Evaluation of nano-magnetic fluid on malignant glioma cells

Abstract

The temperature variation rule of nano-magnetic fluid in the specific magnetic field and the effect on the treatment of malignant glioma were examined. The temperature variation of nano-magnetic fluid in the specific magnetic field was investigated by heating in vitro, and cell morphology was observed through optical microscopy and electron microscopy. MTT detection also was used to detect the effect of Fe3O4 nanometer magnetic fluid hyperthermia (MFH) on the proliferation of human U251 glioma cell line. The Fe3O4 nano MFH experiment was used to detect the inhibition rate of the tumor volume in nude mice with tumors. The results of the experiment showed that the heating ability of magnetic fluid was positively correlated with its concentration at the same intensity of the magnetic field. The results also indicated the prominent inhibitory effect of nanometer MFH on the proliferation of glioma cells, which was a dose-dependent relationship with nanometer magnetic fluid concentration. The hyperthermia experiment of nude mice with tumors displayed a significant inhibiting effect of Fe3O4 nanometer magnetic fluid in glioma volume. These results explain that iron (II, III) oxide (Fe3O4) nanometer MFH can inhibit the proliferation of U251 glioma cells, and has an obvious inhibitory effect on glioma volume, which plays a certain role in the treatment of brain glioma.

WITHDRAWN: Effect of DMSO@γ-Fe2O3 nanomagnetic fluid thermotherapy combined with docetaxel on the biological behavior of human gastric cancer AGS cells under the alternating magnetic field

“…Literature shows [4] that the ability of tumor cells to absorb magnetic nanoparticles is 8 ~ 400 times that of normal cells. After research, nanomagnetic uid thermotherapy has made good progress in the study of glioma [5], esophageal cancer [6], lung cancer [7][8][9], hepatocellular carcinoma [10][11], pancreatic cancer [12][13][14] and breast cancer [15][16][17] cancers, which have not been reported in the treatment of gastric cancer. In this study, we used in vitro cultured gastric cancer cell AGS to investigate the effect of DMSO@γ-Fe 2 O 3 nanomagnetic uid thermotherapy combined with docetaxel on the biological behavior of human gastric cancer cell AGS under alternating magnetic eld, which provides experimental basis for the role of nanomagnetic uid thermotherapy combined with chemotherapy in gastric cancer treatment.…”

Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans

“…The surface temperature of the gel was monitored using an infra-red camera. A third group demonstrated the apoptotic and necrotic effects of MHT in vitro on U251 glioma cells [99]. Iron oxide MNPs were utilised for MHT application and a digital thermometer was used every 5-min for temperature recording.…”

“…In a more recent in vivo MHT study, U251 human glioma cells were implanted into the right lower limb of rats [99]. Rats in the control group did not receive MNPs or MHT.…”

Preparation of Hematoporphyrin-Poly(Lactic Acid) Nanoparticles Encapsulated Perfluoropentane/Salicylic Acid for Enhanced US/CEST MR Bimodal Imaging

“…However, tumor removal poses numerous challenges due to its aggressive nature, rapid growth, high heterogeneity, and indistinguishable boundaries from healthy tissue. 1 These complexities underscore the need for advanced real-time diagnosis and therapeutic techniques that can precisely define tumor boundaries, guide surgical resections, and detect any residual tumor cells. 2,3 In recent decades, medical imaging technology has undergone remarkable advancements, with multimodality imaging emerging as a particularly valuable tool in the early diagnosis, treatment monitoring, and prognosis of various diseases.…”