Evaluation of myocardial deformation pattern of left ventricular noncompaction by cardiac magnetic resonance tissue tracking

Pu, Cailing; Hu, Xiuhua; Yang, Ya Ling; Lv, Sangying; Fei, Jing-Le; Albaqali, Samar Mohamed; Hu, Hongjie

doi:10.33963/kp.15133

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Regarding the LVNC patients with good LV function, their GLS was not different from that of the control group, which is in accordance with the results of Gastl et al [29]. However, this may be controversial, as other researchers found impaired GLS in both adult and pediatric LVNC patient populations despite having good LV function [22,30]. These conflicting results could be due to the non-linear relationship between LV ejection fraction and GLS, namely, there is a stronger correlation between these two parameters at lower EF, and the curve flattens when the EF is higher than 50%.…”

Section: Discussionsupporting

confidence: 86%

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Szũcs¹,

Kiss²,

Gregor³

et al. 2021

International Journal of Cardiology

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Background: There is a lack of cardiac MRI information on left ventricular (LV) strain and rotational parameters of left ventricular noncompaction (LVNC) patients with reduced ejection fraction (EF). Thus, we sought to use feature tracking (FT) to describe these changes at different levels of EF deterioration. Methods: We included 31 adult LVNC patients with reduced LV EF (Group B, EF < 50%) without any comorbidities or concomitant cardiac diseases, 31 age-and sex-matched LVNC patients with good EF (Group A, EF > 50%) and 31 healthy controls. Group B was divided according to LV EF into two subgroups (Group B-1: EF 35-50%, Group B-2: EF < 35%). Their global longitudinal, circumferential (GCS), and radial (GRS) strains; LV segmental strains; LV apical and basal rotation values; and patterns and degree of LV dyssynchrony were measured. Results: All of the global and mean segmental strain parameters were significantly worse in Groups B, B-1 and B-2 than in Group A and in the controls. The LV mechanical dispersion increased as LV EF decreased. The degree of apical rotation was the highest in the control group, almost the same in Group A and the lowest and in the reverse direction in Group B-2. A rotational pattern, clockwise-directed rigid body rotation (RBR), was found in 39% of the Group B patients, and a counterclockwise-directed RBR was found in 26% of the Group A patients. Conclusions: The strain values and rotational parameters changed as the EF decreased. These changes affected the global LV, and we did not identify an LVNC-specific strain pattern.

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Section: Discussionsupporting

confidence: 86%

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Szũcs¹,

Kiss²,

Gregor³

et al. 2021

International Journal of Cardiology

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“…Interestingly, LV GLS is not consistently found to be impaired in LVNC patients with preserved LV systolic function. Pu et al showed significant differences in this parameter between the patients and the controls, comparably to the observations made by Nucifora et al and the results of our study, in which 15/16 had preserved LV EF [20,38]. Simultaneously, Sz űcs et al and Gastl et al did not observe differences in LV GLS between LVNC patients with LV EF >50% and controls, and in the study by Dreisbach et al there were no significant differences between adults with LVNC and normal LV volumes and the controls [28,36,37].…”

Section: Morphology and Functionsupporting

confidence: 92%

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Sarnecki

Paszkowska

Petryka-Mazurkiewicz

et al. 2022

JCM

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Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. Methods: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. Results: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all p < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both p < 0.05). Conclusions: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation.

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“…Isolated left ventricular myocardial noncompaction (ILVNC) is a rare cardiomyopathy characterized by a massive trabecular protrusion under the left ventricular (LV) endocardium, with the trabeculae connected to the LV lumen, and no other cardiac congenital malformations (1). Dilated cardiomyopathy (DCM) is a type of cardiomyopathy characterized by LV enlargement with systolic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Value of cardiac magnetic resonance feature tracking technology in the differential diagnosis of isolated left ventricular noncompaction and dilated cardiomyopathy

Zhu¹,

Wu²,

Hao³

et al. 2023

Quant Imaging Med Surg

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Background: This study explored the value of myocardial strain in the differential diagnosis of isolated left ventricular myocardial noncompaction (ILVNC) and dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) feature tracking technology. Methods: This retrospective analysis was performed on consecutive patients (25 with ILVNC, 30 with DCM, and 30 healthy controls) presenting to Shanxi Cardiovascular Hospital. All ILVNC patients met echocardiographic and CMR criteria for ventricular non-compaction. All patients with DCM met the 2016 American Heart Association and 2018 Chinese Medical Association Cardiovascular Branch diagnostic criteria. cvi42 software (Circle Cardiovascular Imaging) was used to measure radial, circumferential, and longitudinal strain (LS) globally and in segments of the left ventricle. Analysis of variance was used to compare strains among groups and among different segments within the same group. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of different parameters in ILVNC and DCM.Results: Basal circumferential strain was lower in the DCM than in the ILVNC group (P=0.05). Both median and apical LS were lower in the ILVNC than in DCM group (P=0.02 and P=0.01, respectively).ROC curves showed that apical LS was the most effective in distinguishing ILVNC from DCM [area under the curve (AUC) 0.883; P<0.001; 95% CI: 0.850-0.977]. Comparing strains among different segments within the same group revealed that in DCM, the circumferential and LS of the apex were higher than those of the basal segment, which is consistent with the pattern in healthy controls; however, has no such regular pattern was seen in ILVNC.Conclusions: Myocardial strain parameters are of considerable value in the differential diagnosis of ILVNC and DCM. Differences in patterns between ILVNC and DCM can be sensitively identified, providing more comprehensive information for early clinical diagnosis.

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Evaluation of myocardial deformation pattern of left ventricular noncompaction by cardiac magnetic resonance tissue tracking

Cited by 4 publications

References 4 publications

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Value of cardiac magnetic resonance feature tracking technology in the differential diagnosis of isolated left ventricular noncompaction and dilated cardiomyopathy

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