Evaluation of meso-substituted cationic corroles as potential antibacterial agents

Cardote, Teresa A.F.; Barata, Joana F. B.; Amador, Carolina; Alves, Eliana; Neves, Maria G. P. M. S.; Cavaleiro, José A. S.; Almeida, Adelaide; Faustino, Maria A. F.

doi:10.1590/0001-3765201820170824

Cited by 20 publications

(13 citation statements)

References 56 publications

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“…In fact, many efforts have been devoted to the synthesis of corroles in recent years [ 4 , 5 , 6 , 7 ]. Their free-bases and metal complexes have been explored in a wide range of applications [ 8 , 9 ], namely as promising drug candidates for prevention and treatment of diverse diseases, such as diabetes, neurodegenerative diseases and cancer [ 10 , 11 , 12 , 13 , 14 ], as antibacterial agents [ 15 ] as well as bio-imaging agents [ 16 ]. Corroles also found application in the photodynamic inactivation of microorganisms (PDI) [ 17 ], sonodynamic therapy [ 18 ] and photodynamic therapy (PDT) [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Corroles and Hexaphyrins: Synthesis and Application in Cancer Photodynamic Therapy

2020

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Corroles and hexaphyrins are porphyrinoids with great potential for diverse applications. Like porphyrins, many of their applications are based on their unique capability to interact with light, i.e., based on their photophysical properties. Corroles have intense absorptions in the low-energy region of the uv-vis, while hexaphyrins have the capability to absorb light in the near-infrared (NIR) region, presenting photophysical features which are complementary to those of porphyrins. Despite the increasing interest in corroles and hexaphyrins in recent years, the full potential of both classes of compounds, regarding biological applications, has been hampered by their challenging synthesis. Herein, recent developments in the synthesis of corroles and hexaphyrins are reviewed, highlighting their potential application in photodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

Corroles and Hexaphyrins: Synthesis and Application in Cancer Photodynamic Therapy

2020

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“…Most of the success behind this approach is associated with the availability of photosensitizers with adequate structural features. In this regard, porphyrins are recognized as an essential class of derivatives to be associated with PDT and aPDT applications, since their action can be triggered under visible light [3,4,5,6,7,8,9,10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

New Materials Based on Cationic Porphyrins Conjugated to Chitosan or Titanium Dioxide: Synthesis, Characterization and Antimicrobial Efficacy

Castro

Moura

Figueira

et al. 2019

IJMS

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The post-functionalization of 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide, known as a highly efficient photosensitizer (PS) for antimicrobial photodynamic therapy (aPDT), in the presence of 3- or 4-mercaptobenzoic acid, afforded two new tricationic porphyrins with adequate carboxylic pending groups to be immobilized on chitosan or titanium oxide. The structural characterization of the newly obtained materials confirmed the success of the porphyrin immobilization on the solid supports. The photophysical properties and the antimicrobial photodynamic efficacy of the non-immobilized porphyrins and of the new conjugates were evaluated. The results showed that the position of the carboxyl group in the mercapto units or the absence of these substituents in the porphyrin core could modulate the action of the photosensitizer towards the bioluminescent Gram-negative Escherichia coli bacterium. The antimicrobial activity was also influenced by the interaction between the photosensitizer and the type of support (chitosan or titanium dioxide). The new cationic porphyrins and some of the materials were shown to be very stable in PBS and effective in the photoinactivation of E. coli bacterium. The physicochemical properties of TiO2 allowed the interaction of the PS with its surface, increasing the absorption profile of TiO2, which enables the use of visible light, inactivating the bacteria more efficiently than the corresponding PS immobilized on chitosan.

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“…[213][214][215] Some cationic gallium corroles bearing ortho or para-methylpyridinium moieties have been prepared (Fig. 85) 216 and their antibacterial activities against the Gram-negative bacterium A. fischeri were evaluated and compared to TMPyP4, a well-known reference in biological studies. Fig.…”

Section: Antibacterial Activities and Photodynamic Inactivation (Pdi)mentioning

confidence: 99%

“…85 Cationic gallium corroles bearing ortho-or para-methylpyridinium moieties. 216 Fig. 86 Corrole-grafted-chitosan films.…”

Section: Photodynamic Therapy (Pdt) Applicationsmentioning

confidence: 99%

Corroles at work: a small macrocycle for great applications

2022

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Evaluation of meso-substituted cationic corroles as potential antibacterial agents

Cited by 20 publications

References 56 publications

Corroles and Hexaphyrins: Synthesis and Application in Cancer Photodynamic Therapy

Corroles and Hexaphyrins: Synthesis and Application in Cancer Photodynamic Therapy

New Materials Based on Cationic Porphyrins Conjugated to Chitosan or Titanium Dioxide: Synthesis, Characterization and Antimicrobial Efficacy

Corroles at work: a small macrocycle for great applications

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