The study is devoted to the Unsteady Reynolds-Averaged Navies-Stokes (URANS) simulation of ventilation in an isothermal room with numerous jets supplied from ceiling diffusers. The computations of the airflow under the test conditions considered were carried out in the classroom of the Technical University of Sofia with no occupants. The room floor has a simple rectangular form, but several columns, beams, window sills, and four radiators are located inside the room that makes the geometry more complex. Air is supplied to the room through four ceiling fan coils, the Reynolds number is 2×104. Calculations were carried out using the ANSYS Fluent 18.2 software with the standard k-ε turbulence model chosen. Computational meshes of up to 33 million hexahedral cells clustered to the inlet and outlet sections were used. The main aim of the study presented is to analyze and discuss the complicated 3D flow structure in the room and to give foundation for future measurements of air velocity field in the room.