Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Cevher, Erdal; Taha, M. A.; Orlu, Mine; Araman, Ahmet

doi:10.1080/10717540701829234

Cited by 95 publications

(89 citation statements)

References 43 publications

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“…33) Cevher et al showed that the hardness value less than 396 mN was found to be suitable for the application onto mucosal ephitelium. 32) Similar results were obtained in our study and it was determined that the hardness of prepared gels were in the acceptable range based on previous studies. 31,32) The cohesiveness is important to determine the reconstruction ability of the gel after application.…”

Section: Resultssupporting

confidence: 91%

“…32) Similar results were obtained in our study and it was determined that the hardness of prepared gels were in the acceptable range based on previous studies. 31,32) The cohesiveness is important to determine the reconstruction ability of the gel after application. 34,35) The high cohesiveness value increases the performance of the product at the application site by providing full structural recovery following gel application.…”

Section: Resultssupporting

confidence: 91%

“…34,35) The high cohesiveness value increases the performance of the product at the application site by providing full structural recovery following gel application. 15,32) In this study, the cohesiveness (A1: 0.960Ϯ0.011; A3: 1.096Ϯ0.014) increased upon increasing the chitosan concentration (pϽ0.05) (Fig. 2).…”

Section: Resultsmentioning

confidence: 53%

“…13) In this study, the mechanical properties such as hardness, cohesiveness and adhesiveness of gel formulations were investigated using texture profile analysis. 15,[30][31][32] The hardness test was performed to measure the required force to produce deformation of hydrogels. Low gel hardness ensures that the minimum work is required for removal of gels from the container and the applicability onto the desired site.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, value decreases the retention time of gel formulation on the wound and therefore, a hydrogel formulation should have an appropriate hardness value for the effective treatment of wounds. 31,32) It was reported that the hardness of gel formulations were significantly affected by the molecular weight and concentration of the polymer. 15) Tan et al showed that the gel hardness was dependent on the concentrations of hydroxyethylcellulose, polyvinyl pyrrolidone and polycarbophil in formulations.…”

Section: Resultsmentioning

confidence: 99%

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Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Sezer

Cevher

Hatıpoğlu

et al. 2008

Biological & Pharmaceutical Bulletin

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161

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Burn healing includes a specific biological process related to the general phenomenon of growth and regeneration and the primary objective in burn care is the promotion of rapid wound healing with the best functional results. The principal function of a burn dressing is to provide an optimum healing milieu for natural healing and desirable burn dressing may, therefore, be characterized on the basis of its performance such as; (a) provision of adequate gaseous exchange, (b) provision and maintenance of a moist environment, (c) protection from infections and contamination, (d) absorption of wound fluids and (e) painless and easy removal. 1,2) Hydrogels are ideal biopolymeric pharmaceutical forms for the treatment of skin wounds. They have low interfacial tension, high molecular and oxygen permeability, good moisturizing and mechanical properties that resemble physiological soft tissue. 3,4) For this reasons, polysaccharides, e.g. chitosan, are having hydrogel forming properties have been considered to be advantageous in its application as a wound dressing material. 5) Chitosan, [a (1→4) 2-amino-2-deoxy-b-D-glucan], a unique polysaccharide derived from deacetylation of chitin, has been used in wound treatment owing to its good biocompatibility, biodegradability and accelerated granulation. [6][7][8] On the other hand, fucoidan is a sulphated polyfucose polysaccharide and has attracted considerable biotechnological research interest since the discovery that it possessed anti-coagulant activity similar to that of heparin and also reported to possess other properties including antithrombotic, anti-inflammatory, anti-tumoral and anti-viral effects. 9,10) Many of these effects are thought to be due to its interaction with growth factors such as basic fibroblast growth factor (bFGF) and transforming growth factor-b (TGF-b). Fucoidan may, therefore, be able to modulate growth factordependent pathways in the cell biology of tissue repair. 11) Although a great number of studies on different pharmacological properties of fucoidan and chitosan are present, there is little information on the fucoidan-based system used in burn healing and its only limited with cell culture. 12) The aim of this study was to prepare fucoidan-chitosan hydrogel and to investigate its treatment efficiency on dermal burns on rabbits. MATERIALS AND METHODSMaterials Chitosan (MW 250 kDa, deacetylation degree Ն90%, Pronova A/S, Norway; MW 400 kDa, deacetylation degree Ն60%, Fluka, Germany; MW 750 kDa, deacetylation degree Ն75%, Sigma, U.S.A.), Fucoidan (from Fucus vesiculosus) and lactic acid (85% m/v) purchased from Sigma, U.S.A. All other reagents used were of analytical grade.Preparation of Hydrogels The composition of gel formulations was given in Table 1. Fucoidan was dissolved in 1% m/v lactic acid solution by mechanical shaking at 300 rpm for 1 h. Then chitosan was left to swell in the fucoidan solution overnight to prepare hydrogels. 13) Formulations were kept at 4°C until experiment.Viscosity Measurement The viscosity of hydrogels was determine...

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Sezer

Cevher

Hatıpoğlu

et al. 2008

Biological & Pharmaceutical Bulletin

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161

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Bioadhesive Polymers for Drug Delivery

Larrañeta

Donnelly

2017

Polymers for Biomedicine

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Improved texture analysis for hydrogel characterization: Gel cohesiveness, adhesiveness, and hardness

Hurler

Engesland

Kermany

et al. 2011

J of Applied Polymer Sci

218

117

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The texture properties of formulation are an important parameter in optimization of topical formulations. These properties will affect applicability of the formulation at the administration site and therapy outcome. Our aim was to develop a fast and reliable method to characterize texture properties of hydrogels, namely cohesiveness, adhesiveness, and hardness. During the method development, we realized that the measurements setup needed to be adjusted for each hydrogel type, namely Carbopol, chitosan, and poloxamer hydrogels. The influence of the polymer concentration, pH, and incorporation of additives such as glycerol, drug solution, or liposomes on the texture properties, as determined by Texture Analyzer, was evaluated. In addition, the new method was applied to determine the changes during the accelerated stability testing. While Carbopol and poloxamer gels showed a linear relationship between the polymer concentration and texture properties, for low molecular weight chitosan gels the properties increased in exponential manner with increasing polymer concentration. The effect of incorporated liposomes on the gel properties was found to be dependent on the type of hydrogel. The hydrogel hardness was affected by the temperature as seen in accelerated stability testing. The method represents a valuable tool in pharmaceutical and cosmetics formulation development. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Cited by 95 publications

References 43 publications

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Bioadhesive Polymers for Drug Delivery

Improved texture analysis for hydrogel characterization: Gel cohesiveness, adhesiveness, and hardness

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