Corroles at work: a small macrocycle for great applications

Abstract

The review summarizes the exploitations of corrole derivatives in many different fields, where the peculiar properties of these contracted macrocycles lead to the development of promising applications.

Phosphorous (V) Corrole Fluorophores for Nitrite Assessment in Environmental and Biological Samples

“…This structural modification is expected to generate a shift of electron density around the peripheral area of the macrocycle leading to the promoted anionic sensitivity. The luminescence quantum yields, Φ F , were estimated for both fluorophores in CHCl 3 according to the common procedure [22], and were 0.22 and 0.26 for PCorr and PFCorr, respectively.…”

“…Chemosensors 2022, 10, x 6 of 12 macrocycle leading to the promoted anionic sensitivity. The luminescence quantum yields, ΦF, were estimated for both fluorophores in CHCl3 according to the common procedure [22], and were 0.22 and 0.26 for PCorr and PFCorr, respectively. PFCorr showed a great fluorescence emission property in the region 550-680 nm upon the excitation at 413 nm, corresponding to the ligand Soret band absorbance maximum.…”

“…The accurate selection of the appropriate macromolecular ligands selectively binding to the target analyte has permitted the development of selective optodes for several inorganic anions, including nitrites [17][18][19][20]. Among these ligands (or ionophores) metalloporphyrin and metallocorrole complexes are particularly suitable for anion sensing through metal-anion coordination, a type of Lewis acid-base interaction [21,22]. The metallocorroles have significant potential to be integrated in optical sensors, a sensor type that has seen many technological developments and applications, including in a wide variety of smartphones [23,24].…”

Can Corrole Dimers Be Good Photosensitizers to Kill Bacteria?

“…Corroles are aromatic contracted tetrapyrrolic macrocycles with unique physicochemical features to be used in different fields including oxidative catalysis, sensing, and therapeutic applications [1][2][3][4][5]. Under the context of medicinal applications, their optical properties such as high extinction molar coefficients, fluorescence quantum yield (Φ Flu ), and ability to generate singlet oxygen ( 1 O 2 ) make them obvious candidates to be exploited as therapeutic agents, namely for photodynamic therapy (PDT) for cancer [5][6][7][8][9][10][11][12][13][14] and antimicrobial photodynamic therapy (aPDT) approaches [15,16].…”

“…Under the context of medicinal applications, their optical properties such as high extinction molar coefficients, fluorescence quantum yield (Φ Flu ), and ability to generate singlet oxygen ( 1 O 2 ) make them obvious candidates to be exploited as therapeutic agents, namely for photodynamic therapy (PDT) for cancer [5][6][7][8][9][10][11][12][13][14] and antimicrobial photodynamic therapy (aPDT) approaches [15,16]. The principles of PDT for treating cancer cells and aPDT for eliminating microorganisms are the same; both approaches require the activation of a dye (the photosensitizer, PS) by an adequate visible light source in the presence of dioxygen ( 3 O 2 ) in order to produce reactive oxygen species (ROS, e.g., 1 O 2 , among others) responsible for selective killing. Recent developments show that aPDT can be considered a promising alternative to antibiotics in order to deal with the emerging public health problem associated with the growing rate of resistant bacteria strains [17][18][19].…”