Evaluation of Multi Frequency Repeaters for Record of Cardiovascular Parameters in Group Housed Dogs

Francine, El Amrani; Martel, Eric; Champéroux, Pascal; Richard, Serge; Rieux, Eric; Singer, Dan

doi:10.1016/j.vascn.2007.02.043

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, investigators have devised effective solutions to this problem, including the use of multiple discrete frequencies 19 or repeater collars with discrete frequencies. 21 Recent technological advances have occurred in noninvasive and minimally invasive blood pressure measurement systems often used in repeat-dose toxicology studies. These technologies are discussed later in this article.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Function in Nonclinical Drug Safety Assessment

et al. 2011

View full text Add to dashboard Cite

There are several recent examples where clinically significant, safety-related, drug effects on hemodynamics or cardiac function were not apparent until large clinical trials were completed or the drugs entered the consumer market. Such late-stage safety issues can have significant impact on patient health and consumer confidence, as well as ramifications for the regulatory, pharmaceutical, and financial communities. This manuscript provides recommendations that evolved from a 2009 HESI workshop on the need for improved translation of nonclinical cardiovascular effects to the clinical arena. The authors conclude that expanded and improved efforts to perform sensitive yet specific evaluations of functional cardiovascular parameters in nonclinical studies will allow pharmaceutical companies to identify suspect drugs early in the discovery and development process while allowing promising drugs to proceed into clinical development.

show abstract

Section: Discussionmentioning

confidence: 99%