Evaluation of Limonoids Against the Murine P388 Lymphocytic Leukemia Cell Line

Abstract

A structure/activity study of selected limonoids from two plant families (Meliaceae and Rutaceae) of the Rutales order against the murine P-388 lymphocytic leukemia system was undertaken. The presence of both a 19 leads to 28 lactol and a 14,15 beta-epoxide group was found especially important for pronounced inhibition of the PS in vitro cell line. Substitution of an A-ring alpha,beta-unsaturated ketone (3-oxo-1-ene) for the lactol led to diminished activity, while reduction of the olefin caused complete loss of activity. At the dose levels employed, even very good PS in vitro inhibition was not translated into PS in vivo antineoplastic effects.

Chemoprotective Effects of Neem Leaf Extract on 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Hamster Buccal Pouch Carcinogenesis.

“…Juss., commonly known as neem, has been traditionally used in India in the treatment of inflammation, viral infection, hypertension, fever, skin disorders, and malignancies [1,2]. The anti-mutagenic and anti-carcinogenic properties of neem preparations have been documented [3][4][5]. In a previous report from this laboratory, we demonstrated the inhibition of 4-nitroquinoline 1-oxide (4NQ0)-induced oral carcinogenesis by neem leaf extract [6].…”

Purification of citrus limonoids and their differential inhibitory effects on human cytochrome P450 enzymes

“…Our recent studies3–9 and many others have demonstrated that limonoids possess numerous health benefits including but not limited to countering the effects of HIV infections,10 antimalarial and anti‐inflammatory activity,11 as well as acting as cytotoxic and cytostatic agents in animals and human cell cultures. The antiproliferative effects of limonoids have been shown in breast cancer,3, 12 colon cancer,4, 13 stomach cancer,14 oral cancer,15 neuroblastoma cancer5, 7 and blood cancer 16. In addition, they have been reported to lower the blood cholesterol17 and act as antioxidants 5, 6, 8.…”

Studies in the Chemical Constituents ofAzadirachta indicaPart II: Isolation and Structure of the New Triterpenoid Azadirachtol

“…Its different parts are highly reputed in folklore and traditional systems of medicine for the treatment of a variety of human ailments, particularly against diseases of bacterial and fungal origin (1,2). More recently the anti-inflammatory, anti-pyretic and anti-tumour, as well as pesticidal activities of its various parts (3)(4)(5)(6) have been reported. We communicated the isolation and structure of nimolicinol from the fruits of this plant (7).…”