Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin

Abstract

The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.

Hypertension influences the exponential progression of inflammation and oxidative stress in streptozotocin-induced diabetic kidney

“…Further, the serum urea levels were significantly increased after 3 months of diabetes induction, but there is no change in creatinine levels which is in contrast to the previous report where the urea and creatinine levels were found to be higher after 1 month of diabetes induction. [22] These findings confirm the induction of diabetes mellitus in the STZ-induced rats.…”

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

“…In diabetes, reduced body weight is due to loss of proteins and lipid as a result of proteolysis and lipolysis (Hebert & Nair, 2010). The body weight in diabetic rats was significantly decreased compared to normal rat, as shown in previous study (Almeida et al, 2012). The diabetic rat group showed a consistent higher blood glucose level as expected (Cheng et al, 2013), while aqueous extract of H. sabdariffa (HSE) was shown to successfully reduce the blood glucose level significantly probably due to polyphenols are well known as hypoglycaemic agents (Ojulari et al, 2014; Rosemary et al, 2014).…”

Regenerative Potential of D- and #948;-Tocotrienol Rich Fraction on Crushed Skeletal Muscle of Diabetic Rats

“…The result of the present study also indicates that the d-δ-TRF treatment enhances protein synthesis in treated groups and its level is lower in DC, which is in agreement with another study [28] which found that diabetic rats showed lower serum total protein level, and when treated with vitamin E, its level improves significantly.…”