Evaluation of Lipid Profile in Second and Third Trimester of Pregnancy

Abstract

This study helps in understanding baseline lipid parameters in the second and third trimester among pregnant women in India. Total Cholesterol, Triglycerides, LDL-Cholesterol, VLDL-Cholesterol increased in both second and third trimester. The increase is more in third trimester, when compared to second. HDL-Cholesterol is decreased in third trimester when compared to second trimester.

Sex Differences: A Resultant of an Evolutionary Pressure?

“…To adjust to the different needs, lipoprotein profile changes significantly in pregnant women: by week 12 of pregnancy, in response to placental estrogens, HDL cholesterol increases (Ghio et al, 2011). Conversely, total LDL-cholesterol concentrations decrease initially to then increase in the second and third trimester (Montelongo et al, 1992;Pusukuru et al, 2016;Silliman et al, 1994;Stock MJ, 1994). Liver metabolism contributes to the increased energy demand by the placenta and the embryo by enhancing the production of glucose of 16 to 30% (Catalano and Hollenbeck, 1992;Kalhan et al, 1979).…”

Association of tribbles homologue 1 gene expression in human umbilical vein endothelial cells with duration of intrauterine exposure to hyperglycaemia

“…As for the maternal lipid levels, the fact that women from the GDM3 group had lower levels of HDL-C compared to all other studied groups may be a result of a more advanced gestational age at the time of analysis, as HDL-C is known to decrease with progression of pregnancy (Pusukuru et al, 2016). However, we cannot exclude the baseline difference in HDL-C levels because we do not have blood samples collected at the same gestational ages.…”

“…For BP and lipid levels, it should be taken into consideration that they were measured at higher gestational age (after the 34th week) in the GDM3 group. It is known that both parameters normally increase as pregnancy progresses (Pusukuru et al, 2016;Mikami et al, 2017). So, the difference in these parameters could result from different gestational age at the time of their measurement.…”

Association of Thyroid Stimulating Hormone and Lipid Profile in Pregnancy

“…As to how modification in thyroid stimulating hormone modulates changes in lipid profile is yet to be ascertained in an Indian population. The present study is the continuation of the previous study [24] and it aims to determine the association between thyroid stimulating hormone and lipid profile in Indian pregnant women.…”