Evaluation of Lipid Peroxidation – Antioxidant Protection in Perimenopausal Women with Sleep Disorders

Abstract

Objective: Our aim was to assess lipid peroxidation -antioxidant protection with the definition of the oxidative stress coefficient in perimenopausal women with sleep disorders. Methods: 45 perimenopausal women (mean age 49.1±0.32) were examined: 26 patients with sleep disorders, 19without sleep disorders. Evaluation of sleep disorders was conducted using a questionnaire of Stanford Centre for the Study of Sleep, test for assessment subjective severity of insomnia, the questionnaire for the quantitative assessment of the risks of sleep apnea, the scale for quantifying the degree of daytime sleepiness Epworth. We used spectrophotometric methods for lipid peroxidation -antioxidant system investigation. Statistical analysis was performed by non-parametric tests. Results: In perimenopausal women sleep disorders often presents falling asleep difficulties (93.3%) and morning awakening difficulties (78.8%). Complaints of snoring detected in 33.3% of patients. Insomnia severity index was 21.3±0.54, the total score on the Epworth scale -12.2±0.42. The study results showed increase of secondary products of lipid peroxidation (ketodienes and coupled trienes) levels by 2.2 times (р <0.05). Coefficient oxidative stress in women with sleep disorders is higher by 2 times than in group without sleep disorders. Conclusion: In perimenopausal women sleep disorders are associated with oxidative stress, which is pathogenic rationale for inclusion in the complex therapy of these patients drugs that inhibit of lipid peroxidation activation.

Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause

“…13,159 Recent study identified an evident imbalance between lipid peroxidation (LPO) and the antioxidant defense system among the menopausal insomniacs, 160 providing a pathogenic rationale for including drugs that inhibit LPO activation in the synthetical therapy of these patients. 161 A cross-sectional study involving 187 perimenopausal women also suggested that there was a positive correlation between insomnia score, menopause rating score, and LPO. 157 Acupuncture has been found to normalize disordered LPO processes, and prevent formation and accumulation of LPO products in sleep deprivation-associated regions of the brain, particularly hippocampus.…”