The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The action of sublingual nitroglycerin (0.6 mg) and intravenous propranolol (0.1 mg/kg) on shortening of right ventricular fibers was investigated in patients with and without coronary artery disease. This was accomplished with a newly devised strain gauge catheter. Hemodynamic parameters and changes in the oxidation-reduction potential of heart muscle were determined. Nitroglycerin results in decrease in shortening and velocity of shortening of ventricular fibers, heart rate, left ventricular end-diastolic and systemic pressure, dp/dt, tension-time index, stroke index, peripheral resistance, and left ventricular minute work in normal and arteriosclerotic subjects. Intravenous propranolol leads to a fall in velocity of shortening of myocardial fibers, heart rate, dp/dt, stroke index, and left ventricular minute work. However, there is an increase in tension-time index and peripheral resistance with no change in systemic pressure. Left ventricular end-diastolic pressure rises significantly in arteriosclerotic patients. The myocardial oxidation-reduction potential increases after nitroglycerin whereas it falls after propranolol in normal and arteriosclerotic patients. Additional Indexing Words: HemodynamicsVelocity of fiber shorte:Lactic-pyruvic acid ratio

The activity of γ-glutamyl-transpeptidase was determined serially in patients with acute myocardial infarction up to 32 days after the onset of chest pain. Peak enzyme activity was found in all patients between the eighth and eleventh day after infarction. Some patients showed a rise in serum activity 48 hr after infarction. In 33 mongrel dogs with experimental myocardial infarction, γ-glutamyl-transpeptidase activity was estimated in the homogenate of the normal and necrotic heart muscle as soluble and particle-bound enzyme activity. The changes of free and particle-bound activity showed different patterns. The soluble enzyme activity was highest during the first 4 days and approached normal level after 8 days. Particle-bound activity was significantly decreased after 24 hr and showed thereafter a continuous rise to 10 times the control values 10 days after the coronary artery occlusion. These studies indicate that several determinations of γ-glutamyl-transpeptidase activity in serum of patients with myocardial infarction may reflect the reparative processes taking place in the infarcted tissue.

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