Evaluation of laser capsule polishing for prevention of posterior capsule opacification in a human ex vivo model

Luft, Nikolaus; Kreutzer, Thomas C.; Dirisamer, Martin; Priglinger, Claudia; Bürger, Johannes; Findl, Oliver; Priglinger, Siegfried

doi:10.1016/j.jcrs.2015.06.039

Cited by 19 publications

(13 citation statements)

References 19 publications

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“…In a survey conducted in 2003 by AAPOS, more than 50% of respondents worldwide preferred this combination: a vitrector for very young patients and manual anterior capsulotomy for older children [55,56]. Some surgeons "polish" the lens capsule in an attempt to minimise lens epithelial cell reproliferation [57,58]. 23g vitrectomy is now most commonly used, enabling aspiration of adherent lens matter through smaller incisions [59].…”

Section: Basic Surgical Techniquesmentioning

confidence: 99%

Cataract management in children: a review of the literature and current practice across five large UK centres

Self

Taylor

Solebo

et al. 2020

Eye

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Congenital and childhood cataracts are uncommon but regularly seen in the clinics of most paediatric ophthalmology teams in the UK. They are often associated with profound visual loss and a large proportion have a genetic aetiology, some with significant extra-ocular comorbidities. Optimal diagnosis and treatment typically require close collaboration within multidisciplinary teams. Surgery remains the mainstay of treatment. A variety of surgical techniques, timings of intervention and options for optical correction have been advocated making management seem complex for those seeing affected children infrequently. This paper summarises the proceedings of two recent RCOphth paediatric cataract study days, provides a literature review and describes the current UK 'state of play' in the management of paediatric cataracts.

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Section: Basic Surgical Techniquesmentioning

confidence: 99%

Cataract management in children: a review of the literature and current practice across five large UK centres

Self

Taylor

Solebo

et al. 2020

Eye

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“…Various means to destroy LECs, such as mitosis, heating, freezing, laser and trypsin, are not applicable. [32] In animal studies, LECs growth was inhibited with IOLs incubated in celecoxib. [33] Trypsin damages other structure in the anterior polar of eyeball.…”

Section: Discussionmentioning

confidence: 99%

Effect of anterior capsule polish on visual function: A meta-analysis

Han

Yuan

et al. 2019

PLoS ONE

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PurposeTo investigate the relationship between anterior capsule polish and visual function.MethodsData were obtained from Pubmed, Embase, Web of Science, WanFang, VIP and CNKI up to the end of May 2018, without any date or language restrictions for trials. The modified Jadad scale and the newcastle-ottawa scale were used to assess the quality of included studies. Uncorrected visual acuity (UCVA) and posterior capsule opacification (PCO) were used as outcome variables. Data on anterior capsule polish were pooled using weighted, random-effect meta-analysis.ResultsOne randomized controlled trial and 4 observational cohort studies involving 2533 patients were included in the analyses. There was a statistically significant difference of UCVA (OR 1.92, 95% CI 1.41–2.61) between the polish group and the control group, indicating that anterior capsule polish improved UCVA. Further studies with continuous data also suggested that anterior capsule polish was associated with good UCVA (MD 0.11, 95% CI 0.06–0.16). Posterior capsule opacification rate for 1-year or longer follow-up were extracted for 2561 eyes in 3 studies. Posterior capsule opacification rate was lower in the anterior capsule polish group according to summary odds ratio on PCO rate (OR 0.42 95% CI 0.24–0.73).ConclusionsAnterior capsule polish prevents complication of modern cataract surgery and benefits on visual function in short term follow-up period.

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“…[11] Efforts have been made to decrease the LECs population intraoperatively by various means. These means include sealed irrigation capsular device,[5] proper hydrodissection,[4] ultraviolet treatment of LECs,[7] laser capsule polishing,[12] and irrigation of capsular bag by trypan blue dye. [8] Injection of sustainable cyclosporin-A in the capsular bag,[13] and the cytoskeletal drugs H-7 and Latrunculin B,[14] have also been used for decreasing LEC population in the experimental studies.…”

Section: Discussionmentioning

confidence: 99%

Rotation versus non-rotation of intraocular lens for prevention of posterior capsular opacification

Joshi

Chavan

2019

Indian J Ophthalmol

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Purpose: To study the effect of rotation of intraocular lens (IOL) on posterior capsular opacification (PCO) in eyes with phacoemulsification. Methods: This was a prospective, comparative, randomized case series. One eye of each patient was randomized to one of two groups. The 360-degree rotation of IOL was carried out after its placement in the capsular bag (rotation group). The control group had no rotation of IOL. PCO was analyzed by an independent observer on EPCO computer analysis system at 6, 12, 24, and 36 months. Results: The study included 50 patients (100 eyes) with senile cataracts scheduled for phacoemulsification and IOL implantation. The median age in 2 groups was 66 years. 25% quartile age in both the group was 62 years ( P = 0.06). There were 30 males, and 20 females. The median PCO score at 6, 12 and 24 months was significantly low in the rotation group (0.15, 0.13, 0.22) compared to the control group (0.22, 0.23, 0.25). There was no significant difference in PCO score between the two groups from 24-36 months. The median PCO score at 36 months was 0.2 in both the groups. At the end of three years, 4 eyes (8%) in the rotation group, and 10 eyes (20%) in the control group needed Nd:YAG capsulotomy ( P = 0.04). Conclusion: Rotation of IOL in the capsular bag decreases PCO and Nd:YAG capsulotomy rate.

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Evaluation of laser capsule polishing for prevention of posterior capsule opacification in a human ex vivo model

Abstract: The authors have no proprietary or financial interest in any of the materials or equipment mentioned in this study.

Cited by 19 publications

References 19 publications

Cataract management in children: a review of the literature and current practice across five large UK centres

Cataract management in children: a review of the literature and current practice across five large UK centres

Effect of anterior capsule polish on visual function: A meta-analysis

Rotation versus non-rotation of intraocular lens for prevention of posterior capsular opacification

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