Evaluation of matrix metalloproteinase-9 plasma levels in untreated new Relapsing–remitting multiple sclerosis patients and their first-degree family

Samangooei, Mahsa; Farjam, Mojtaba; Niknam, Zahra; Etemadifar, Masoud; Meshkibaf, Mohammad Hasan; Noroozi, Saam

doi:10.1007/s11011-021-00758-9

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…Both in treatment-naive RRMS patients and in the kin of the first degree of MS patients (high risk subjects), the plasma MMP-9 level was higher in women (p = 0.011). A decrease in the plasma MMP-9 level with age was also observed, both in treatment-naive RRMS patients and in subjects from the high risk group (p = 0.001 and p = 0.025, respectively) (Samangooei et al, 2021). This research group strongly recommends the use of MMP-9 as a biomarker in MS pathogenesis (Samangooei et al, 2021).…”

Section: Multiple Sclerosismentioning

confidence: 95%

“…A decrease in the plasma MMP-9 level with age was also observed, both in treatment-naive RRMS patients and in subjects from the high risk group (p = 0.001 and p = 0.025, respectively) (Samangooei et al, 2021). This research group strongly recommends the use of MMP-9 as a biomarker in MS pathogenesis (Samangooei et al, 2021).…”

Section: Multiple Sclerosismentioning

confidence: 95%

“…That relationship was not confirmed by studies of Valado et al (2017) , but they found that in the control group (healthy subjects), the presence of the T allele was associated with higher plasma MMP-9 levels ( p = 0.008). The latest study showed that plasma MMP-9 levels were higher in treatment-naive patients with relapsing–remitting multiple sclerosis (RRMS) when compared to healthy subjects ( Samangooei et al, 2021 ). Furthermore, plasma MMP-9 levels in the kin of the first degree of MS patients (high risk subjects) were higher than in the control group, but this result was not statistically significant ( p = 0.208) ( Samangooei et al, 2021 ).…”

Section: Brain Disorders Associated With the Mmp-9-1562c/t Polymorphismmentioning

confidence: 99%

“…The latest study showed that plasma MMP-9 levels were higher in treatment-naive patients with relapsing–remitting multiple sclerosis (RRMS) when compared to healthy subjects ( Samangooei et al, 2021 ). Furthermore, plasma MMP-9 levels in the kin of the first degree of MS patients (high risk subjects) were higher than in the control group, but this result was not statistically significant ( p = 0.208) ( Samangooei et al, 2021 ). Both in treatment-naive RRMS patients and in the kin of the first degree of MS patients (high risk subjects), the plasma MMP-9 level was higher in women ( p = 0.011).…”

Section: Brain Disorders Associated With the Mmp-9-1562c/t Polymorphismmentioning

confidence: 99%

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Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Pabian‐Jewuła

Rylski

2023

Front. Cell. Neurosci.

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Metalloproteinase-9 (MMP-9) is one of the most strongly expressed matrix metalloproteinases (MMPs) in the brain. The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barré syndrome. This article discusses a relationship between development of the nervous system diseases and the functional single nucleotide polymorphism (SNP) at position -1562C/T within the MMP-9 gene. A pathogenic influence of MMP-9-1562C/T SNP was observed both in neurological and psychiatric disorders. The presence of the allele T often increases the activity of the MMP-9 gene promoter and consequently the expression of MMP-9 when compared to the allele C. This leads to a change in the likelihood of an occurrence of diseases and modifies the course of certain brain diseases in humans, as discussed below. The presented data indicates that the MMP-9-1562C/T functional polymorphism influences the course of many neuropsychiatric disorders in humans suggesting a significant pathological role of the MMP-9 metalloproteinase in pathologies of the human central nervous system.

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Section: Multiple Sclerosismentioning

confidence: 95%

Section: Multiple Sclerosismentioning

confidence: 95%