Evaluation of lozenges containing egg yolk antibody against <i>Porphyromonas gingivalis</i> gingipains as an adjunct to conventional non‐surgical therapy in periodontitis patients: A randomized controlled clinical trial

Nguyen, Sa Van; Nguyen, Minh Tuan; Tran, B.C.; Ho, Minh T.Q.; Umeda, Kouji; Rahman, Sukri

doi:10.1002/jper.18-0037

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Also, treatment with IgY from hens immunized with whole F. nucleatum cells results in a marked decrease in alveolar bone loss after F. nucleatum infection in a mouse model [ 36 ]. A randomized controlled clinical trial of 64 patients with periodontitis showed that the adjunctive use of lozenges containing IgY against P. gingivalis gingipains results in reduction of gingival bleeding index and P. gingivalis cell in gingival pockets [ 37 ]. Further in vivo studies are needed to directly demonstrate the therapeutic effects of our two-in-one IgY.…”

Section: Discussionmentioning

confidence: 99%

Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens

et al. 2020

Journal of Oral Microbiology

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Periodontitis is a bacterial biofilm-induced oral disease, mostly caused by Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ) and Porphyromonas gingivalis ( P. gingivalis ). Oral administration of chicken egg yolk antibody (IgY) is a promising nutritional strategy to control pathogen infections. The objective of this study was to produce an A. actinomycetemcomitans - and P. gingivalis -specific IgY and evaluate its effects on bacterial agglutination and biofilm formation. Thirty laying hens were immunized with a complex of lysate containing typical molecular weights of membrane proteins of A. actinomycetemcomitans and P. gingivalis . IgY was isolated by polyethylene glycol 6000 and ammonium sulfate and purified by dialysis. The results of enzyme-linked immunosorbent assay showed that the obtained IgY were specific to both A. actinomycetemcomitans and P. gingivalis . In addition, immunoelectron microscopy scanning and crystal violet staining showed that the IgY could bind to cell wall of the pathogens and efficiently accelerate agglutination and inhibit biofilm formation. Furthermore, the activity of the IgY remained stable at different temperature, pH, and storage period. This is the first report that a novel two-in-one IgY was produced to modulate the agglutination and biofilm formation of A. actinomycetemcomitans and P. gingivalis , suggesting the potential of IgY to control periodontitis caused by oral pathogens.

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Section: Discussionmentioning

confidence: 99%

Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens

et al. 2020

Journal of Oral Microbiology

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“…Additional clinical studies showing favorable safety of IgY given orally include treatment with a gel containing anti-Candida IgY ( 316 ), treatment with lozenges containing anti- P. gingivalis IgY ( 317 ), ingestion of anti-rotavirus IgY in pediatric patients with rotavirus diarrhea ( 63 , 67 ), and ingesting yogurt containing anti- H. pylori IgY ( 167 ). Parenteral administration of IgY has not been evaluated but may be of value as a single injection in situations such as the need for antivenom treatment.…”

Section: Principles Regarding the Clinical Use Of Igymentioning

confidence: 99%

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

et al. 2021

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Antiviral, antibacterial, and antiparasitic drugs and vaccines are essential to maintaining the health of humans and animals. Yet, their production can be slow and expensive, and efficacy lost once pathogens mount resistance. Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile, primarily in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost. IgY antibodies can readily be generated in large quantities with minimal environmental harm or infrastructure investment by using egg-laying hens. We summarize a variety of IgY uses, focusing on their potential for the detection, prevention, and treatment of human and animal infections.

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“…An interesting option is the adjunctive use of lozenges containing IgY antibody against gingipains from P. gingivalis. It was shown that the use of this therapy resulted in clinical and microbiological benefits in the treatment for chronic periodontitis [252] and may actually also have therapeutic effects in PD.…”

Section: Additional Therapeutic Optionsmentioning

confidence: 99%

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

et al. 2020

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Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially vulnerable. Here, we bring together evidence that the development and presence of PD depends on specific sets of interlinking factors that include neuroinflammation, systemic inflammation, α-Syn-induced cell damage, vascular dysfunction, iron dysregulation, and gut and periodontal dysbiosis. We argue that there is significant evidence that bacterial inflammagens fuel this systemic inflammation, and might be central to the development of PD. We also discuss the processes whereby bacterial inflammagens may be involved in causing nucleation of proteins, including of α-Syn. Lastly, we review evidence that iron chelation, pre-and probiotics, as well as antibiotics and faecal transplant treatment might be valuable treatments in PD. A most important consideration, however, is that these therapeutic options need to be validated and tested in randomized controlled clinical trials. However, targeting underlying mechanisms of PD, including gut dysbiosis and iron toxicity, have potentially opened up possibilities of a wide variety of novel treatments, which may relieve the characteristic motor and nonmotor deficits of PD, and may even slow the progression and/or accompanying gut-related conditions of the disease.

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Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non‐surgical therapy in periodontitis patients: A randomized controlled clinical trial

Cited by 11 publications

References 18 publications

Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens

Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

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