockefeller strain made available by Oswaldo Cruz Foundation -Fiocruz) were placed in dechlorinated water and incubated in a B.O.D incubator at a controlled temperature of 27°C and relative humidity of 80%.…”

Section: Toxicity Against Aedes Aegyptimentioning

confidence: 99%

Ocotea nutans (Nees) Mez (Lauraceae): chemical composition, antioxidant capacity and biological properties of essential oil

Betim

Oliveira

Souza

et al. 2019

Braz. J. Pharm. Sci.

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The present study was undertaken to assess the potential uses of the essential oil obtained from Ocotea nutans (Nees) Mez. The hydrodistilled essential oil from O. nutans leaves was analyzed by gas chromatography-mass spectrometry. Fifty-eight compounds representing 87,29% of the total leaf essential oil components were identified, of which biciclogermacrene(11.41%), germacrene-D (4.89%), bisabolol-11-ol(3.73%) and spathulenol (3.71%) were the major compounds. The essential oil from O. nutans were tested for antibacterial activity using the minimum inhibitory concentracion (MIC) method, Artemia salina method, larvicidal activity in Aedes aegypti, and antioxidant capacity.The antioxidant activity measured by the phosphomolybdenum complex and Prussian blue method had positive results. The minimum inhibitory concentration for the microorganisms tested allowed moderate inhibitionfor Enterococcus faecalis (MIC=500 µg/mL). Artemia salina were toxic to the organisms in the study (LC 50 = 71,70 μg /mL). The essential oil showed remarkable larvicidal activity potencial (LC 50 = 250 µg/mL). The present results showed that O. nutans essential oil has potential biological uses.

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Evaluation of larvicidal activity and ecotoxicity of linalool, methyl cinnamate and methyl cinnamate/linalool in combination against Aedes aegypti

Cited by 73 publications

References 45 publications

Chemical composition and larvicidal activity against Aedes mosquitoes of essential oils from Arisaema fargesii

Chemical composition and larvicidal activity against Aedes mosquitoes of essential oils from Arisaema fargesii

Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum

Ocotea nutans (Nees) Mez (Lauraceae): chemical composition, antioxidant capacity and biological properties of essential oil

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