Evaluation of Muscle Cramp Associated with Liver Cirrhosis with a Focus on the Liver Function and Nutritional Status

Shimada, Muneaki; Hirashima, Noboru; Iwase, Hiroaki; Saito, Masashi; Kondo, Hisashi; Urata, Noboru; Unita, Satoshi; Kondo, Takashi; Tanaka, Daiki; Tsunekawa, Takuya; Fujishiro, Mitsuhiro

doi:10.2169/internalmedicine.6231-20

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…In addition, we previously reported that a high percentage (51.8%) of patients with CLD with sleep disorders experienced muscle cramps [6]. Moreover, a decrease in muscle mass is likely to result in the onset of muscle cramps [31]. Thus, sleep disturbance may be associated with liver-related complications.…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of the Athens Insomnia Scale for Evaluating Sleep Disturbance in Patients with Chronic Liver Disease Comparing with Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale

et al. 2022

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Background and Objectives: Sleep disturbance due to muscle cramps or hepatic encephalopathy in patients with chronic liver disease (CLD) can lead to a reduced quality of life. The Pittsburgh sleep quality index (PSQI) is commonly used for evaluating sleep disturbance; however, this questionnaire is time-consuming owing to the large number of questions. As the usefulness of the Athens insomnia scale (AIS) in patients with CLD is not sufficiently known, the present study aimed to determine whether the AIS and Epworth sleepiness scale (ESS) could be used as simple alternative questionnaires for evaluating sleep disturbances in patients with CLD. Materials and Methods: A total of 117 patients with CLD were retrospectively evaluated. Patients with overt hepatic encephalopathy were excluded. All patients were examined using the AIS, PSQI, and ESS, and their responses to these questionnaires were statistically analyzed. Results: The number of patients diagnosed with sleep disturbance using the AIS, PSQI, and ESS were 39 (33.3%), 37 (31.6%), and 9 (7.7%), respectively. There was no correlation between PSQI and ESS scores (r = 0.011, p = 0.910); in contrast, the AIS scores showed a significant correlation with the PSQI scores (r = 0.689, p < 0.001). When the PSQI was considered as the standard for evaluating sleep disturbance, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the AIS were 76.9%, 91.0%, 81.1%, and 88.8%, respectively. In the sleep medication group, the sensitivity, specificity, PPV, and NPV of the AIS were 100%, 70%, 78.6%, and 100%, respectively. Conclusions: This is the first report to indicate that the AIS is an alternative questionnaire to the PSQI and that it can be a useful tool for detecting cirrhosis-related complications in patients with CLD.

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Section: Discussionmentioning

confidence: 99%

The Usefulness of the Athens Insomnia Scale for Evaluating Sleep Disturbance in Patients with Chronic Liver Disease Comparing with Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale

et al. 2022

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“…uptake of contrast materials by the liver) on contrast-enhanced CT or MRI, are reportedly J o u r n a l P r e -p r o o f influenced by liver function as measured by ALBI [94][95][96]. Other studies have reported the effect of liver function, as assessed by ALBI, on serum levels of tumor markers such as, CA-125 [97] and the frequency of muscle cramps in cirrhotic patients [98]. Several pharmacokinetic studies have assessed the role of liver dysfunction in relation to drug-induced adversity [99][100][101].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“… [94] , [95] , [96] Other studies have reported the effect of liver function, as assessed by ALBI, on serum levels of tumour markers, such as CA-125, 97 and the frequency of muscle cramps in patients with cirrhosis. 98 Several pharmacokinetic studies have assessed the role of liver dysfunction in relation to drug-induced adverse events. [99] , [100] , [101] …”

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 99%

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Evaluation of Muscle Cramp Associated with Liver Cirrhosis with a Focus on the Liver Function and Nutritional Status

Cited by 2 publications

References 25 publications

The Usefulness of the Athens Insomnia Scale for Evaluating Sleep Disturbance in Patients with Chronic Liver Disease Comparing with Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale

The Usefulness of the Athens Insomnia Scale for Evaluating Sleep Disturbance in Patients with Chronic Liver Disease Comparing with Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale

The ALBI score: From liver function in patients with HCC to a general measure of liver function

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