The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

Yoo, Hyun-Sang; Bae, Jong Hyang; Kim, Se-Eun; Bae, Eun‐Bin; Kim, So-Yeun; Choi, Kwanghoon; Moon, Keumok; Jeong, Chang-Mo; Huh, Jung-Bo

doi:10.3390/ma10010017

Cited by 21 publications

(18 citation statements)

References 41 publications

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“…The tunnel β‐TCP block exhibited a greater volume of new bone formation and horizontal width at the coronal site. Hardened bone grafts such as block‐type grafts have a greater potential for bone regeneration than particulate bone grafts . β‐TCP/PLGA is easily moldable and hardens rapidly.…”

Section: Discussionmentioning

confidence: 99%

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

Okada

Matsuura

Akizuki

et al. 2019

Journal of Periodontology

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Background:The alveolar ridge undergoes pronounced reduction in height and width following tooth extraction. This study aims to comparatively evaluate the potential for ridge preservation in extraction sockets with buccal bone deficiency of -tricalcium phosphate coated with poly lactide-co-glycolide ( -TCP/PLGA) and conventional particulate -TCP. Methods:In six beagles, maxillary first premolars were extracted after removal of their buccal bone plates. Standardized bone defects (4 [mesiodistal width] × 4 [buccopalatal width] × 5 [depth] mm) were created at the sites of extraction sockets and filled with -TCP/PLGA (test sites) or particulate -TCP (control sites). Microcomputed tomography, histologic, and histometric evaluations were performed 12 weeks post-surgery. Results:The test sites exhibited a significantly greater bone volume than the control sites (25.7 ± 2.14 versus 16.0 ± 3.3 mm 3 ), although no statistically significant difference was detected in bone material density (746.3 ± 23.9 versus 714.5 ± 37.0 g/cm 3 , respectively). Relative to the control sites, the test sites exhibited significantly greater alveolar-ridge coronal (2.0 ± 0.4 versus 1.1 ± 0.3 mm) and middle (2.9 ± 0.2 versus 2.1 ± 0.3 mm) horizontal widths and proportions of woven bone (50.3 ± 8.1% versus 38.0 ± 5.2%) and bone marrow (17.7 ± 6.6% versus 9.7 ± 4.1%) but a significantly lower proportion of connective tissue (10.7 ± 4.5% versus 18.3 ± 5.7%). Conclusion:Within the limitations of this study, the moldable -TCP/PLGA graft appears to exhibit a greater potential than the conventional particulate -TCP graft for ridge preservation of extraction sockets with buccal bone deficiency. K E Y W O R D Salveolar ridge augmentation, -tricalcium phosphate, biocompatible materials, dogs, osteogenesis, tooth extraction 1014

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Section: Discussionmentioning

confidence: 99%

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

Okada

Matsuura

Akizuki

et al. 2019

Journal of Periodontology

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“…To evaluate the formation of new bone, the cross-sectional area of new bone, residual graft material and connective tissue within 8 mm defect was measured, respectively. Then, the calculation formula from previous literatures (new bone area percent (%) = new bone area (mm 2 )/(new bone area (mm 2 ) + residual graft materials (mm 2 ) + connective tissue (mm 2 )) was used to perform comparative evaluation on bone formation ( Figure 3 ) [ 21 , 22 , 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

et al. 2020

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Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

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“…Amphoteric metal oxide, such as Al 2 O 3 ,112,194,200 ZnO,169 and ZrO 2 ,125,193 can react with HF in the electrolytes and act a role of scavenger, so the dissolution process of transition metal (Ni, Co, and Mn) from electrode surface to electrolytes can be relieved. Han et al201 studied the role of Al 2 O 3 with lower coating content and thinner coating on the surface of NCM‐523 prepared by different annealing temperature (Figure 10c).…”

Section: Service Life Of Ni‐rich Ncm For Libsmentioning

confidence: 99%

Ni‐Rich/Co‐Poor Layered Cathode for Automotive Li‐Ion Batteries: Promises and Challenges

Wang

Ding

Deng

et al. 2020

Advanced Energy Materials

299

218

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To pursue a higher energy density (>300 Wh kg−1 at the cell level) and a lower cost (<$125 kWh−1 expected at 2022) of Li‐ion batteries for making electric vehicles (EVs) long range and cost‐competitive with internal combustion engine vehicles, developing Ni‐rich/Co‐poor layered cathode (LiNi1−x−yCoxMnyO2, x+y ≤ 0.2) is currently one of the most promising strategies because high Ni content is beneficial to high capacity (>200 mAh g−1) while low Co content is favorable to minimize battery cost. Unfortunately, Ni‐rich cathodes suffer from limited structure stability and electrode/electrolyte interface stability in the charged state, leading to electrode degradation and poor cycling performance. To address these problems, various strategies have been employed such as doping, structural optimization design (e.g., core–shell structure, concentration‐gradient structure, etc.), and surface coating. In this review, five key aspects of Ni‐rich/Co‐poor layered cathode materials are explored: energy density, fast charge capability, service life including cycling life and calendar life, cost and element resources, and safety. This enables a comprehensive analysis of current research advances and challenges from the perspective of both academy and industry to help facilitate practical applications for EVs in the future.

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The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

Cited by 21 publications

References 41 publications

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Ni‐Rich/Co‐Poor Layered Cathode for Automotive Li‐Ion Batteries: Promises and Challenges

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