Evaluation of Myocardial State by Synchronized Radiography and Exercise

Phillips, William J.; Higginbotham, Hugh B.; Frerking, H; Paine, R.M.

doi:10.1056/nejm196604142741504

Cited by 9 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In both conditions, a deficit in cardiac catecholamines and an increase in plasma and urinary catecholamines have been reported. [54][55][56] Direct measurements of right ventricular fiber shortening were performed following nitroglycerin and propranolol. This was made possible by a newly developed strain gauge assembly.…”

Section: Oxidation-reduction Potential Of Heart Musclementioning

confidence: 99%

A Comparative Study of Nitroglycerin and Propranolol

et al. 1967

View full text Add to dashboard Cite

The action of sublingual nitroglycerin (0.6 mg) and intravenous propranolol (0.1 mg/kg) on shortening of right ventricular fibers was investigated in patients with and without coronary artery disease. This was accomplished with a newly devised strain gauge catheter. Hemodynamic parameters and changes in the oxidation-reduction potential of heart muscle were determined. Nitroglycerin results in decrease in shortening and velocity of shortening of ventricular fibers, heart rate, left ventricular end-diastolic and systemic pressure, dp/dt, tension-time index, stroke index, peripheral resistance, and left ventricular minute work in normal and arteriosclerotic subjects. Intravenous propranolol leads to a fall in velocity of shortening of myocardial fibers, heart rate, dp/dt, stroke index, and left ventricular minute work. However, there is an increase in tension-time index and peripheral resistance with no change in systemic pressure. Left ventricular end-diastolic pressure rises significantly in arteriosclerotic patients. The myocardial oxidation-reduction potential increases after nitroglycerin whereas it falls after propranolol in normal and arteriosclerotic patients. Additional Indexing Words: HemodynamicsVelocity of fiber shorte:Lactic-pyruvic acid ratio

show abstract

Section: Oxidation-reduction Potential Of Heart Musclementioning

confidence: 99%