The effects of nitroglycerin on myocardial blood flow in man

Cowan, Charles; Duran, Pedro V. M.; Corsini, G; Goldschlager, Nora; Bing, Richard J.

doi:10.1016/0002-9149(69)90397-x

Cited by 54 publications

(5 citation statements)

References 25 publications

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“…Normal AIBF values reported by other investigators using the 84Rb method (13)(14)(15)18) are some 35% lower than ours. We suspect a methodological basis for this difference: the increased resolution of our instrumentation as well as advantages conferred by improved mechanical design, as discussed in Methods, would be expected to yield higher net myocardial counts.…”

Section: Detailed Findings Are Presented Incontrasting

confidence: 77%

“…These have the advantage of measuring absolute rather than unit flow, but nevertheless, only a fraction of the entire coronary flow is involved. If one accepts the normal values for man which have been published to date then coronary sinus flow (12) is not greater than approximately 50% of myocardial blood flow (13)(14)(15).…”

mentioning

confidence: 99%

“…Since the entire organ uptake of isotope is measured, all zones are represented according to their degree of perfusion. Bing et al have developed this technique for measurement of "nutrient" or "effective" myocardial blood flow (MBF)' (17) and values for normal subjects and patients with coronary disease have been reported by them and by other investigators (13)(14)(15)18).…”

mentioning

confidence: 99%

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Total and effective coronary blood flow in coronary and noncoronary heart disease.

Mymin¹,

Sharma²

1974

J. Clin. Invest.

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A B S T R A C T There are no data available concerning total coronary blood flow to the whole heart (CBF) in man. "Effective" or "nutrient" coronary blood flow to the whole heart (MBF), supposedly a measure of flow through exchanging channels of the coronary circulation, has been measured but its validity has not been established. Accordingly, CBF and MBF were measured in 9 normal subjects, 26 patients with coronary heart disease (CHD), and 19 with noncoronary, mostly valvular heart disease (NCHD), by coincidence counting 'Rb technique. Two methods were used: single bolus (24 cases) and continuous infusion (30 cases). Various other parameters including myocardial oxygen utilization (MVO2) and lactate extraction ratio were determined.In the normal subjects CBF (386±77 ml/min) was significantly higher (P < 0.05) than in CHD (288±+124 ml/min) and NCHD (292±111 ml/min). Likewise the normal MBF (380±81 ml/min) was significantly higher (P < 0.01) than in CHD (251±105 ml/min) as well as NCHD (258±+104 ml/min). The myocardial Rb extraction ratio (ERb) was significantly lower in normal subjects (39±9%) than in CHD (50±7%) and NCHD

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Section: Detailed Findings Are Presented Incontrasting

confidence: 77%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Total and effective coronary blood flow in coronary and noncoronary heart disease.

Mymin¹,

Sharma²

1974

J. Clin. Invest.

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“…Cowan et al [6] coincidence counting 179 (total heart) Luebs et al [14] coincidence counting 242 (total heart) a mean CS flow of 128 and 134 ml/min in patients with angiographically confirmed coronary artery disease. In subjects with normal hearts, the CS flow was 122 and the GCV flow 68 ml/min, values quite similar to those reported [1,15] in patients with and without angina pectoris.…”

Section: Discussionmentioning

confidence: 99%

Aspects of Cardiac Venous Flow Measured by the Continuous Infusion Thermodilution Technique

Simonsen¹

1977

Cardiology

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The continuous infusion thermodilution method for the measurement of cardiac venous blood flow was investigated in 26 patients with angina pectoris. In 10 patients, the correlation coefficients for duplicate flow measurements within 1 min were 0.98 for the coronary sinus (CS) and 0.99 for the great cardiac vein (GCV), with a variation in relation to mean flow of 3.3 and 3.5%, respectively. The average CS drainage in 16 patients amounted to 126 ml/min with the GCV contributing 57% of the total and all other veins (OV) draining into the sinus 43%. Sub-maximal atrial pacing led to a significant increase in flow in all veins. The mean increase in flow per heart beat was 1.41 ml in the CS, 0.93 ml in the GCV, and 0.58 ml in the OV. The increase in flow per unit (1 × 10^-3 mm Hg . beats) heart rate times blood pressure product was 9.18, 6.97 and 4.71 ml, respectively. The method is suitable for the measurement of rapid changes in total and regional left ventricular blood flow under different conditions. For longer studies spontaneous changes in parameters governing myocardial oxygen demand must be taken into consideration.

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“…Nitroglycerin, however, is not so excellent in this regard, and in addition, nitroglycerin does not dilate the coronary vessels in patients with coronary sclerosis and angina pectoris (24). Cowan et al (25) observed that nitroglycerin administered sub lingually increased myocardial blood flow in both normal subjects and patients with co ronary heart disease. However, this increase in myocardial blood flow was observed to take place only during the early post-administrative stage.…”

Section: Discussionmentioning

confidence: 99%

Redox State of Nicotinamide-Adenine Dinucleotide in the Inner and Outer Layers of Canine Left Ventricle, and Effects of Coronary Dilators on the Redox State

Hayashi

Takano

Hashikawa

et al. 1974

Japanese Journal of Pharmacology

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The effects of nitroglycerin on myocardial blood flow in man

Cited by 54 publications

References 25 publications

Total and effective coronary blood flow in coronary and noncoronary heart disease.

Total and effective coronary blood flow in coronary and noncoronary heart disease.

Aspects of Cardiac Venous Flow Measured by the Continuous Infusion Thermodilution Technique

Redox State of Nicotinamide-Adenine Dinucleotide in the Inner and Outer Layers of Canine Left Ventricle, and Effects of Coronary Dilators on the Redox State

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