Evaluation of MRI criteria (1.5T) for the diagnosis of hippocampal sclerosis in healthy subjects

Crossed aphasia after right anterior temporal lobectomy. A case report

“…Slightly decreased volume of the left hippocampus that did not meet the criteria for HS was also observed [18] ( Fig. 1).…”

“…to have left language dominance based on strong right-handedness, no family history of left-handedness, and no presurgical difficulties in more than one language skill (reading, naming, comprehension, repetition, and speech) [28]. Although it is possible that MRI findings justify the presurgical cognitive profile (verbal and nonverbal cognitive impairment), like the slightly decreased volume in the left hippocampus that did not meet the criteria of HS [18], we did not give relevance to this finding. In our experience, approximately 18% of the population with an epileptogenic zone in the non-dominant hemisphere and memory impairment [5] showed a deficit in both memories.…”

Morphological imaging of the hippocampus in epilepsy

“…6). However, a unilateral enlarged temporal horn, with a similar aspect to the one observed in hippocampal sclerosis, also occurs frequently in healthy subjects, so that MRI evidences for HS are meaningful only in the proper clinical context and should not be considered pathologic in isolation [36].…”

Presurgical Assessment of Patients with Refractory Temporal Lobe Epilepsy

“…Furthermore, it is important to note that incidental hippocampal sclerosis, an entity recognized in the field of neuroimaging and debated in the epilepsy groups, requires special mention. From the histopathological point of view there are reports of HS in up to 10% of individuals without epilepsy (Menzler, 2010). This incidental MRI finding in patients without epilepsy is rare and requires the strict clinical correlation discarding undocumented seizure syndrome (Kevin, 1999).…”