Evaluation of neonatal jaundice in the Makkah region

Abstract

The aims of this study were to detect the frequency at which the different types of neonatal jaundice occur in Makkah and to estimate the malondialdehyde (MDA) levels. This study included 239 neonates with neonatal jaundice, 20 anemic neonates and 21 healthy neonates. ABO incompatibility was observed in 31.6% of neonates with indirect hyperbilirubinemia, in 14.3% of those with early onset jaundice, in 9.5% of those with persistent jaundice, in 8.5% of those with physiological jaundice, in 5% of anemic neonates and in 12% of all neonates. glucose-6-phosphate dehydrogenase (G6PD) deficiency was observed in 10.5% of neonates with indirect hyperbilirubinemia, in 3.9% of those with physiological jaundice, in 11.1% of those with direct hyperbilirubinemia, in 12% of those with persistent jaundice, in 10% of anemic neonates and in 6.6% of all neonates. Rh incompatibility and polycythemia were found in 2.6% of neonates with indirect hyperbilirubinemia and in 0.4% of all neonates. In comparison to control group, MDA was significantly higher in all groups except for the anemic group. In conclusion, ABO incompatibility and G6PD deficiency frequently result in neonatal jaundice in Makkah, whereas Rh incompatibility and polycythemia are rare. The MDA level may serve as an indicator of oxidative stress.

Ictères pathologiques du nouveau-né à l’hôpital Bonzola de Mbuji-Mayi, République Démocratique du Congo

“…Barkat trouve dans sa série que les étiologies des ictères néonataux pathologiques étaient dominées par les infections suivies des incompatibilités materno-fœtales [ 18 ]. Dans d'autres séries, c'est l'incompatibilité foeto-maternelle ABO qui vient en tête [ 4 , 25 ]. Les travaux réalisés aux Cliniques Universitaires de Kinshasa par Tady donnent l'incidence de chaque étiologie de la manière suivante: incompatibilité fœto-maternelle dans 42% (dont 37% ABO), infections dans 23%, immaturité dans 6%, enzymopathie (déficit en G6PD) dans 5% et obstruction des voies biliaires dans 4% [ 20 ].…”

“…Les incompatibilités rhésus sont rares dans notre série et cette rareté serait due à celle du rhésus négatif dans notre milieu comme l'avaient confirmé déjà les travaux de Resseler en 1962 [ 26 ]. Cette faible incidence de l'incompatibilité Rhésus est aussi constatée dans l’étude de Alkhotani menée dans la région de Makkah qui rapporte que l'incompatibilité ABO et le déficit en G6PDsont les causes fréquentes de l'ictère néonatal alors que l'incompatibilité rhésus et la polyglobulie sont rares dans cette région [ 25 ]. Etant donné que les antibiotiques sont largement utilisés dans le cadre de toute suspicion d'infection néonatale, certaine ou probable (cas de méningite, sepsis ou d'autres infections à pyogènes), nous avons mis à contribution cette attitude dans notre série pour tous les cas dont l’étiologie n’était pas solidement établie ou en cas de suspicion d'infection comme repris au Tableau 3 .…”

Assessment of Knowledge, Attitude and Practice of Saudi Parents towards Neonatal Jaundice (NNJ) : A Cross-Sectional Study

“…Increased incidence of NNJ could also be observed in breastfed neonates receiving suboptimal milk intake resulting in inadequate fluid and nutritional intake (6) . In Saudi Arabia, ABO incompatibility was observed in 31.6% of neonates with indirect hyperbilirubinemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency was observed in 10.5% of neonates with indirect hyperbilirubinemia, Rh incompatibility and polycythemia were found in 2.6% of neonates with indirect hyperbilirubinemia and in 0.4% of all neonates (7) .…”

Safe and Symptomatic Medicinal Use of Surface-Functionalized Mn 3 O 4 Nanoparticles for Hyperbilirubinemia Treatment in Mice

“…Hyperbilirubinemia is caused when there is an imbalance between production of BR (resulting from hemolysis, sepsis, blood extravasation or polycythemia) and decrease in BR excretion due to inadequate hepatic conjugation and increased enterohepatic reabsorption (resulting from pyloric stenosis, delayed bacterial gut colonization, GI tract immobility or obstruction) [1][2][3]. Although at micromolar concentrations BR acts as an antioxidant for scavenging peroxyl radicals in blood [4], yet it can be toxic and harmful to cells at higher concentration [5,6].…”