Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study

Okayama, Satoshi; Nakano, Tomoya; Uemura, Shiro; Fujimoto, Shinichi; Somekawa, Satoshi; Watanabe, Makoto; Nakajima, Tamio; Saito, Yoshihiko

doi:10.1186/1532-429x-15-87

Cited by 21 publications

(18 citation statements)

References 19 publications

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“…4) The LV volume change at 30% and 50% of the diastolic duration (defined as the temporal interval between T ESV to end of the R-R interval) normalized to stroke volume (SV) was defined as the diastolic index at 30% (DI 30% ) and 50% (DI 50% ), respectively. 26 5) EFP was defined as the temporal interval between ESV and the onset of atrial contraction (estimated from the dV/dt curve), and the LFP was defined as the interval between the onset and end of atrial contraction. 6) The peak early filling rate (R EFP ) and peak late filling rate (R LFP ) were identified as the peak positive volume rates during EFP and LFP, respectively (corresponding to E and A peaks in Doppler echocardiographic peak filling velocities during mitral inflow).…”

Section: Discussionmentioning

confidence: 99%

“…3) Isovolumic relaxation time (IVRT) was defined as the temporal interval between T ESV and the onset of rapid LV filling. 4) The LV volume change at 30% and 50% of the diastolic duration (defined as the temporal interval between T ESV to end of the R‐R interval) normalized to stroke volume (SV) was defined as the diastolic index at 30% (DI 30% ) and 50% (DI 50% ), respectively . 5) EFP was defined as the temporal interval between ESV and the onset of atrial contraction (estimated from the dV/dt curve), and the LFP was defined as the interval between the onset and end of atrial contraction.…”

Section: Methodsmentioning

confidence: 99%

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High frame rate cardiac cine MRI for the evaluation of diastolic function and its direct correlation with echocardiography

Zhang

Chen

Cheong

et al. 2019

Magnetic Resonance Imaging

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Background Breath‐hold cine MR is the method of choice for evaluating left ventricular (LV) systolic function; however, the evaluation of diastolic function remains in the domain of high frame rate echocardiography. Thus, a cine MR technique for simultaneously evaluating LV systolic and diastolic function would be clinically valuable. Purpose To test the feasibility of extracting indices that characterize LV diastolic function from high frame rate cine MR. Study Type Single center, prospective. Population Asymptomatic volunteers (N = 24; age 45.8 ± 12.3 years). Field Strength/Sequence High frame rate (70 fps) cine MR and phase‐contrast MR during free breathing were acquired at 1.5T. Assessment The following MR‐based LV filling metrics were extracted from LV volume changes during the cardiac cycle: 1) the volume–rate ratio, REFP/RLFP (ratio of the peak LV filling rate during the early filling period [EFP] to that during the late filling period [LFP]); and 2) the volume ratio, VEFP/VLFP (the ratio of cumulative LV volume change between the EFP and LFP). These metrics were then compared with traditional transmitral blood flow‐based MR and echocardiographic indices. The effect of temporal resolution on these metrics was also evaluated. Statistical Tests Bland–Altman and linear regression analyses were used to evaluate the performance of the proposed metrics against traditional indices of diastolic function. Results The REFP/RLFP and VEFP/VLFP correlated well with E/AQ‐flow (r 2 = 0.66 and 0.54, respectively) and E/Aecho (r 2 = 0.58 and 0.49, respectively). Systolic indices remained robust (<3% error) for frame rates ≥20 fps. Although the proposed VEFP/VLFP was robust (<5% error) up to 25 fps, the proposed volume–rate diastolic function metrics were less reliable (>8% error) for frame rates below 35 fps. Data Conclusion In asymptomatic volunteers, cardiac cine MR images acquired at frame rates >35 fps can be used to extract LV diastolic function indices from the temporal changes in LV volume. Level of Evidence: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1571–1582.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High frame rate cardiac cine MRI for the evaluation of diastolic function and its direct correlation with echocardiography

Zhang

Chen

Cheong

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Other MRI-based diastolic parameters have been proposed, including parameters obtained from flow patterns and tissue characterization (Ellims et al 2012;Okayama et al 2013;T€ oger et al 2016). Atrial tissue characterization has recently become feasible noninvasively using an MRI method for visualizing fibrosis as LA late gadolinium enhancement (LGE) (McGann et al 2008;Gatehouse et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Assessment of diastolic function and atrial remodeling by MRI - validation and correlation with echocardiography and filling pressure

et al. 2018

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Atrial fibrosis can be estimated noninvasively by magnetic resonance imaging (MRI) using late gadolinium enhancement (LGE), but diastolic dysfunction is clinically assessed by transthoracic echocardiography (TTE), and rarely by MRI. This study aimed to evaluate well‐established diastolic parameters using MRI, and validate them with TTE and left ventricular (LV) filling pressures, and to study the relationship between left atrial (LA) remodeling and parameters of diastolic function. The study retrospectively included 105 patients (53 ± 16 years, 39 females) who underwent 3D LGE MRI between 2012 and 2016. Medical charts were reviewed for the echocardiographic diastolic parameters E, A, and e′ by TTE, and pressure catheterizations. E and A were measured from in‐plane phase‐contrast cardiac MRI images, and e′ by feature‐tracking, and validated with TTE. Interobserver and intraobserver variability was examined. Furthermore, LA volumes, function, and atrial LGE was correlated with diastolic parameters. Evaluation of e′ in MRI had strong agreement with TTE (r = 0.75, P < 0.0001), and low interobserver and intraobserver variability. E and A by TTE showed strong agreement to MRI (r = 0.77, P = 0.001; r = 0.73, P = 0.003, for E and A, respectively). Agreement between E/e′ by TTE and MRI was strong (r = 0.85, P = 0.0004), and E/e′ by TTE correlated moderately to invasive pressures (r = 0.59, P = 0.03). There was a strong relationship between LA LGE and pulmonary capillary wedge pressure (r = 0.81, P = 0.01). In conclusion, diastolic parameters can be measured with good reproducibility by cardiovascular MRI. LA LGE exhibited a strong relationship with pulmonary capillary wedge pressure, an indicator of diastolic function.

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“…They demonstrated that this approach allowed a reliable assessment of diastolic function in a mouse model of dilated cardiomyopathy at 4.7 T [47, 147] and the technique was further successfully used by other teams at higher field [1,17,174]. More recently, Buonincontri et al used a similar (simplified) approach derived from echocardiographic color kinesis (Echo-CK), to measure diastolic index in a mouse model of diabetes ([30], at 4.7 T), a concept previously described and validated in humans [113]. Ideally, these measurements require acquisitions with high temporal resolution (C20 phases), to improve their reliability.…”

Section: Evaluation Of Cardiac Volumes Mass and Functionmentioning

confidence: 99%

High field magnetic resonance imaging of rodents in cardiovascular research

et al. 2016

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Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.

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Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study

Cited by 21 publications

References 19 publications

High frame rate cardiac cine MRI for the evaluation of diastolic function and its direct correlation with echocardiography

High frame rate cardiac cine MRI for the evaluation of diastolic function and its direct correlation with echocardiography

Assessment of diastolic function and atrial remodeling by MRI - validation and correlation with echocardiography and filling pressure

High field magnetic resonance imaging of rodents in cardiovascular research

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