Evaluation of moldable, <i>in situ</i> hardening calcium phosphate bone graft substitutes

Schmidlin, Patrick R.; Nicholls, Flora; Kruse, Astrid L; Zwahlen, Roger A.; Weber, Franz E.

doi:10.1111/j.1600-0501.2011.02315.x

Cited by 55 publications

(70 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, 21.34 ± 9.14% of the grafted area was occupied by newly formed vital bone (Table 1). Similar levels of new bone formation have been reported in rabbit calvaria defects model published by Schmidlin et al [28] using the same material and revealing 20.16 ± 5.27% of new bone in the defect site after 4 weeks of healing. Moreover, the amount of new bone formation in the grafted site is comparable to that reported for other BCP materials and xenografts used in sinus augmentation [14, 29].…”

Section: Discussionsupporting

confidence: 87%

Ridge preservation using an in situ hardening biphasic calcium phosphate (β-TCP/HA) bone graft substitute—a clinical, radiological, and histological study

et al. 2017

View full text Add to dashboard Cite

BackgroundPost-Extraction ridge preservation using bone graft substitutes is a conservative technique to maintain the width of the alveolar ridge. The objective of the present study was to evaluate an in situ hardening biphasic (HA/β-TCP) bone graft substitutes for ridge preservation without primary wound closure or a dental membrane.MethodsA total of 15 patients reported for tooth extraction were enrolled in this study. Implants were placed in average 5.2 ± 2 months after socket grafting. At this visit, Cone Beam CT (CBCT) images and core biopsies were taken. Implant stability (ISQ) was assessed at the insertion as well as at the day of final restoration.ResultsCBCT data revealed 0.79 ± 0.73 mm ridge width reduction from grafting to implant placement. Histomorphometric analysis of core biopsy samples revealed in average 21.34 ± 9.14% of new bone in the grafted sites. Primary implant stability was high (ISQ levels 70.3 ± 9.6) and further increased until final restoration.ConclusionsThe results of this study show that grafting of intact post-extraction sockets using a biphasic in situ hardening bone graft substitute results in an effective preservation of the ridge contour and sufficient new bone formation in the grafted sites, which is imperative for successful implant placement.

show abstract

Section: Discussionsupporting

confidence: 87%

Ridge preservation using an in situ hardening biphasic calcium phosphate (β-TCP/HA) bone graft substitute—a clinical, radiological, and histological study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A CSD is defined as the smallest defect that would not heal spontaneously without intervention for a certain period of healing [14], or which results in less than 10% bone healing during the remaining life span of the experimental animal [15]. The size of CSDs in the rabbit is reportedly up to 17 mm×17 mm [16]; however, many studies have adopted circular 8-, 6-, and even 5-mm defects [2,7,17,18]. Circular 8-mm diameter defects were chosen for the present study.…”

Section: Discussionmentioning

confidence: 99%

Paracrine effect of the bone morphogeneticprotein-2 at the experimental site on healing of the adjacent control site: a study in the rabbit calvarial defect model

Lee

Lim

Lee

et al. 2014

J Periodontal Implant Sci

View full text Add to dashboard Cite

PurposeThe aim of this study was to assess the possible paracrine effect of bone morphogeneticprotein-2 (BMP-2) at the experimental site on the adjacent control site for validating a rabbit calvarial defect model as a means of verifying the effect of BMP-2.MethodsSixteen rabbits were divided into two groups (n=8 in each) according to whether or not BMP-2 would be used. Two circular defects (8 mm in diameter) were created side by side, 2 mm apart, in the calvarium of all of the rabbits. In each animal, one of the defects was grafted with either BMP-2-loaded carrier or carrier material alone. The control defects adjacent to these grafted defects, designated CB (the nongrafted defect adjacent BMP-2-loaded carrier-grafted defect) and CC (the nongrafted defect adjacent to carrier only-grafted defect), respectively, were the focus of this study, and were filled only with a blood clot in all of the animals. Histologic observation and histomorphometric analysis were performed at 2 and 8 weeks (n=4 animals per point in time) after surgery.ResultsThere was no noteworthy difference in the healing pattern, and no statistically significant differences in histomorphometric parameters such as the defect closure, new bone area, or total augmented area between the CC and CB groups.ConclusionsThe results of this study suggest that rabbit calvarial defects separated by a distance of 2 mm are suitable for evaluating the effects of BMP-2 and the control defect can be regarded not to be affected by BMP-2 applied defect.Graphical Abstract

show abstract

“…The cranium of each animal was shaved and disinfected with povidone-iodine, and the surgical site was injected with 1 mL of 2% lidocaine HCL and 1:100,000 epinephrine (Yu-Han Co., Gunpo, Korea). An about 30 mm incision was made on the skull to expose the parietal bones, and four 6-mm-diameter calvarial defects were produced on each rabbit using a dental-trephine bur as described previously [34,35,36]. The same amounts (0.03 ± 0.002 g) of BCP (Bio-C, Cowellmedi, Pusan, Korea), BCP/CMC, BCP/c-CMC, and BCP/HyA were randomly placed on each calvarial defect (Figure 2).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

et al. 2017

View full text Add to dashboard Cite

In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm3) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed.

show abstract

Evaluation of moldable, in situ hardening calcium phosphate bone graft substitutes

Abstract: The moldable, synthetic calcium phosphates are safe and suitable bone graft substitutes with outcomes that are comparable to the control material.

Cited by 55 publications

References 34 publications

Ridge preservation using an in situ hardening biphasic calcium phosphate (β-TCP/HA) bone graft substitute—a clinical, radiological, and histological study

Ridge preservation using an in situ hardening biphasic calcium phosphate (β-TCP/HA) bone graft substitute—a clinical, radiological, and histological study

Paracrine effect of the bone morphogeneticprotein-2 at the experimental site on healing of the adjacent control site: a study in the rabbit calvarial defect model

The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

Contact Info

Product

Resources

About