EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

Abstract

The incidence of bronchopulmonary dysplasia (BPD) and neuro-developmental sequelae in 135 infants surviving intermittent positive pressure ventilation (IPPV) in the newborn period were studied in relation to primary disorders requiring IPPV. The rate of BPD increased over the 6-year study period in hyaline membrane disease survivors from 14% to 28%, but decreased in infants with apnoea repetens from 38% to 13%. Immaturity seemed to be one important factor for development of BPD. The incidence of neuro-developmental sequelae in IPPV treated infants fell from 22% to 13% over the years. In infants with birth weight below 1501 g the rate of neurological handicaps was 11%.

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: I. Techniques and survival rates

“…Such an approach is not only immediately rewarding but is also a prerequisite of further progress. The low incidence of late sequelae in this material (9) further supports an active attitude to the management of VLBW infants.…”

Pulmonary Mechanics, Chest X‐ray and Lung Disease After Mechanical Ventilation in Low Birth Weight Infants

“…Improved intensive care including assisted ventilation have resulted in increasing survival rates even for the smallest infants (17,19,27,30,33,38). In our clinic the use of early CPAP via the face chamber technique (3) has restrict-ed the need for IPPV at HMD to the most immature infants and those arriving in a bad condition (20,36). In AR, IPPV has to a great extent been replaced by other therapeutic measures such as low-pressure CPAP, refined adjustment of inspired oxygen and theophyllamine administration (20).…”

Abstract

“…Results from the N.I.C.U. in Lund, Sweden (43)(44)(45)(46)(47)(48)(49), are as good as those of major centers in Canada.…”