Evaluation of Liver Function Tests and Serum Bilirubin Levels After Laparoscopic Cholecystectomy

Maleknia, Seyed Adel; Ebrahimi, Niloufar

doi:10.5455/medarh.2020.74.24-27

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…Although the cause of this increase is not fully revealed, it is considered to be multifactorial. These markers may increase in response to the age of the patient, the prevalence of additional diseases, the type of anesthetic drugs used, the length of anesthesia, or a possible bile duct injury [4,10]. Surgery is insufficient to explain the discrepancy in increase observed since the age distribution in both groups in our study is equal (Table 1).…”

Section: Discussionmentioning

confidence: 70%

The Effect of L-Hook Dissection and Scissors Dissection on Liver Injury in Laparoscopic Cholecystectomies

Yıldırım

Özkan

TOPÇU

2021

Cureus

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Purpose: Laparoscopic cholecystectomy is generally performed with the help of monopolar cautery. We aimed to reveal the effect of monopolar cautery use on liver damage in this study.Method: Data of patients who underwent elective cholecystectomy between January 2016 and April 2020 were collected retrospectively. The patients were divided into two groups according to the surgical technique as hook dissection (HD) and scissor dissection (SD). The amount of increase in the preoperative and postoperative alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values of the patients was compared between the two groups.Findings: Over 970 patients were included in the study. The changes in pre-post ALT and AST values were statistically significantly different between the HD (n=469) and SD (n=501) groups (p<0.001; p0.001). 338)) and 444)) changes in the HD method were statistically significantly higher than 371)) and AST (10.8 (−37, 617)) changes in the SD method.Results: ALT and AST values increase after all laparoscopic cholecystectomies. Although the increase in ALT and AST in the HD patients is statistically significant when compared to the SD group, both methods of laparoscopic cholecystectomy can be safely performed because they do not cause permanent liver injury.

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Section: Discussionmentioning

confidence: 70%

The Effect of L-Hook Dissection and Scissors Dissection on Liver Injury in Laparoscopic Cholecystectomies

Yıldırım

Özkan

TOPÇU

2021

Cureus

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“…Therefore, this change could not be an appropriate tool for monitoring iatrogenic bile duct injuries. They followed their patients for 48 hours after surgery, and the final values for AST and ALT were still significantly different from preoperative measurements 59 . This result could be confirmed through a longer follow-up course.…”

Section: Discussionmentioning

confidence: 86%

“…Many reports have shown that the increase in LFTs after uncomplicated LC appears to be a phenomenon without clinical significance since all values return to normal within 72 hours [54][55][56][57][58] . Persisting high values may be seen however, and, if no findings of choledocholithiasis exist, this has been attributed to late common bile duct stricture due to thermal damage 58,59 .…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of three laparoscopic cholecystectomy techniques in rabbit’s model

Wittmaack,

Conceição,

Vera

et al. 2023

Acta Cir. Bras.

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The aim of this randomized study was to compare the complications and perioperative outcome of three different techniques of laparoscopic cholecystectomy (LC). Changes in the liver function test after LC techniques were investigated. Also, we compared the degree of postoperative adhesions and histopathological changes of the liver bed. Methods: Thirty rabbits were divided into three groups: group A) Fundus-first technique by Hook dissecting instrument and Roeder Slipknot applied for cystic duct (CD) ligation; group B) conventional technique by Maryland dissecting forceps and electrothermal bipolar vessel sealing (EBVS) for CD seal; group C) conventional technique by EBVS for gallbladder (GB) dissection and CD seal. Results: Group A presented a longer GB dissection time than groups B and C. GB perforation and bleeding from tissues adjacent to GB were similar among tested groups.Gamma-glutamyl transferase and alkaline phosphatase levels increased (p ≤ 0.05) on day 3 postoperatively in group A. By the 15th postoperative day, the enzymes returned to the preoperative values. Transient elevation of hepatic transaminases occurred after LC in all groups. Group A had a higher adherence score than groups B and C and was associated with the least predictable technique. Conclusion:LC can be performed using different techniques, although the use of EBVS is highly recommended.

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“…Our study observed a case with normal bilirubin returned to abnormal after laparoscopic cholecystectomy. Maleknia and Ebrahimi in 2020, 13 demonstrated significant increases in the bilirubin values. They considered that if no side effects are seen after surgery, this increase appears to be due to the Chen-Wang reported a case of hepatocellular injury where the case clinically was shown an elevation in aminotransferase and bilirubin levels.…”

Section: Resultsmentioning

confidence: 93%

Comparative Study of Liver Function Test in Cholelithiasis Patient Pre and Post Cholecystectomy

Hawar¹,

Lor²

2022

IJDDT

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This study aimed to investigate the changes that occur in liver function tests in cholelithiasis and relate those changes to it. For this purpose, 38 blood specimens were collected from the patients with cholelithiasis undergoing/underwent Cholecystectomy at Azadi-teaching and Kirkuk hospital from January to June 2021, 19 pre-operative samples, and 19 four weeks post-operatively. Our study showed that the gallstone disease was more common in females 17 (89.46%) than males 2 (10.54%). Age was a major risk factor as the patients’ mean age was 39.26 years. Out of 19 patients undergoing cholecystectomy, pre-operative liver function tests (LFT) were normal in 11(61.11%) patients, and abnormal LFT was detected in 8 (44.44 %) patients. Eight (42.1%) patients had elevated alkaline phosphatase (ALK-P levels%), and also had an elevated of AST and ALT. In the serum, slight elevations in the level of total bilirubin 5 (26.3%), and direct bilirubin 3 (15.8) were also noticed in those patients. Following Cholecystectomy (after 4 weeks), in some cases, changes occur in liver function tests where the finding of ALT, AST, and ALK-P closely shows restoration to normal. However, some cases show no significant variation. Statistically, big distinctions between levels of ALK-P, AST, and ALT have been found before and after Cholecystectomy (p is less than 0.0050, p is less than 0.0124, and p is less than 0.0115). The statistical result shows no significance in total bilirubin (TBIL) and direct bilirubin (DBIL) in postoperative cases. At all, there were big distinctions between levels of ALK-P, AST, and ALT before and after Cholecystectomy (p is less than 0.0050, p is less than 0.0124, and p is less than 0.0115, respectively), but levels of total and direct bilirubin revealed no significant distinctions before and after Cholecystectomy.

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Evaluation of Liver Function Tests and Serum Bilirubin Levels After Laparoscopic Cholecystectomy

Cited by 7 publications

References 11 publications

The Effect of L-Hook Dissection and Scissors Dissection on Liver Injury in Laparoscopic Cholecystectomies

The Effect of L-Hook Dissection and Scissors Dissection on Liver Injury in Laparoscopic Cholecystectomies

Comparative evaluation of three laparoscopic cholecystectomy techniques in rabbit’s model

Comparative Study of Liver Function Test in Cholelithiasis Patient Pre and Post Cholecystectomy

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