Evaluation of mitochondrial respiratory chain activity in muscle healing by low-level laser therapy

Silveira, Paulo Cesar; Silva, Luciano Acordi da; Fraga, Daiane B.; Freitas, Tiago P.; Streck, Emílio L.; Pinho, Ricardo A.

doi:10.1016/j.jphotobiol.2009.01.004

Cited by 176 publications

(136 citation statements)

References 24 publications

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“…Commonly used modalities to help recovery, such as mas- ous studies have also demonstrated that LLLT can stimulate the mitochondrial respiratory chain and ATP synthesis. 20,29 Such effects could, in turn, contribute to a decrease in CK activity, CRP levels, and also the delay in development of fatigue seen in the current study. Some evidence suggests that other therapies such as massage 39 and hot-cold water baths 15 may prevent muscle damage after exercise.…”

Section: Discussionmentioning

confidence: 69%

“…6 Studies performed in animals have shown positive effects of LLLT in the form of inflammatory reduction and improvement in muscle repair when the optimal parameters of irradiation were used. 1,8,24,31 Studies into the mechanisms behind these effects suggest that LLLT can decrease oxidative stress and reactive oxygen species production, 2,27 improve mitochondrial function, 37 and stimulate mitochondrial respiratory chain, ATP synthesis, 29 and microcirculation. 34 These effects provides the rationale for testing if LLLT can prevent the development of skeletal muscle fatigue and enhance recovery.…”

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confidence: 99%

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Effects of Low-Level Laser Therapy (LLLT) in the Development of Exercise-Induced Skeletal Muscle Fatigue and Changes in Biochemical Markers Related to Postexercise Recovery

Leal-Junior¹,

Lopes-Martins²,

Frigo³

et al. 2010

Journal of Orthopaedic & Sports Physical Therapy

174

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investigating the effects of commonly used interventions, such as massage, lowintensity exercises, cryotherapy, hot-cold contrast baths, neuro-muscular electrical stimulation, and stretching, are few, and the results on effectiveness are mixed. 3 The rationale behind the use of these interventions is often related to mechanisms such as reducing postexercise inflammatory responses and the promotion of circulation and local metabolism t BacKgRound: Cell and animal studies have suggested that LLLT can reduce oxidative stress and inflammatory responses in muscle tissue. But it remains uncertain whether these findings can translate into humans in sport and exercise situations.t Methods: Nine healthy male volleyball players participated in the study. They received either active LLLT (cluster probe with 5 laser diodes; λ = 810 nm; 200 mW power output; 30 seconds of irradiation, applied in 2 locations over the biceps of the nondominant arm; 60 J of total energy) or placebo LLLT using an identical cluster probe. The intervention or placebo were applied 3 minutes before the performance of exercise. All subjects performed voluntary elbow flexion repetitions with a workload of 75% of their maximal voluntary contraction force until exhaustion.t Results: Active LLLT increased the number of repetitions by 14.5% (mean  SD, 39.6  4.3 versus 34.6  5.6; P = .037) and the elapsed time before exhaustion by 8.0% (P = .034), when compared to the placebo treatment. The biochemical markers also indicated that recovery may be positively affected by LLLT, as indicated by postexercise blood lactate levels (P.01), creatine kinase activity (P = .017), and C-reactive protein levels (P = .047), showing a faster recovery with LLLT application prior to the exercise. t conclusion: We conclude that pre-exercise irradiation of the biceps with an LLLT dose of 6 J per application location, applied in 2 locations, increased endurance for repeated elbow flexion against resistance and decreased postexercise levels of blood lactate, creatine kinase, and Creactive protein.t level oF evidence: Performance enhancement, level 1b.

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Section: Discussionmentioning

confidence: 69%

mentioning

confidence: 99%

Effects of Low-Level Laser Therapy (LLLT) in the Development of Exercise-Induced Skeletal Muscle Fatigue and Changes in Biochemical Markers Related to Postexercise Recovery

Leal-Junior¹,

Lopes-Martins²,

Frigo³

et al. 2010

Journal of Orthopaedic & Sports Physical Therapy

174

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“…Due to the proven ability of red-infrared (IR) radiation to enhance cell energy metabolism (Silveira et al 2009) and reduce inflammation (Rizzi et al 2006), laser therapy is already used in physical medicine, rehabilitation and sports medicine to accelerate muscle recovery (dos Santos et al 2010) and to prevent damages produced by metabolic disturbances and inflammatory reactions after heavy exercise (Leal Junior et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Effect of IR Laser on Myoblasts: Prospects of Application for Counteracting Microgravity-Induced Muscle Atrophy

Monici

Cialdai

Romano

et al. 2012

Microgravity Sci. Technol.

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Microgravity-induced muscle atrophy is a problem of utmost importance for the impact it may have on the health and performance of astronauts. Therefore, appropriate countermeasures are needed to prevent disuse atrophy and favour muscle recovery. Muscle atrophy is characterized by loss of muscle mass and strength, and a shift in substrate utilization from fat to glucose, that leads to a reduced metabolic efficiency and enhanced fatigability. Laser therapy is already used in physical medicine and rehabilitation to accelerate muscle recovery and in sports medicine to prevent damages produced by metabolic disturbances and inflammatory reactions after heavy exercise. The aim of the research we present was to get insights on possible benefits deriving from the application of an advanced infrared laser system to counteract deficits of muscle energy metabolism and stimulate the recovery of the hypotrophic tissue. The source used was a Multiwave Locked System (MLS) laser, which combines continuous and pulsed emissions at 808 nm and 905 nm, respectively. We studied the effect of MLS treatment on morphology and energy metabolism of C2C12 cells, a widely accepted myoblast model, previously exposed to microgravity conditions modelled by a Random Positioning Machine. The MLS laser treatment was able to restore basal levels of serine/threonine protein phosphatase activity and to counteract cytoskeletal alterations and increase in glycolytic enzymes activity that occurred following the exposure to modelled microgravity. In conclusion, the results provide interesting insights for the application of infrared laser in the treatment of muscle atrophy.

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“…De fato, a literatura mostra que a LLLT (AsGa; λ 904nm; 5J/cm 2 ) aumentou significativamente a atividade de succinato desidrogenase mitocondrial em músculo esquelético após injúria, além de ter influenciado positivamente também os complexos I, II, III e IV da cadeia respiratória (261) .…”

Section: Discussionunclassified

“…Isto porque um aumento da atividade das mitocôndrias leva à consequente geração de ATP e aceleração do metabolismo celular (261) , tornando-se importante para a reparação tecidual frente a injúrias, por exemplo (268)(269)(270) .…”

Section: Discussionunclassified

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

Sperandio¹

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Evaluation of mitochondrial respiratory chain activity in muscle healing by low-level laser therapy

Abstract: These results suggest that the treatment with low-level laser may induce an increase in ATP synthesis, and that this may accelerate the muscle healing process.

Cited by 176 publications

References 24 publications

Effects of Low-Level Laser Therapy (LLLT) in the Development of Exercise-Induced Skeletal Muscle Fatigue and Changes in Biochemical Markers Related to Postexercise Recovery

Effects of Low-Level Laser Therapy (LLLT) in the Development of Exercise-Induced Skeletal Muscle Fatigue and Changes in Biochemical Markers Related to Postexercise Recovery

Effect of IR Laser on Myoblasts: Prospects of Application for Counteracting Microgravity-Induced Muscle Atrophy

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

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