Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes

Erol, Seyit Ahmet; Tanaçan, Atakan; Anuk, Ali Taner; Tokalıoğlu, Eda Özden; Biriken, Derya; Keskin, Hüseyin Levent; Moraloğlu, Özlem; Yazıhan, Nuray; Şahın, Dilek

doi:10.1002/jmv.26725

Cited by 38 publications

(32 citation statements)

References 43 publications

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“…Obstetrical complications associate with infection generally [99]. Some complications may depend on the nature of the symptomatic and asymptomatic state [56].…”

Section: Nature Of Diseasementioning

confidence: 99%

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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“…Obstetrical complications associate with infection generally [99]. Some complications may depend on the nature of the symptomatic and asymptomatic state [56].…”

Section: Nature Of Diseasementioning

confidence: 99%

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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“…These findings suggest that plasma/serum AFM concentrations have the potential to serve as predictive markers for various medical conditions. However, AFM and α-Toc concentrations are significantly correlated in follicular and cerebrospinal fluids, but not in plasma or serum [81,85,86]. The expression of AFM has also been confirmed in other organs such as the human kidney [83], and Kratzer et al [87] reported that AFM is synthesised by brain capillary endothelial cells and mediates α-Toc transport into the central nervous system across the blood-brain barrier.…”

Section: Afaminmentioning

confidence: 99%

The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows

Haga

Ishizaki

Roh

2021

Animals

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Levels of alpha-tocopherol (α-Toc) decline gradually in blood throughout prepartum, reaching lowest levels (hypovitaminosis E) around calving. Despite numerous reports about the disease risk in hypovitaminosis E and the effect of α-Toc supplementation on the health of transition dairy cows, its risk and supplemental effects are controversial. Here, we present some novel data about the disease risk of hypovitaminosis E and the effects of α-Toc supplementation in transition dairy cows. These data strongly demonstrate that hypovitaminosis E is a risk factor for the occurrence of peripartum disease. Furthermore, a study on the effectiveness of using serum vitamin levels as biomarkers to predict disease in dairy cows was reported, and a rapid field test for measuring vitamin levels was developed. By contrast, evidence for how hypovitaminosis E occurred during the transition period was scarce until the 2010s. Pioneering studies conducted with humans and rodents have identified and characterised some α-Toc-related proteins, molecular players involved in α-Toc regulation followed by a study in ruminants from the 2010s. Based on recent literature, the six physiological factors: (1) the decline in α-Toc intake from the close-up period; (2) changes in the digestive and absorptive functions of α-Toc; (3) the decline in plasma high-density lipoprotein as an α-Toc carrier; (4) increasing oxidative stress and consumption of α-Toc; (5) decreasing hepatic α-Toc transfer to circulation; and (6) increasing mammary α-Toc transfer from blood to colostrum, may be involved in α-Toc deficiency during the transition period. However, the mechanisms and pathways are poorly understood, and further studies are needed to understand the physiological role of α-Toc-related molecules in cattle. Understanding the molecular mechanisms underlying hypovitaminosis E will contribute to the prevention of peripartum disease and high performance in dairy cows.

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“…Les caractéristiques des études incluses sont résumées à l'annexe 3, accessible en anglais au www.cmaj.ca/lookup/ doi/10.1503/cmaj.202604/tab-related-content. Sur les 42 études, 16 portaient sur des cohortes prospectives 7,9,11,18,19,21,28,30,33,34,36,37,46,[49][50][51] , 21, sur des cohortes rétrospectives 8,10,12-14,17,27,29,32,35,38-45,48,53,54 et 5, sur des études cas-témoins 22,31,47,50,52 . Une étude prospective a donné lieu à 2 publications, soit une étude en prépublication portant sur un résultat positif à l'infection par rapport à un résultat négatif au dépistage du SRAS-CoV-2 34 , et une autre portant sur une infection grave comparée à une infection légère par la COVID-19 18 .…”

Section: Résultatsunclassified

“…Les cas de COVID-19 ont été confirmés par un test de dépistage par PCR. Vingt-huit études portaient sur une infection par le SRAS-CoV-2 confirmée durant la grossesse comparativement à l'absence d'infection [11][12][13]15,22,[27][28][29][30][31][32]34,35,37,[39][40][41][42][43][44][45][47][48][49][50][51]53,54 . Douze études ont mis en parallèle la COVID-19 symptomatique et asymptomatique [7][8][9][10][11][12][13][14][15]46,48,52 .…”

Section: Résultatsunclassified

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Incidence de la COVID-19 sur les issues de grossesse: examen systématique et méta-analyse

Wei

Bilodeau-Bertrand

Liu

et al. 2021

CMAJ

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a maladie à coronavirus 2019 , causée par le coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2), a fait l'objet d'une déclaration de pandémie en mars 2020 1 . Les personnes enceintes et les nourrissons pourraient être particulièrement susceptibles de contracter la COVID-19, car la grossesse induit des changements physiologiques touchant l'appareil cardiorespiratoire et le système immunitaire, ce qui pourrait altérer la réponse à l'infection par le SRAS-CoV-2 2 . Par ailleurs, le foetus peut être exposé au SRAS-CoV-2 pendant une période critique de son développement 3 . La nature de l'association entre la COVID-19 et les issues de grossesse reste mal définie, et les méta-analyses portant sur des patientes enceintes atteintes de la COVID-19 ont une portée limitée. Quant aux revues publiées, elles se concentrent principalement sur des estimations de prévalence tirées d'études de cas ou de séries de cas difficiles à interpréter et potentiellement biaisées 4,5 . Selon une revue systématique publiée en 2020, les personnes enceintes ne présentaient pas un risque supérieur d'infection par le SRAS-CoV-2 ou de COVID-19 symptomatique, mais elles étaient exposées à un risque accru de COVID-19 grave par rapport à celles qui n'étaient pas enceintes 5 . Notons toutefois que cette revue incluait des cas probables de COVID-19 en plus des RECHERCHE Incidence de la COVID-19 sur les issues de grossesse : examen systématique et méta-analyse

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Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes

Cited by 38 publications

References 43 publications

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows

Incidence de la COVID-19 sur les issues de grossesse: examen systématique et méta-analyse

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