Evaluation of Local Gum of &lt;i&gt;Acacia polyacantha&lt;/i&gt; as a Suspending Agent in Metronidazole Benzoate Suspension Formulations

Brhane, Yonas; Belete, Anteneh; Gebre‐Mariam, Tsige

doi:10.4314/epj.v30i1.4

Cited by 5 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If it comes out partly, it is considered as having an intermediate viscosity. If, however, the suspensions do not totally come out of the pipette, it is considered as viscous [ 20 ]. As presented in Table 3 , the flow rate decreased with an increase in the concentration of the suspending agent.…”

Section: Resultsmentioning

confidence: 99%

“…To prepare flocculated suspensions, potassium dihydrogen phosphate with a concentration of 0.54% ( w / v ) was used as a flocculating agent. The same step as mentioned above was followed except that the solution of potassium dihydrogen phosphate was added to the smooth paste formed and triturated before the addition of preservative solution [ 20 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the effect of suspending agent concentration on viscosity, the viscosity of all the suspension formulations was measured at room temperature with a viscometer (Brookfield RVDVE-8568340 USA) using spindle number 4 at a shear rate of 20 rpm [ 20 ]).…”

Section: Methodsmentioning

confidence: 99%

“…The sedimentation volumes (%) of the formulations were recorded every day for seven days and then the recording continued every week for a total of four weeks. The readings of the sedimentation volumes (%) were taken where the clear supernatant started to become cloudy upon descending from the top surface of the suspension using the Equation ( 2 ) [ 20 ].

…”

Section: Methodsmentioning

confidence: 99%

“…Hence, the present study is aimed at evaluating the indigenous plant G rewia ferruginea mucilage as an alternative suspending agent in metronidazole benzoate suspension. Metronidazole benzoate is selected as a model drug in this study because it is practically insoluble in water, has a bitter taste, and has poor bioavailability [ 20 ]. Hence, on the basis of its physicochemical properties, it is a good candidate to formulate in suspension dosage form.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension

Haile

Sibhat

Tadese

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Various species of the genus Grewia have been investigated for different pharmaceutical applications as excipients, yet a study on the potential use of Grewia ferruginea mucilage (GFM) as a suspending agent is lacking. Thus, this study is aimed at evaluating the efficacy of Grewia ferruginea mucilage (GFM) as a suspending agent in metronidazole benzoate suspension. The suspensions were prepared using 0.5%, 1%, 1.5%, and 2% w / v of GFM and compared with suspensions prepared from xanthan gum (XGM) and sodium carboxyl methyl cellulose (SCMC) in similar concentrations. The prepared suspensions were evaluated for visual appearance, pH, rheology, sedimentation volume, redispersibility, degree of flocculation, and in vitro drug release profile. Stability study was done at different storage conditions for three months. The results indicated that all the prepared suspension formulations exhibited pseudoplastic flow characteristics with viscosity imparting ability of the suspending agents in the order of XGM > GFM > SCMC ( p < 0.05 ). The flow rate and redispersibility of the formulations prepared with GFM were significantly lower than those with SCMC and higher than those prepared with XGM. At 0.5% w / v suspending agent concentrations, the sedimentation volume of the formulations was in the order of XGM > GFM > SCMC ( p < 0.05 ). However, at all other concentrations, the sedimentation volume of the formulations prepared with GFM had similar results with XGM but exhibited significantly higher sedimentation volume than SCMC. The formulations with GFM showed a higher degree of flocculation at 0.5% w / v concentration but were comparable at 1.5% w / v with XGM containing formulations. The pH, assay, and in vitro release profile of all assessed formulations were within the pharmacopial limit. Thus, based on the finding of this study, it can be concluded that Grewia ferruginea bark mucilage has the potential to be utilized as a suspending agent in suspension formulations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension

Haile

Sibhat

Tadese

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

Plant polysaccharides as suspending agents in pharmaceutical suspensions

Nikazar¹,

Pezeshkpour²,

Bahrololoumi³

2023

Plant Polysaccharides as Pharmaceutical Excipients

View full text Add to dashboard Cite

Physicochemical Characterization and Evaluation of the Binding Effect of Acacia etbaica Schweinf Gum in Granule and Tablet Formulations

Desta

Tadese

Molla

2021

BioMed Research International

View full text Add to dashboard Cite

This study is aimed at evaluating the binding effect of Acacia etbaica gum in granule and tablet formulations using paracetamol as a model drug. Some physicochemical properties of the purified gum such as pH, the presence of tannin and dextrin, solubility, viscosity, loss on drying, total ash value, water solubility index, swelling power, moisture sorption, and powder flow properties were investigated. Paracetamol granules were prepared using wet granulation method at 2%, 4%, 6%, and 8% w / w of the Acacia etbaica gum and compared with granules prepared with reference binders (PVP K-30 and Acacia BP) in similar concentrations. The granules were characterized for bulk and tapped densities, compressibility index and Hausner ratio, angle of repose, flow rate, and friability. Finally, the prepared granules were compressed into tablets and evaluated for different tablet characteristics: weight uniformity, thickness, diameter, crushing strength, tensile strength, friability, disintegration time, and in vitro release profile. The physicochemical characterization revealed that tannins and dextrin are absent in the gum, and the gum has acidic pH. Both the moisture content and total ash values were within the official limits. Furthermore, the gum was found to be soluble in cold and hot water but insoluble in organic solvent and exhibited a shear thickening viscosity profile and excellent flow properties with excellent compressibility. The granules prepared with the gum of Acacia etbaica and reference binders showed good particle size distribution and excellent flow and compressibility properties. All the prepared tablets passed pharmacopeial specifications with respect to their uniformity of weight, thickness, and disintegration time. Tablets formulated with Acacia etbaica gum and acacia BP meet the compendial specification for friability at binder concentrations more than 2%. Drug release properties of all the batches formulated with Acacia etbaica, PVP, and acacia BP complied with the pharmacopeial specification. It can be concluded that the gum of Acacia etbaica could be explored as an alternative excipient for its binder effect in granule and tablet formulations.

show abstract

Evaluation of Local Gum of <i>Acacia polyacantha</i> as a Suspending Agent in Metronidazole Benzoate Suspension Formulations

Cited by 5 publications

References 0 publications

Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension

Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension

Plant polysaccharides as suspending agents in pharmaceutical suspensions

Physicochemical Characterization and Evaluation of the Binding Effect of Acacia etbaica Schweinf Gum in Granule and Tablet Formulations

Contact Info

Product

Resources

About